Associations between daytime and nighttime plasma orexin A levels and cognitive function in patients with obstructive sleep apnea

Zhu, Jing; Zeng, Zhaofu; Xiong, Mengqing; Mo, Huaheng; Jin, Meng; Hu, Ke

doi:10.1007/s41105-022-00387-4

Cited by 3 publications

(3 citation statements)

References 43 publications

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“…Table 1 reports the data for the variables of fourteen studies from the thirteen articles [ 40 , 41 , 42 , 43 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 ] included in the meta-analysis. With regard to the studies reporting OM-1 levels, four were reported among Caucasians and two among Asians, and for the studies reporting OXA levels, three were among Caucasians and five among Asians.…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Mohammadi

Sadeghi

Tajmiri

et al. 2023

Life

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Background and objective: Obstructive sleep apnea (OSA) can be related to changes in the levels of adipokines and neuropeptides, which in turn may affect the energy balance components of neuronal cells. Herein, a systematic review and meta-analysis checked the changes in serum/plasma levels of omentin-1 (OM-1: an adipokine) and orexin-A (OXA: a neuropeptide) in adults (age > 18 years old) with OSA (aOSA) compared to controls. Materials and methods: Four databases (Cochrane Library, PubMed, Web of Science, and Scopus) were systematically searched until 14 November 2022, without any restrictions. The Joanna Briggs Institute (JBI) critical appraisal checklist adapted for case–control studies was used to assess the quality of the papers. The effect sizes were extracted using the Review Manager 5.3 software for the blood levels of OM-1 and OXA in aOSA compared with controls. Results: Thirteen articles, with six studies for OM-1 levels and eight for OXA levels, were included. The pooled standardized mean differences were −0.85 (95% confidence interval (CI): −2.19, 0.48; p = 0.21; I2 = 98%) and −0.20 (95%CI: −1.16, 0.76; p = 0.68; I2 = 96%) for OM-1 and OXA levels, respectively. Among the studies reporting OM-1, five were high and one was moderate quality. Among the studies reporting OXA, six were moderate, one was high, and one was low quality. Based on the trial sequential analysis, more participants are needed to confirm the pooled results of the analyses of blood levels of OM-1 and OXA. In addition, the radial plot showed outliers as significant factors for high heterogeneity. Conclusions: The main findings indicated a lack of association between the blood levels of OM-1 and OXA and OSA risk. Therefore, OM-1 and OXA did not appear to be suitable biomarkers for the diagnosis and development of OSA.

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Section: Resultsmentioning

confidence: 99%

“…Three studies [ 42 , 59 , 63 ] showed a reduced significant level of OXA in aOSA compared to controls. In contrast, three articles [ 43 , 57 , 58 ] reported an elevated significant level of OXA in aOSA compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Mohammadi

Sadeghi

Tajmiri

et al. 2023

Life

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“…OSA is commonly associated with a lack of exercise. Levels of nighttime plasma levels and cognitive functioning in OSA patients have been traced [20]. ROC analysis indicated high specificity and sensitivity of nighttime plasma levels and cognitive functioning [20].…”

Section: Impact Of Osamentioning

confidence: 99%

Cognitive and Emotional Factors Related to Obstructive Sleep Apnea Diagnoses: A Brief Review

Sexton-Radek

2023

Health

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Sleep apnea is a clinical condition characterized by cessation of breathing in the sleeper due to pharyngeal airway closure. The reduction in air exchange results in decreased cerebral blood circulation with consequential behavioral deficits cognitively and emotionally. Untreated sleep apnea is associated with chronic illnesses of depression, cardiovascular disorder, obesity and diabetes mellitus. Measured cognitive behavior before and following CPAP treatment demonstrates the cognitive deficit as the effectiveness of CPAP treatment. Emotional factors related to sleep apnea diagnosis and adherence to treatment are facilitated in patients with cognitive behavior therapy (CBT) interventions by sleep specialists. This is a brief review paper that presents findings about cognition and emotional factors related to sleep apnea. This is a brief review paper.

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Assessment of biological rhythm disturbances and emotion recognition in individuals with or without obstructive sleep apnea syndrome: The role of eating patterns

Aksu,

Özdemir,

Çaman

et al. 2023

Biological Rhythm Research

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Associations between daytime and nighttime plasma orexin A levels and cognitive function in patients with obstructive sleep apnea

Cited by 3 publications

References 43 publications

Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Cognitive and Emotional Factors Related to Obstructive Sleep Apnea Diagnoses: A Brief Review

Assessment of biological rhythm disturbances and emotion recognition in individuals with or without obstructive sleep apnea syndrome: The role of eating patterns

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