Associations between coronary artery stenosis detected by coronary computed tomography angiography and the characteristics of health checkup examinees in the Republic of Korea

Noh, Dongho; Kim, S.

doi:10.1016/j.radi.2019.06.001

Cited by 1 publication

(1 citation statement)

References 17 publications

(16 reference statements)

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“…Fifth, previous studies/guidelines did not recommend cardiac CT angiography as a screening test in asymptomatic low-risk subjects [39,40]. However, several studies have retrospectively demonstrated that male gender, diabetes mellitus, and smoking amount are predictors of subclinical coronary atherosclerosis or noncalcified plaque, even in young adults or health checkup populations [41][42][43][44]. Our study used a similar retrospective cohort design to investigate the association between the degree of fatty liver and coronary atherosclerosis, independently of traditional cardiovascular risk factors (FRS percentile).…”

Section: Discussionmentioning

confidence: 99%

Severe, but not mild to moderate, non-alcoholic fatty liver disease associated with increased risk of subclinical coronary atherosclerosis

Hsiao

Teng

et al. 2021

BMC Cardiovasc Disord

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Background Non-alcoholic fatty liver disease (NAFLD) is associated with high risk of cardiovascular disease. The prevalence is increasing to 45–65% in the general population with routine health check-up, and most subjects have the mild degree NAFLD in recent years. Moreover, there are no studies on the association between NAFLD severity and coronary atherosclerosis in the real-world setting by ultrasonography. Methods The aim of this study was to determine the relationship between the severity of NAFLD and subclinical coronary atherosclerosis. Overall, 817 subjects meet criteria for NAFLD were enrolled in the retrospective cohort study (155 subjects were excluded). The severity of NAFLD was divided into the normal, mild, moderate and severe degree based on the finding of abdominal ultrasonography. The assessment of coronary atherosclerosis was based on CAC scan/coronary CT angiography finding in terms of CAC score ≧ 100, CAC score ≧ 400, CAD-RADS ≧ 3 and presence of vulnerable plaque(s). Results A significant linear trend was observed between the severity of NAFLD and subclinical coronary atherosclerosis. Compared with the reference group (including normal, mild, and moderate NAFLD), severe degree NAFLD was the independently associated risk of subclinical coronary atherosclerosis in term of CAC score ≧ 100, CAC score ≧ 400, CAD-RADS ≧ 3 and presence of vulnerable plaque(s) based on binary logistic regression after adjustment for FRS score and body fat percentage. Conclusions Severe degree, but not mild to moderate, was associated with high risk of subclinical coronary atherosclerosis, independently of FRS score and body-fat percentage.

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