Associations between IL-23R gene polymorphism (rs10889677 A/C) and ankylosing spondylitis and rheumatoid arthritis susceptibility: A meta-analysis with trial sequential analysis

Zhang, Tao; Yu, Lingxiang; Shao, Ming; Wu, Ye; Wang, Jinian; Deng, Yujie; Ni, Man; Sun, Xiaoya; Chen, Yuting; Xu, Shanshan; Ma, Yubo; Shuai, Zongwen; Pan, Faming

doi:10.1080/08916934.2022.2076837

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…Another metanalysis evaluated the association between IL-23R polymorphisms and autoimmune diseases susceptibility. The results showed that IL-23R (rs10889677 A/C) A allele was a risk gene for AS in the general population, especially in Caucasians and that AA genotype increased the risk of AS in Mongolians (21). A role of IL-23 in the pathogenesis and in the level of activity of AS was confirmed by a meta-analysis by Lee and colleagues (22).…”

Section: Genetics and Pathogenesismentioning

confidence: 85%

“…• Some SNPs of both ERAP1/2, TNF-α, IL-1A, IL-23A-R and CTLA-4 genes seem to be associated with a higher probability of developing AS, with different pattern of risk based on ethnicity (16)(17)(18)(19)(20)(21)(22)(23)(24)(25). • An imbalance in lymphocytes subsets seems to be involved in ax-SpA pathogenesis and the administration of symbiotics does not seem to correct it (26-28).…”

Section: Take-home Messagesmentioning

confidence: 99%

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Axial spondyloarthritis: one year in review 2023

Fattorini,

Gentileschi,

Cigolini

et al. 2023

Clinical and Experimental Rheumatology

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Axial spondyloarthritides (axSpA) are a group of systemic autoimmune diseases, characterised by an inflammatory involvement of the axial skeleton, which, in the earlier phases, cannot be detected by conventional radiology, but only by magnetic resonance imaging, thus defining the so-called non-radiographic axSpA (nr-axSpA). The initial osteitis then tends to complicate into bone reabsorption and aberrant bone deposition, which then determines the ankylosis of the axial skeleton in the latest phases of the disease. Peripheral joints may also be affected, enthesitis being its more characteristic manifestation. The radiographic form corresponds to ankylosing spondylitis which, with psoriatic arthritis, is the best-known subtype of SpA. AxSpA are rarely associated to laboratory abnormalities and are usually complicated by the presence of both extra-articular manifestations (particularly acute anterior uveitis, psoriasis and inflamatory bowel disease) and comorbidities, with a subsequent higher risk for patients of an impaired quality of life. In this paper we reviewed the literature on axSpA of 2021 and 2022 (Medline search of articles published from 1st January 2021 to 31st December 2022).

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Section: Genetics and Pathogenesismentioning

confidence: 85%

Section: Take-home Messagesmentioning

confidence: 99%

Axial spondyloarthritis: one year in review 2023

Fattorini,

Gentileschi,

Cigolini

et al. 2023

Clinical and Experimental Rheumatology

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“…Research also indicates that IL23R is related to the prognosis of gastric cancer and non-small cell lung carcinoma ( 11 , 12 ). IL23R is also associated with other immune-related diseases, such as ankylosing spondylitis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease ( 13 - 15 ). In a recent study, it was reported that a higher baseline level of IL-23 could improve the clinical results of atezolizumab combined with cobimetinib in the treatment of advanced biliary tract cancers ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

IL23R as an indicator of immune infiltration and poor prognosis in intrahepatic cholangiocarcinoma: a bioinformatics analysis

Zhang,

Yang,

Chen

et al. 2023

Transl Cancer Res

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Background Although the incidence of intrahepatic cholangiocarcinoma (CHOL) is low, the prognosis is very poor. The expression level of interleukin 23 receptor ( IL23R ) is linked to the occurrence and development of cancers. This study aimed to identify the role of IL23R in CHOL using bioinformatics tools and experimental validation. Methods Circular RNA (circRNA), microRNA (miRNA), and messenger RNA (mRNA) datasets were obtained from the Gene Expression Omnibus (GEO) database, and R software was used for data analysis and visualization. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to conduct functional enrichment analysis, which was verified with gene set enrichment analysis software. Clinical data were obtained from The Cancer Genome Atlas (TCGA), and survival analyses were performed using the DriverDBv3 database and the Gene Expression Profiling Interactive Analysis website. The TIMER2.0 database provided us for immune cell infiltration analysis results of IL23R . Real-time quantitative polymerase chain reaction (RT-qPCR) was used for IL23R expression verification. Results Differentially expressed (DE) mRNAs were enriched in phosphoinositide 3-kinase-serine/threonine kinase signaling pathway, immune-related tumor microenvironment (TME), and amino acid metabolism, etc. In addition, expression of IL23R was associated with immune infiltration-related cells. Furthermore, a circRNA-miRNA- IL23R network and a IL23R protein-protein interaction network were established. Most importantly, IL23R , as a prognostic gene, was found to have a low expression in CHOL. Conclusions A circRNA-miRNA- IL23R network was identified, and it was found that IL23R may be a prognostic and immune-related biomarker in CHOL, which is worthy of further exploration.

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“…Existen otros genes no antígeno del leucocito humano estudiados como la proteína tirosina fosfatasa no receptora tipo 22 (PTPN22) [5,6] representando en este grupo de moléculas la de mayor susceptibilidad para artritis reumatoide, la cual está relacionada con riesgo para otras enfermedades autoinmunes como diabetes mellitus tipo 1, artritis idiopática juvenil, lupus eritematoso sistémico, síndrome de Sjogren, enfermedad tiroidea autoinmune, vitíligo y diferentes formas de vasculitis. Igualmente se ha analizado polimorfismo del gen antígeno-4 de linfocitos T citotóxicos (CTLA-4) [7,8] y la desregulación del receptor de interleucina-23 (IL-23R) como predisposición para artritis reumatoide, y otras condiciones reumáticas como la espondilitis anquilosante y lupus eritematoso sistémico [9,10]. Sin embargo, no explican del todo los mecanismos fisiopatológicos de la enfermedad, debido a las características de patrón de herencia poligénica.…”

Section: Introductionunclassified

Effect of epigenetics on rheumatoid arthritis

Rada¹,

Mestre²,

Morales³

2023

Medwave

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Rheumatoid arthritis is an autoimmune and inflammatory disease that predominantly affects the diarthrodial joints. In this pathology, environmental or behavioral factors can act in synergy with genetic predisposition, accelerating the onset and severity of the disease. This link between the environment and the genome is mediated by epigenetic marks on deoxyribonucleic acid, including its methylation, histone modification, and noncoding ribonucleic acid-mediated regulation. Epigenetics can generate heritable phenotypic changes, which are not determined by modifications in the deoxyribonucleic acid sequence and are therefore reversible. Therefore, diet, medications and other environmental factors would have the ability to modulate them. The identification of a specific epigenetic dysregulation can offer a better understanding of the pathophysiology of the disease and positively influence the prevention, diagnosis and development of new therapeutic targets. Rheumatoid arthritis is an autoimmune and inflammatory disease that predominantly affects the diarthrodial joints. In this pathology, environmental or behavioral factors can act in synergy with genetic predisposition, accelerating the onset and severity of the disease. This link between the environment and the genome is mediated by epigenetic marks on deoxyribonucleic acid, including its methylation, histone modification, and noncoding ribonucleic acid-mediated regulation. Epigenetics can generate heritable phenotypic changes, which are not determined by modifications in the deoxyribonucleic acid sequence and are therefore reversible. Therefore, diet, medications and other environmental factors would have the ability to modulate them. The identification of a specific epigenetic dysregulation can offer a better understanding of the pathophysiology of the disease and positively influence the prevention, diagnosis and development of new therapeutic targets.

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Associations between IL-23R gene polymorphism (rs10889677 A/C) and ankylosing spondylitis and rheumatoid arthritis susceptibility: A meta-analysis with trial sequential analysis

Cited by 5 publications

References 26 publications

Axial spondyloarthritis: one year in review 2023

Axial spondyloarthritis: one year in review 2023

IL23R as an indicator of immune infiltration and poor prognosis in intrahepatic cholangiocarcinoma: a bioinformatics analysis

Effect of epigenetics on rheumatoid arthritis

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