Associations Between Casein Haplotypes and First Lactation Milk Production Traits in Finnish Ayrshire Cows

Ikonen, Tiina; Bovenhuis, H.; Ojala, Matti; Ruottinen, O.; Georges, Michel

doi:10.3168/jds.s0022-0302(01)74501-8

Cited by 89 publications

(82 citation statements)

References 25 publications

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“…A number of attempts have been made to detect an association between the casein gene complex located on BTA6 and milk production [12,32,40,62]. Bovenhuis and Weller [12] used protein genes as markers to detect the linked QTL in the Dutch dairy cattle.…”

Section: Milk Yieldmentioning

confidence: 99%

Quantitative trait loci mapping in dairy cattle: review and meta-analysis

et al. 2004

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-From an extensive review of public domain information on dairy cattle quantitative trait loci (QTL), we have prepared a draft online QTL map for dairy production traits. Most publications (45 out of 55 reviewed) reported QTL for the major milk production traits (milk, fat and protein yield, and fat and protein concentration (%)) and somatic cell score. Relatively few QTL studies have been reported for more complex traits such as mastitis, fertility and health. The collated QTL map shows some chromosomal regions with a high density of QTL, as well as a substantial number of QTL at single chromosomal locations. To extract the most information from these published records, a meta-analysis was conducted to obtain consensus on QTL location and allelic substitution effect of these QTL. This required modification and development of statistical methodologies. The meta-analysis indicated a number of consensus regions, the most striking being two distinct regions affecting milk yield on chromosome 6 at 49 cM and 87 cM explaining 4.2 and 3.6 percent of the genetic variance of milk yield, respectively. The first of these regions (near marker BM143) affects five separate milk production traits (protein yield, protein percent, fat yield, fat percent, as well as milk yield).quantitative trait loci / dairy cattle / review / meta-analysis

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Section: Milk Yieldmentioning

confidence: 99%

Quantitative trait loci mapping in dairy cattle: review and meta-analysis

et al. 2004

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“…This was first suggested in cattle by Grosclaude et al (1978) and was further developed in the same species (Aleandri et al, 1990;Ikonen et al, 2001;Boettcher et al, 2004;Caroli et al, 2004). The effect of an allele at a given locus could be confounded with the effect of linked alleles at another locus.…”

Section: Introductionmentioning

confidence: 99%

Casein Haplotype Structure in Five Italian Goat Breeds

Sacchi¹,

Chessa

Budelli

et al. 2005

Journal of Dairy Science

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The aim of this work was to investigate the genetic structure of the casein gene cluster in 5 Italian goat breeds and to evaluate the haplotype variability within and among populations. A total of 430 goats from Vallesana, Roccaverano, Jonica, Garganica, and Maltese breeds were genotyped at α s1 -casein (CSN1S1), α s2 -casein, (CSN1S2), β-casein (CSN2), and κ-casein (CSN3) loci using several genomic techniques and milk protein analysis. Casein haplotype frequencies were estimated for each breed. Principal component analysis was carried out to highlight the relationship among breeds. Allele and haplotype distributions indicated considerable differences among breeds. The haplotype CSN1S1*F-CSN1S2*F-CSN3*D occurred in all breeds with frequencies >0.100 and was the most common haplotype in the Southern breeds. A high frequency of CSN1S1*0-CSN1S2*C-CSN3*A haplotype was found in Vallesana population (0.162). Principal component analysis clearly separated the Northern and Southern breeds by the first component. The variability of the caprine casein loci and variety of resulting haplotypes should be exploited in the future using specific breeding programs aiming to preserve biodiversity and to select goat genetic lines for specific protein production. (Key words: goat, casein, polymorphism, haplotype) Abbreviation key: AS-PCR = allele specific-PCR, CSN1S1 = α s1 -casein locus, CSN1S2 = α s2 -casein locus, CSN3 = κ-casein locus, CSN2 = β-casein locus, IEF = isoelectrofocusing, PCR-SSCP = PCR-single strand conformational polymorphism.

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“…The genes are organised in a cluster of approximately 250 kB [13,41] and share common transcription regulating elements [41]. The locus is considered to influence milk production traits [8,9,17,22,46] and antibacterial activities of derived peptides [29] may also affect the biological fitness of the offspring. Moreover, casein genes harbour a number of variants with suggested effects concerning traits such as the manufacturing properties of milk [1,35].…”

Section: Introductionmentioning

confidence: 99%

Geographic distribution of haplotype diversity at the bovine casein locus

et al. 2004

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-The genetic diversity of the casein locus in cattle was studied on the basis of haplotype analysis. Consideration of recently described genetic variants of the casein genes which to date have not been the subject of diversity studies, allowed the identification of new haplotypes. Genotyping of 30 cattle breeds from four continents revealed a geographically associated distribution of haplotypes, mainly defined by frequencies of alleles at CSN1S1 and CSN3. The genetic diversity within taurine breeds in Europe was found to decrease significantly from the south to the north and from the east to the west. Such geographic patterns of cattle genetic variation at the casein locus may be a result of the domestication process of modern cattle as well as geographically differentiated natural or artificial selection. The comparison of African Bos taurus and Bos indicus breeds allowed the identification of several Bos indicus specific haplotypes (CSN1S1*C-CSN2*A 2 -CSN3*A I / CSN3*H) that are not found in pure taurine breeds. The occurrence of such haplotypes in southern European breeds also suggests that an introgression of indicine genes into taurine breeds could have contributed to the distribution of the genetic variation observed.casein / haplotype / Bos taurus / Bos indicus / phylogeny

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Associations Between Casein Haplotypes and First Lactation Milk Production Traits in Finnish Ayrshire Cows

Cited by 89 publications

References 25 publications

Quantitative trait loci mapping in dairy cattle: review and meta-analysis

Quantitative trait loci mapping in dairy cattle: review and meta-analysis

Casein Haplotype Structure in Five Italian Goat Breeds

Geographic distribution of haplotype diversity at the bovine casein locus

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