Associations Between MTHFR Polymorphisms and the Risk of Potentially Malignant Oral Disorders

Abstract

Our findings suggest that the T-allele-carrying MTHFR C677T genotype or haplotype may reduce the risk of PMODs. However, these observations require further confirmation using larger samples.

Methylenetetrahydrofolate reductase polymorphisms in dental caries-induced pulp inflammation and regeneration of dentine-pulp complex: Future perspectives

“…MTHFR-SNPs are associated with several disorders including cardiovascular-disease, cancers, neural tube defects, Alzheimer’s-disease and dental complications ( Senghore et al, 2018 , Rozen, 2000 , Stover et al, 2015 ). So far, the relationship between MTHFR-SNPs and dental disorders, specifically, tooth decay (DC and pulpitis) and periodontal disease are understudied.…”