Associations between cognitive impairment and quality of life in euthymic bipolar patients

Toyoshima, Kuniyoshi; Kako, Yuki; Toyomaki, Atsuhito; Shimizu, Yusuke; Tanaka, Teruaki; Nakagawa, Shin; Inoue, Takeshi; Martínez-Àran, Anabel; Vieta, Eduard

doi:10.1016/j.psychres.2018.11.061

Cited by 31 publications

(19 citation statements)

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“…Recent research has suggested that cognitive complaints and depression severity affect social function, although objective cognitive impairments do not affect social function in major depressive disorder [34]. A relationship between cognitive complaints and social function has been reported in euthymic bipolar disorder [35]. There is an important correlation between social function and cognitive function, especially subjective cognitive function.…”

Section: Introductionmentioning

confidence: 99%

Structural equation modeling approach to explore the influence of childhood maltreatment in adults

et al. 2020

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Background Childhood maltreatment affects social functioning in the general adult population. However, how child abuse affects functional disability in adulthood remains unknown. Thus, we investigated the correlation between child abuse, depressive symptoms, cognitive complaints, and functional disability in adult community volunteers. Methods Participants (N = 556) completed the Child Abuse and Trauma Scale, Patient Health Questionnaire-9, Cognitive Complaints in Bipolar Disorder Rating Assessment, and Sheehan Disability Scale. Multiple regression analyses and structural equation modeling were performed to evaluate scale correlations. Results Structural equation modeling showed that the direct effect of childhood maltreatment on depressive symptoms, the indirect effect of childhood maltreatment on cognitive function via depressive symptoms, and the indirect effects of childhood maltreatment on functional disability via depressive symptoms and via cognitive function were all significant. The direct effects of childhood maltreatment on cognitive function and functional disability were not significant. There was no significant association between variables. Limitations Cross-sectional designs cannot identify causal relationships between parameters. Participants were adult volunteers from the community; therefore, results may not be generalizable

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Section: Introductionmentioning

confidence: 99%

Structural equation modeling approach to explore the influence of childhood maltreatment in adults

et al. 2020

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“…Her ne kadar literatürde hasta yakınları ile kontroller arasında anlamlı fark saptamayan çalışmalar olsa da (6); BB olan hastalar ve yakınları arasında özellikle yanıt inhibisyonu ve planlama gibi yürütücü işlevler, sözel öğrenme, sözel bellek ve sözel çalışan bellek açısından benzerlik olduğu, bu işlev bozukluklarının BB için endofenotip adayı olabileceğini öne süren metaanaliz çalışmaları mevcuttur (7). Ayrıca güncel veriler mevcut bilişsel bozuklukların yaşam kalitesine olan olumsuz etkilerini de ortaya koymuş, konunun önemine tekrar vurgu yapmıştır (8,9). Bu nedenle bipolar bozuklukta bilişsel bozukluklar konusu güncelliğini korumaya devam edecektir ve bu alanda daha çok çalışmaya ihtiyaç olduğu görünmektedir.…”

Section: Introductionunclassified

Theory of mind and executive functions in bipolar disorder patients and their first-degree relatives (tur)

Duman¹,

Ateşçi²,

Topak³

et al. 2019

J Clin Psy

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Objective: In this study it is aimed to compare the theory of mind skills and executive functions in bipolar disorder patients and their first degree relatives with controls, and to demonstrate the relationship between executive functions and theory of mind. Method: 30 patients with euthymic bipolar I disorder, their first degree relatives, and 30 healthy controls were included in the study. Sociodemographic data form, Hamilton Depression Rating Scale, Young Mania Rating Scale, Wechsler Adults Intelligence Test were applied to all participants; Wisconsin Card Sorting Test, Stroop Test, Trail Making Test A and B, and Digit Span Test were applied to evaluate the executive functions; Reading the Mind in the Eyes Test, Hinting Task and Faux Pas Test were applied to evaluate the theory of mind skills. Results: There was not any significant difference between the groups in terms of theory of mind, although total scores were seen from bad to good in bipolar patients, first degree relatives and controls respectively. Patient group had significantly lower performance in Trail Making Test A, and DigitSpan Test inverse number scores. As the severity of disease increased, cognitive functions and the theory of mind were seen to be worsened. The theory of mind was related to executive functions. Discussion: In conclusion, we did not find significant losses in terms of theory of mind in bipolar patients and their first degree relatives. But bipolar patients had a deficiency in attention, psychomotor speed and verbal working memory; and theory of mind was related to executive functions.

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“…21 Regarding the Japanese version of COBRA, it correlates with processing speed, 20 and quality of life in patients with euthymic bipolar disorder. 17 In Japan, COBRA is a useful tool to assess subjective cognitive function in the general adult population. Our objective was to investigate the mediator effect of subjective cognitive function in the relationship between affective temperaments, depressive symptoms, and functional disability.…”

Section: Neurocognitive Complaints Assessmentsmentioning

confidence: 99%

“…1 The correlation between depressive symptoms, subjective cognitive function, and functional disability are significant not only in patients with mood disorder but also in the general population. 1,17 However, the impact of affective temperaments on subjective cognitive function in the general adult population remains unknown. In addition, it is unknown if subjective cognitive function mediates the effect of affective temperaments on functional disability.…”

Section: Introductionmentioning

confidence: 99%

<p>Does Subjective Cognitive Function Mediate the Effect of Affective Temperaments on Functional Disability in Japanese Adults?</p>

Toyoshima¹,

Inoue²,

Masuya³

et al. 2020

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Functional disability is affected by subjective cognitive function, depressive symptoms, and affective temperaments in adults. However, the role of subjective cognitive function as a mediator of affective temperaments in functional disability remains unknown. Therefore, we aimed to determine how subjective cognitive function mediates the effect of affective temperaments on functional disability in adults. Materials and Methods: A total of 544 participants completed the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto questionnaire version (TEMPS-A), the Patient Health Questionnaire-9 (PHQ-9), the cognitive complaints in bipolar disorder rating assessment (COBRA), and the Sheehan Disability Scale (SDS). The association among these instruments was evaluated by multiple regression and covariance structure analyses. Results: The structural equation model showed that the COBRA scores could be predicted directly by the four affective temperaments of the TEMPS-A (cyclothymic, depressive, irritable, and anxious) and indirectly by the PHQ-9. Moreover, the SDS score was predicted directly by these four affective temperaments and indirectly by the COBRA and PHQ-9. Conclusion: Subjective cognitive function mediates the effect of affective temperaments on functional disability in Japanese adults. However, the cross-sectional design may limit the identification of causal associations between the parameters. In the present study, the participants were from a specific community population; therefore, the results may not be generalizable to other communities.

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Associations between cognitive impairment and quality of life in euthymic bipolar patients

Cited by 31 publications

References 35 publications

Structural equation modeling approach to explore the influence of childhood maltreatment in adults

Structural equation modeling approach to explore the influence of childhood maltreatment in adults

Theory of mind and executive functions in bipolar disorder patients and their first-degree relatives (tur)

<p>Does Subjective Cognitive Function Mediate the Effect of Affective Temperaments on Functional Disability in Japanese Adults?</p>

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