Associations between nine candidate genetic polymorphisms with coronary heart disease

Li, Q.; Du, Qiang

doi:10.1007/s00059-019-4806-7

Cited by 6 publications

(3 citation statements)

References 57 publications

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“…Large-scale studies have documented that genetic polymorphisms are significantly associated with CHD at genome-wide significance [ 6 ]. Moreover, previous studies also have reported that a significant association between candidate gene polymorphism and CHD susceptibility [ 7 – 9 ]. These results underscored the crucial role of genetic factors in the pathogenesis of CHD.…”

Section: Introductionmentioning

confidence: 97%

Genetic variants in CYP11B1 influence the susceptibility to coronary heart disease

2022

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Background Genetic factors are important risk factors to develop coronary heart disease (CHD). In this study, we mainly explored whether CYP11B1 mutations influence CHD risk among Chinese Han population. Methods Six variants were genotyped using Agena MassARRAY system from 509 CHD patients and 509 healthy controls. The correlations between CYP11B1 mutations and CHD risk were assessed using odds ratio (OR) and 95% confidence interval (95% CI) by logistic regression. The haplotype analysis and were ultifactor dimensionality reduction (MDR) were conducted. Results In the overall analysis, CYP11B1 polymorphisms were not correlated with CHD susceptibility. In the stratified analysis, we found that rs5283, rs6410, and rs4534 are significantly associated with susceptibility to CHD dependent on age and gender (p < 0.05). Moreover, we also observed that rs5283 and rs4534 could affect diabetes/hypertension risk among CHD patients (p < 0.05). In addition, the Crs4736312Ars5017238Crs5301Grs5283Trs6410Crs4534 haplotype of CYP11B1 reduce the susceptibility to CHD (p < 0.05). Conclusions We found that rs4534, rs6410 and rs5283 in CYP11B1 gene influence the susceptibility to CHD, which depend on age and gender.

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Section: Introductionmentioning

confidence: 97%

Genetic variants in CYP11B1 influence the susceptibility to coronary heart disease

2022

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“…By far, more than 60 genetic variants have been identified to be related to an increased susceptibility to CHD in genome-wide association study (GWAS) analyses ( 4 ). Interestingly, studies have shown that single nucleotide polymorphisms (SNPs) can affect the level of gene production or the binding of targets, thus influencing the normal expression of genes and leading to the occurrence of diseases ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

Rs420137, rs386360 and rs7763726 polymorphisms in fibronectin type III domain containing 1 are associated with susceptibility to coronary heart disease: Analysis in the Han population

et al. 2022

Front. Cardiovasc. Med.

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BackgroundNumerous genetic studies have shown that genes are related to the pathogenesis of coronary heart disease (CHD). The main aim of this study was to confirm whether fibronectin type III domain containing 1 (FNDC1) polymorphisms correlate with the risk of CHD.MethodsIn this study, in order to assess the association between three FNDC1 single nucleotide polymorphisms (SNPs) and the risk of CHD, we conducted a case-control study involving 630 patients with CHD and 568 healthy controls using Agena MassARRAY (Agena Bioscience, San Diego, CA, USA). Genotype distribution in case and control groups was analyzed by Chi square test. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression models adjusted for age, sex, smoking, and alcohol consumption to assess the correlation between SNPs and CHD risk.ResultsOur results indicated that FNDC1-rs420137, -rs386360, and -rs7763726 played important roles in enhancing the risk of CHD. Subgroup analysis revealed that rs420137 increased the susceptibility to CHD in males, smokers, and patients aged ≤62 years. Rs360 had an increased risk of CHD in males, patients at aged ≤62 years, smokers, and non-drinkers. Furthermore, the association of rs7763726 with increased CHD risk was also observed in males, patients aged ≤62 years, smokers, and drinkers. Last but not least, these three SNPs we selected were protective factors against hypertension in CHD individuals.ConclusionOur research suggest that FNDC1-rs420137, -rs386360, and -rs7763726 variants may be regarded as novel biomarkers for predicting CHD risk and other specific mechanisms of action of CHD need to be further studied.

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“…В последнее время онкогематологи уделяют все больше внимания возможности раннего прогнозирования рисков развития кардиологических осложнений у пациентов вследствие лекарственной терапии за счет определения их генетических особенностей [9][10][11]. Актуальность проблемы подтверждается фактом включения в 2022 г. в рекомендации по кардиоонкологии Европейского общества кардиологов (European Society of Cardiology, ESC) генетического скрининга больных с онкогематологическими заболеваниями до начала лечения в целях оценки рисков развития кардиотоксичности.…”

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Molecular genetic markers of chemotherapy-induced cardiotoxicity in patients with oncohematological diseases (review)

Milyutkina,

Sustretov,

Limareva

2023

Usp. mol. onkol

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Cardiotoxicity of anticancer therapy is a severe adverse cardiovascular event affecting the survival of cancer patients. Modern methods for diagnosing cardiotoxicity allow to identify already occurred myocardial transformations, accompanied by symptoms of heart failure and are not predict and detect early changes in the heart tissue during treatment. Recently, increasing attention is paid to the search for molecular genetic markers, a single identification of which before starting treatment will make possible to determining the risks of cardiotoxicity and change treatment taking into account individual genetic characteristics. At the same time, most research on the effect of allelic variants of genes on cardio-vascular complications relate to chemotherapy of solid tumors. The review considered possible prognostic genetic variants of cardiotoxicity induced by chemotherapy in patients with the hematopoietic and lymphatic malignancies.

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Associations between nine candidate genetic polymorphisms with coronary heart disease

Cited by 6 publications

References 57 publications

Genetic variants in CYP11B1 influence the susceptibility to coronary heart disease

Genetic variants in CYP11B1 influence the susceptibility to coronary heart disease

Rs420137, rs386360 and rs7763726 polymorphisms in fibronectin type III domain containing 1 are associated with susceptibility to coronary heart disease: Analysis in the Han population

Molecular genetic markers of chemotherapy-induced cardiotoxicity in patients with oncohematological diseases (review)

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