Associations between internal exposure levels of persistent organic pollutants in adipose tissue and deep infiltrating endometriosis with or without concurrent ovarian endometrioma

Ploteau, Stéphane; Cano-Sancho, Germán; Volteau, Christelle; Legrand, Arnaud; Vénisseau, Anaïs; Vacher, Vincent; Marchand, Philippe; Bizec, Bruno Le; Antignac, Jean‐Philippe

doi:10.1016/j.envint.2017.08.019

Cited by 44 publications

(44 citation statements)

References 63 publications

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“…Exposure in the case–control studies was much lower than in Seveso: Six studies reported no difference in blood levels of PCDD/Fs and DL‐PCBs between cases and controls (Pauwels et al., ; Fierens et al., ; De Felip et al., ; Niskar et al., ; Porpora et al., ; Cai et al., ) One reported lower levels in cases than in controls (Tsukino et al., ) Four reported higher levels in endometriosis cases than in controls (Heilier et al., ; Simsa et al., ; Martínez‐Zamora et al., ; Ploteau et al., ). …”

Section: Assessmentmentioning

confidence: 99%

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

Knutsen¹,

Alexander²,

Barregård³

et al. 2018

EFS2

143

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The European Commission asked EFSA for a scientific opinion on the risks for animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in feed and food. The data from experimental animal and epidemiological studies were reviewed and it was decided to base the human risk assessment on effects observed in humans and to use animal data as supportive evidence. The critical effect was on semen quality, following pre‐ and postnatal exposure. The critical study showed a NOAEL of 7.0 pg WHO2005‐TEQ/g fat in blood sampled at age 9 years based on PCDD/F‐TEQs. No association was observed when including DL‐PCB‐TEQs. Using toxicokinetic modelling and taking into account the exposure from breastfeeding and a twofold higher intake during childhood, it was estimated that daily exposure in adolescents and adults should be below 0.25 pg TEQ/kg bw/day. The CONTAM Panel established a TWI of 2 pg TEQ/kg bw/week. With occurrence and consumption data from European countries, the mean and P95 intake of total TEQ by Adolescents, Adults, Elderly and Very Elderly varied between, respectively, 2.1 to 10.5, and 5.3 to 30.4 pg TEQ/kg bw/week, implying a considerable exceedance of the TWI. Toddlers and Other Children showed a higher exposure than older age groups, but this was accounted for when deriving the TWI. Exposure to PCDD/F‐TEQ only was on average 2.4‐ and 2.7‐fold lower for mean and P95 exposure than for total TEQ. PCDD/Fs and DL‐PCBs are transferred to milk and eggs, and accumulate in fatty tissues and liver. Transfer rates and bioconcentration factors were identified for various species. The CONTAM Panel was not able to identify reference values in most farm and companion animals with the exception of NOAELs for mink, chicken and some fish species. The estimated exposure from feed for these species does not imply a risk.

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Section: Assessmentmentioning

confidence: 99%

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

Knutsen¹,

Alexander²,

Barregård³

et al. 2018

EFS2

143

View full text Add to dashboard Cite

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“…Relatively few studies have explored the role of EDCs in endometriosis. However, its association has been reported with higher blood or urinary levels of BPA ( 94 , 100 ), various phthalates ( 101 – 103 ) and organochlorine pesticides ( 104 , 105 ). On the other hand, no association or inverse association with phthalates was observed in studies on infertile Japanese women and American women, respectively ( 106 , 107 ).…”

Section: Edcs: Female and Male Reproductive Healthmentioning

confidence: 99%

Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases

Kumar

Sarma

Shubham

et al. 2020

Front. Public Health

239

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The exponential growth of pollutant discharges into the environment due to increasing industrial and agricultural activities is a rising threat for human health and a biggest concern for environmental health globally. Several synthetic chemicals, categorized as potential environmental endocrine-disrupting chemicals (EDCs), are evident to affect the health of not only livestock and wildlife but also humankind. In recent years, human exposure to environmental EDCs has received increased awareness due to their association with altered human health as documented by several epidemiological and experimental studies. EDCs are associated with deleterious effects on male and female reproductive health; causes diabetes, obesity, metabolic disorders, thyroid homeostasis and increase the risk of hormone-sensitive cancers. Sewage effluents are a major source of several EDCs, which eventually reach large water bodies and potentially contaminate the drinking water supply. Similarly, water storage material such as different types of plastics also leaches out EDCs in drinking Water. Domestic wastewater containing pharmaceutical ingredients, metals, pesticides and personal care product additives also influences endocrine activity. These EDCs act via various receptors through a variety of known and unknown mechanisms including epigenetic modification. They differ from classic toxins in several ways such as low-dose effect, non-monotonic dose and trans-generational effects. This review aims to highlight the hidden burden of EDCs on human health and discusses the non-classical toxic properties of EDCs in an attempt to understand the magnitude of the exposome on human health. Present data on the environmental EDCs advocate that there may be associations between human exposure to EDCs and several undesirable health outcomes that warrants further human bio-monitoring of EDCs.

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“…For example, prenatal exposure to diethylstilbestrol leads to an 80% increased risk of developing endometriosis in women from the National Health and Nutrition Examination Survey (NHANES II) cohort who had not previously been diagnosed with infertility or cancer (Missmer et al 2004 ). In addition, associations between endometriosis and various chemicals have been observed in case–control studies, including polychlorinated biphenyls, polybrominated diphenyl ethers, and various organochlorine pesticides (Ploteau et al 2017 ; Upson et al 2013 ).…”

Section: Ovarian Pathologiesmentioning

confidence: 99%

Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

et al. 2020

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Modern living challenges female reproductive health. We are witnessing a rise in reproductive disorders and drop in birth rates across the world. The reasons for these manifestations are multifaceted and most likely include continuous exposure to an ever-increasing number of chemicals. The cause–effect relationships between chemical exposure and female reproductive disorders, however, have proven problematic to determine. This has made it difficult to assess the risks chemical exposures pose to a woman’s reproductive development and function. To address this challenge, this review uses the adverse outcome pathway (AOP) concept to summarize current knowledge about how chemical exposure can affect female reproductive health. We have a special focus on effects on the ovaries, since they are essential for lifelong reproductive health in women, being the source of both oocytes and several reproductive hormones, including sex steroids. The AOP framework is widely accepted as a new tool for toxicological safety assessment that enables better use of mechanistic knowledge for regulatory purposes. AOPs equip assessors and regulators with a pragmatic network of linear cause–effect relationships, enabling the use of a wider range of test method data in chemical risk assessment and regulation. Based on current knowledge, we propose ten putative AOPs relevant for female reproductive disorders that can be further elaborated and potentially be included in the AOPwiki. This effort is an important step towards better safeguarding the reproductive health of all girls and women.

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Associations between internal exposure levels of persistent organic pollutants in adipose tissue and deep infiltrating endometriosis with or without concurrent ovarian endometrioma

Cited by 44 publications

References 63 publications

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases

Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

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