Associations between maternal phthalate exposure and cord sex hormones in human infants

Lin, Lung Cheng; Wang, Shu Li; Chang, Yu-Tang; Huang, Po Chin; Cheng, Joan Tin; Su, Pen Hua; Liao, Pao Chi

doi:10.1016/j.chemosphere.2010.12.079

Cited by 117 publications

(60 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…estrogenic, and endocrine-disrupting properties (Jobling et al 1995;Blom et al 1998;Wang et al 2015b). Some of them have been reported to show developmental and reproductive toxicity to humans and animals (Lin et al 2011;Hsu et al 2014). PAEs have been listed as top-priority environmental pollutants by the US Environment Protection Agency (US EPA), the European Union, and the China National Environmental Monitoring Center (Wang et al 1995).…”

Section: Responsible Editor: Gerald Thouandmentioning

confidence: 99%

Biodegradation of phthalic acid esters by a newly isolated Mycobacterium sp. YC-RL4 and the bioprocess with environmental samples

Ren

Yang

Nahurira

et al. 2016

Environ Sci Pollut Res

View full text Add to dashboard Cite

Bacterial strain YC-RL4, capable of utilizing phthalic acid esters (PAEs) as the sole carbon source for growth, was isolated from petroleum-contaminated soil. Strain YC-RL4 was identified as Mycobacterium sp. by 16S rRNA gene analysis and Biolog tests. Mycobacterium sp. YC-RL4 could rapidly degrade dibutyl phthalate (DBP), diethyl phthalate (DEP), dimethyl phthalate (DMP), dicyclohexyl phthalate (DCHP), and di-(2-ethylhexyl) phthalate (DEHP) under both individual and mixed conditions, and all the degradation rates were above 85.0 % within 5 days. The effects of environmental factors which might affect the degrading process were optimized as 30 °C and pH 8.0. The DEHP metabolites were detected by HPLC-MS and the degradation pathway was deduced tentatively. DEHP was transformed into phthalic acid (PA) via mono (2-ethylhexyl) phthalate (MEHP) and PA was further utilized for growth via benzoic acid (BA) degradation pathway. Cell surface hydrophobicity (CSH) assays illuminated that the strain YC-RL4 was of higher hydrophobicity while grown on DEHP and CSH increased with the higher DEHP concentration. The degradation rates of DEHP by strain YC-RL4 in different environmental samples was around 62.0 to 83.3 % and strain YC-RL4 survived well in the soil sample. These results suggested that the strain YC-RL4 could be used as a potential and efficient PAE degrader for the bioremediation of contaminated sites.

show abstract

Section: Responsible Editor: Gerald Thouandmentioning

confidence: 99%

Biodegradation of phthalic acid esters by a newly isolated Mycobacterium sp. YC-RL4 and the bioprocess with environmental samples

Ren

Yang

Nahurira

et al. 2016

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…In humans, phthalate exposure during pregnancy is associated with a number of infant and child developmental endpoints that are androgen mediated, including reduced anogenital distance (AGD) (22,23), a measure of fetal androgen exposure, and changes in sex-specific behavior (24,25). Few human studies have examined phthalate exposure and androgen concentrations during gestation; prenatal exposure to DEHP has been negatively associated with free testosterone (FT) and total testosterone (TT) concentrations in pregnancy and in umbilical cord blood (26,27). Unanswered questions remain, such as timing of exposure in relation to effects and the degree to which maternal sex steroid hormone concentration reflects that of the fetus.…”

mentioning

confidence: 99%

Early Prenatal Phthalate Exposure, Sex Steroid Hormones, and Birth Outcomes

Sathyanarayana

Butts

Wang

et al. 2017

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

Context: Adequate sex steroid hormone concentrations are essential for normal fetal genital development in early pregnancy. Our previous study demonstrated an inverse relationship between third-trimester di-2-ethyl hexyl phthalate exposure and total testosterone (TT) concentrations. Here, we examine earlypregnancy phthalates, sex steroid hormone concentrations, and newborn reproductive outcomes. Design:We examined associations between urinary phthalate metabolite concentrations in early pregnancy and serum free testosterone (FT), TT, estrone (E1), and estradiol (E2) in 591 woman/infant dyads in The Infant Development and Environment Study; we also examined relationships between hormones and newborn genital outcomes using multiple regression models with covariate adjustment.Results: E1 and E2 concentrations were 15% to 30% higher in relation to 1-unit increases in log monoisobutyl phthalate (MiBP), mono-2-ethyl hexyl phthalate, and mono-2-ethyl-5-oxy-hexyl phthalate concentrations, and E2 was 15% higher in relation to increased log monobenzyl phthalate (MBzP). FT concentrations were 12% lower in relation to 1-unit increases in log mono(carboxynonyl) phthalate (MCNP) and mono-2-ethyl-5-carboxypentyl phthalate concentrations. Higher maternal FT was associated with a 25% lower prevalence of having a male genital abnormality at birth. Conclusions:The positive relationships between MiBP, MBzP, and DEHP metabolites and E1/E2 are unique and suggest a positive estrogenic effect in early pregnancy. The inverse relationship between MCNP and DEHP metabolites and serum FT supports previous work examining phthalate/testosterone relationships later in pregnancy. Higher FT in relation to a 25% lower prevalence of male genital abnormalities confirms the importance of testosterone in early fetal development. Abbreviations: AGD, anogenital distance; AGD AC , anoclitoral distance; AGD AF , anofourchette distance; AGD AP , anopenile distance; AGD AS , anoscrotal distance; BBzP, benzyl butyl phthalate; CDC, Centers for Disease Control and Prevention; CI, confidence interval; DBP, dibutyl phthalate; DEHP, di-2-ethyl hexyl phthalate; EDC, endocrine-disrupting chemical; FT, free testosterone; HPLC, high-performance liquid chromatography; LC, liquid chromatography; LOD, limit of detection; MBP, monobutyl phthalate; MBzP, monobenzyl phthalate; MCNP, mono(carboxynonyl) phthalate; MCOP, mono(carboxy-isooctyl) phthalate; MECPP, mono-2-ethyl-5-carboxypentyl phthalate; MEHP, mono-2-ethylhexyl phthalate; MEHHP, mono-2-ethyl-5-hydroxy-hexyl phthalate; MEOHP, mono-2-ethyl-5-oxy-hexyl phthalate; MEP, monoethyl phthalate; MiBP, monoisobutyl phthalate; MS/MS, tandem mass spectrometry; SD, standard deviation; SHBG, sex hormone-binding globulin; TIDES, The Infant Development and the Environment Study; TT, total testosterone. 1870https://academic.oup.com/jcem

show abstract

“…This protocol was based on a protocol developed in our laboratory (Hsu et al, 2011;Lin et al, 2011). Urine (100 lL) was pipetted into 2-mL Eppendorf tubes, and then 25 lL of b-glucuronidase, 10 lL of sulphatase and 100 lL of a 1 lg/mL D 4 -MINP (internal standard) in 100% methanol were added to tube.…”

Section: Rat Urine Pretreatmentmentioning

confidence: 99%

“…Phthalates are endocrine disruptors and affect reproductive outcomes, the development of the male reproductive tract (Waterman et al, 1999;Gray et al, 2000;Kavlock et al, 2002), and sexual differentiation in male rats (Gray et al, 2000;Tyl et al, 2004;Foster, 2006). Epidemiological studies have also revealed that exposure to several commonly used phthalates can alter sex steroid hormone levels in human subjects (Main et al, 2006;Pan et al, 2006;Lin et al, 2011). Phthalates are easily released from plastic products because they are not chemically bonded to it.…”

Section: Introductionmentioning

confidence: 97%

“…Epidemiology studies have measured DINP metabolites in biofluids to prove ongoing exposure to DINP in general population and in special subpopulations, such as pregnant women and children . Human biomonitoring uses different matrices, such as blood, urine, and saliva, to measure DINP exposure (Niino et al, 2001;Frederiksen et al, 2010;Lin et al, 2011). Urine is the most common biofluid used for biological monitoring.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The potential use of diisononyl phthalate metabolites hair as biomarkers to assess long-term exposure demonstrated by a rat model

Hsu

Liao

2015

Chemosphere

Self Cite

View full text Add to dashboard Cite

Associations between maternal phthalate exposure and cord sex hormones in human infants

Cited by 117 publications

References 43 publications

Biodegradation of phthalic acid esters by a newly isolated Mycobacterium sp. YC-RL4 and the bioprocess with environmental samples

Biodegradation of phthalic acid esters by a newly isolated Mycobacterium sp. YC-RL4 and the bioprocess with environmental samples

Early Prenatal Phthalate Exposure, Sex Steroid Hormones, and Birth Outcomes

The potential use of diisononyl phthalate metabolites hair as biomarkers to assess long-term exposure demonstrated by a rat model

Contact Info

Product

Resources

About