Associations between cognitive performance and sigma power during sleep in children with attention-deficit/hyperactivity disorder, healthy children, and healthy adults

Bestmann, Arnika; Conzelmann, Annette; Baving, Lioba; Prehn-Kristensen, Alexander

doi:10.1371/journal.pone.0224166

Cited by 13 publications

(16 citation statements)

References 63 publications

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“…As an indicator of disturbed sleep’s effect on cognitive performance, an association between stage 2 sleep oscillations (characterized by sigma power) and cognitive performance was found in children with ADHD ( n = 17, aged 9–12 years), when a negative correlation between sigma power in the parietal area and IQ was found (Bestmann et al, 2019). Similarly, Um et al (2016) found that the percentage of stage 2 sleep in ADHD ( n = 28, 6–12 years) was negatively correlated with verbal IQ (WISC-III) and predicted response latency time in an evaluation of cognitive reflection-impulsivity.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Sleep and Circadian Rhythms in Children with Attention Deficit Hyperactivity Disorder

2021

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Objective: Children and adults with ADHD often report sleep disturbances that may form part of the etiology and/or symptomatology of ADHD. We review the evidence for sleep changes in children with ADHD. Methods: Systematic review with narrative synthesis assessing sleep and circadian function in children aged 5 to 13 years old with a diagnosis of ADHD. Results: 148 studies were included for review, incorporating data from 42,353 children. We found that sleep disturbances in ADHD are common and that they may worsen behavioral outcomes; moreover, sleep interventions may improve ADHD symptoms, and pharmacotherapy for ADHD may impact sleep. Conclusion: Sleep disturbance may represent a clinically important feature of ADHD in children, which might be therapeutically targeted in a useful way. There are a number of important gaps in the literature. We set out a manifesto for future research in the area of sleep, circadian rhythms, and ADHD.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review of Sleep and Circadian Rhythms in Children with Attention Deficit Hyperactivity Disorder

2021

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“…Raw scores were used for statistical analysis. Though KiTAP was originally designed and normalized on children, it has been validated for use in adults with full mutation FXS ( Knox et al, 2012 ), and raw scores have been used to compare adult control and non-control samples and in relation to EEG measures elsewhere ( Bestmann et al, 2019 ). The NIH Cognitive Toolbox was not available at start of the study, but has since shown convergent validity across tasks in an adult sample ( Hessl et al, 2016 ).…”

Section: Methodsmentioning

confidence: 99%

Evidence for Three Subgroups of Female FMR1 Premutation Carriers Defined by Distinct Neuropsychiatric Features: A Pilot Study

Schmitt

Dominick

et al. 2022

Front. Integr. Neurosci.

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Over 200 Cytosine-guanine-guanine (CGG) trinucleotide repeats in the 5′ untranslated region of the Fragile X mental retardation 1 (FMR1) gene results in a “full mutation,” clinically Fragile X Syndrome (FXS), whereas 55 – 200 repeats result in a “premutation.” FMR1 premutation carriers (PMC) are at an increased risk for a range of psychiatric, neurocognitive, and physical conditions. Few studies have examined the variable expression of neuropsychiatric features in female PMCs, and whether heterogeneous presentation among female PMCs may reflect differential presentation of features in unique subgroups. In the current pilot study, we examined 41 female PMCs (ages 17–78 years) and 15 age-, sex-, and IQ-matched typically developing controls (TDC) across a battery of self-report, eye tracking, expressive language, neurocognitive, and resting state EEG measures to determine the feasibility of identifying discrete clusters. Secondly, we sought to identify the key features that distinguished these clusters of female PMCs. We found a three cluster solution using k-means clustering. Cluster 1 represented a psychiatric feature group (27% of our sample); cluster 2 represented a group with executive dysfunction and elevated high frequency neural oscillatory activity (32%); and cluster 3 represented a relatively unaffected group (41%). Our findings indicate the feasibility of using a data-driven approach to identify naturally occurring clusters in female PMCs using a multi-method assessment battery. CGG repeat count and its association with neuropsychiatric features differ across clusters. Together, our findings provide important insight into potential diverging pathophysiological mechanisms and risk factors for each female PMC cluster, which may ultimately help provide novel and individualized targets for treatment options.

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“…In total, 63 records met the initial criteria and advanced to full-text screening. Of the 63 records, 10 met the full criteria for data extraction and were retained for the systematic review [ 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ]. As seen in Figure 1 , the most common reason for study exclusion was a lack of objective cognitive measures.…”

Section: Resultsmentioning

confidence: 99%

The Associations between the Homeostatic and Circadian Sleep Processes and the Neurobehavioral Functioning (NBF) of Individuals with ADHD—A Systematic Review

Gruber,

Gauthier-Gagné,

Little

et al. 2023

Brain Sciences

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The objective of the present review was to systematically examine associations between perturbations of the homeostatic or circadian sleep processes and the neurobehavioral functioning (NBF) of individuals with ADHD. Electronic databases were searched for articles published between December 2013 and March 2023. Studies were included if they used objective measures of NBF, used objective or subjective measures of sleep, and focused on individuals with ADHD. Ten studies met these inclusion criteria. Of these, eight studies found perturbations in the interplay between NBF and Process S or Process C, and three studies did not. The quality of the studies was degraded because they failed to address key factors that affect the sleep processes and by the presence of methodological weaknesses. Our review suggests that homeostatic and circadian sleep processes are associated with NBF in individuals with ADHD. However, to confirm the validity of this conclusion, future studies should examine or control for confounders and utilize experimental designs that allow causality to be inferred.

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Associations between cognitive performance and sigma power during sleep in children with attention-deficit/hyperactivity disorder, healthy children, and healthy adults

Cited by 13 publications

References 63 publications

A Systematic Review of Sleep and Circadian Rhythms in Children with Attention Deficit Hyperactivity Disorder

A Systematic Review of Sleep and Circadian Rhythms in Children with Attention Deficit Hyperactivity Disorder

Evidence for Three Subgroups of Female FMR1 Premutation Carriers Defined by Distinct Neuropsychiatric Features: A Pilot Study

The Associations between the Homeostatic and Circadian Sleep Processes and the Neurobehavioral Functioning (NBF) of Individuals with ADHD—A Systematic Review

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