Associations between interleukin-10 polymorphisms and susceptibility to psoriasis: a meta-analysis

Lee, Young Ho; Choi, Sung Jae; Ji, Jong Dae; Song, Gwan Gyu

doi:10.1007/s00011-012-0458-2

Cited by 28 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are several polymorphisms associated with risk of psoriasis, including signal transducer and activator of transcription 4 (STAT4), TaqI polymorphisms in vitamin D receptor (VDR) gene, interleukin-10 (IL-10) polymorphisms and LCE3B genes [35,36]. But no studies investigated the gene-gene interactions in the associations of TNF-α 308 G/A and 238 G/A polymorphisms with psoriasis risk.…”

Section: Discussionmentioning

confidence: 99%

Associations between Tumor Necrosis Factor-α Polymorphisms and Risk of Psoriasis: A Meta-Analysis

Liu

Cai

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

BackgroundTumor necrosis factor-α (TNF-α) may play an important role in the recalcitrant inflammatory and hyperproliferative dermatosis of psoriasis, and there may be a relationship between TNF-α polymorphisms and psoriasis risk. MethodsWe performed a meta-analysis to evaluate the associations between TNF-α polymorphisms and psoriasis. Electronic searches of Pubmed, Embase, and Web of Science were performed for all publications on the associations between TNF-α polymorphisms and psoriasis through September 26, 2012. The pooled odds ratios (ORs) with their 95% confidence interval (95%CIs) were calculated to assess the associations.ResultsSixteen case-control studies with a total of 2,253 psoriasis cases and 1,947 controls on TNF-α 308 G/A polymorphism and fourteen studies on TNF-α 238 G/A polymorphism with 2,104 cases and 1,838 controls were finally included into the meta-analysis. Overall, TNF-α 308 G/A polymorphism was significantly associated with decreased risk of psoriasis under three genetic comparison models (for A versus G: fixed-effects OR 0.71, 95%CI 0.62-0.82, P < 0.001; for AG versus GG: fixed-effects OR 0.67, 95%CI 0.57-0.78, P < 0.001; for AA/AG versus GG: fixed-effects OR 0.67, 95%CI 0.58-0.78, P < 0.001). In addition, TNF-α 238 G/A polymorphism was associated with increased risk of psoriasis under three genetic models (for A versus G: fixed-effects OR 2.46, 95%CI 2.04-2.96, P < 0.001; for AG versus GG: fixed-effects OR 2.69, 95%CI 2.20-3.28, P < 0.001; for AA/AG versus GG: fixed-effects OR 2.68, 95%CI 2.20-3.26, P < 0.001). Subgroup analysis by ethnicity identified a significant association between TNF-α 308 G/A polymorphism and decreased risk of psoriasis in both Caucasians and Asians and a significant association between TNF-α 238 G/A polymorphism and increased risk of psoriasis in Caucasians.ConclusionsThe meta-analysis suggests that TNF-α 308 G/A polymorphism is associated with decreased risk of psoriasis, while TNF-α 238 G/A is associated with increased risk of psoriasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Associations between Tumor Necrosis Factor-α Polymorphisms and Risk of Psoriasis: A Meta-Analysis

Liu

Cai

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…25 A meta-analysis of eight studies involving 1018 psoriasis patients and 1186 controls shows that the IL-10-1082 G/A polymorphism confers susceptibility to psoriasis in Asians, and suggests that the IL-10 promoter -1082 polymorphism has an ethnicity-specific effect. 26 The molecular mechanism of the association between ACE I/D polymorphism and the risk of psoriasis is still relatively unclear. ACE and its related substrates or products are known to have wide-ranging effects on cutaneous immune and inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to psoriasis in a Chinese population

Yang

Zhang

et al. 2013

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

Psoriasis is a common, chronic inflammatory skin disease characterized by keratinocyte hyperproliferation and increased blood flow induced by the stimulation of tissueresident immune cells by markedly altered cutaneous cytokine profiles. 1 Psoriasis affects approximately 2% of the general population. 2 It is a complex, multifactorial disease. Genetic as well as environmental factors contribute to the susceptibility and severity of psoriasis. Although the multifactorial etiology of psoriasis is well established, family and twin studies indicate a strong genetic component. 3 During the past five years, genome-wide association studies (GWAS), primarily based on single nucleotide polymorphism markers, have identified many loci as potential psoriasis susceptibility regions. 4,5 Angiotensin-converting enzyme (ACE) is an important circulating enzyme in the renin-angiotensin-aldosterone system (RAAS). 6 ACE is expressed in a wide range of tissues including skin, vascular endothelium and immune cells. The relationship between the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and psoriasis has previously been studied mainly in Caucasians and only once in Asians. The aim of this study is to evaluate the association between the ACE I/D polymorphism and the risk of psoriasis in a Chinese population. Materials and methods:The study population consisted of 668 psoriasis patients and 668 matched control subjects. The ACE I/D gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results:The frequency of the ACE II genotype (odds ratio (OR) = 1.32, 95% confidence interval (CI) = 1.06, 1.63; P = 0.01) and I allele (OR = 1.25, 95% CI = 1.06, 1.48; P = 0.01) in patients with psoriasis was significantly higher than that in the control group. And the D allele frequency in patients with psoriasis was significantly lower (OR = 0.80, 95% CI = 0.68, 0.95; P = 0.01) than that in the control group. When stratified by family history, the frequency of the DD genotype was marginally significantly lower in patients with a positive family history of psoriasis (familial psoriasis) than in those with negative (sporadic psoriasis) (OR = 0.47, 95% CI = 0.23, 0.97; P = 0.04). When stratified by onset of the disease, type of psoriasis and the severity of psoriasis, no statistically significant result was observed. Conclusion: Our study suggested that the ACE II genotype and I allele might confer susceptibility to psoriasis in a Chinese population.

show abstract

“…analysed three SNPs at the IL10 5ʹ flanking region [−1082 (rs1800896), −592 (rs1800872), −819C/T (rs1800871)] and identified that the IL10 ACC haplotype is associated with lower levels of disease activity and ATA haplotype with persistent eruption . The significant association of the IL10 ‐1082G allele with psoriasis ( P = 0·011) has been reported in a meta‐analysis involving Asian patients with psoriasis ( N = 1018) and controls ( N = 1186) …”

Section: Discussionmentioning

confidence: 86%

“…24 The significant association of the IL10-1082G allele with psoriasis (P = 0Á011) has been reported in a meta-analysis involving Asian patients with psoriasis (N = 1018) and controls (N = 1186). 53 Associations between IL19, IL20 and IL24 polymorphisms and psoriasis have also been assessed. Some studies found a significant association between psoriasis and IL19 SNP rs2243188, IL20 SNP rs2981572 and IL20 SNP rs1518108 in a cohort of unrelated white patients with psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-10 family cytokines pathway: genetic variants and psoriasis

et al. 2017

View full text Add to dashboard Cite

This study presents a novel finding that the combination of the two SNPs, IL10 (rs1554286) and IL20 (rs1518108), is associated with a reduced risk of psoriasis. Our results indicate that genetic variants of the immunomodulatory IL10 and IL20 genes may offer a protective effect in Europeans from Russia. Independent studies are required to verify the results and find a possible functional explanation.

show abstract

Associations between interleukin-10 polymorphisms and susceptibility to psoriasis: a meta-analysis

Abstract: This meta-analysis shows that the IL-10-1082 G/A polymorphism confers susceptibility to psoriasis in Asians, and suggests that the IL-10 promoter -1082 polymorphism has an ethnicity-specific effect.

Cited by 28 publications

References 32 publications

Associations between Tumor Necrosis Factor-α Polymorphisms and Risk of Psoriasis: A Meta-Analysis

Associations between Tumor Necrosis Factor-α Polymorphisms and Risk of Psoriasis: A Meta-Analysis

Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to psoriasis in a Chinese population

Interleukin-10 family cytokines pathway: genetic variants and psoriasis

Contact Info

Product

Resources

About