Associations between habitual diet, platelet function, fibrinogen and factor VII coagulant activity in young Finns

Mutanen, Marja; Krusius, Tom; ̈nen, L. Ra ̈sa; Freese, Riitta; ̈nen, M. Po ̈yho; Vahtera, Elina; Viikari, Jorma; �kerblom, H. K.

doi:10.1016/0021-9150(94)94071-1

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“…In a cross-sectional Finnish study the intake of rye (but not ®ber) was inversely associated with plasma FVIIc in young subjects (15 ± 30 y; Mutanen et al, 1995), suggesting that the effective component in rye could be something other than ®ber, e.g. phytochemicals present in rye.…”

Section: Discussionmentioning

confidence: 96%

Similar responses in hemostatic factors after consumption of wholemeal rye bread and low-fiber wheat bread

et al. 2000

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Objective: Both epidemiological and experimental evidence suggests a protective effect of dietary ®ber against disease, such as cancer and cardiovascular disease. The effects of ®ber on lipoproteins are modest, indicating that other mechanisms may be involved. As the hemostatic effects of different types of ®ber are poorly known, we compared the effects of wholemeal rye bread and low-®ber wheat bread on factors related to coagulation, ®brinolysis and platelet function. Design: Subjects consumed rye and wheat bread as part of their habitual diet in a cross-over manner for 4 weeks, with a 4 week washout period between the diet periods. Subjects: Forty healthy subjects (18 men, 22 women), aged 43 AE 2 y. Results: Mean daily intake of ®ber during the rye bread period was 31 g for men and 26 g for women, while the respective ®gures for the wheat bread period were 15 g and 12 g. However, no signi®cant differences between the two periods were seen in factor VII coagulant activity (FVIIc), ®brinogen, prothrombin fragments 1 2 (F1 2), tissue plasminogen activator (tPA) plasminogen activator inhibitor 1 (PAI-1) or 2,3,-dinor-thromboxane B 2 . Fibrin degradation products, D-dimers, were slightly lower after the wheat period (P 0.046). Conclusions:The results indicate that wheat and rye bread do not differ in their effects on coagulation, ®brinolysis or platelet function.

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Section: Discussionmentioning

confidence: 96%