Associations between obstructive sleep apnea and cardiac troponin T levels: a meta-analysis

Abstract

Objective: Cardiac troponin T (cTnT) is a sensitive indicator for heart damage and is an important clinical marker for acute myocardial infarction (MI). The recent development of a high-sensitivity cardiac troponin T (hs-cTnT) assay allows a more accurate diagnosis of C concentration. There appears to be an association between OSA and changes in serum cTnT levels. However, current research works in this area have reported mixed results. Therefore, this meta-analysis study was performed to evaluate the relationship between cTnT levels and OSA. Method:The Scopus, Embase, Web of Science, PubMed and Science Direct databases were searched without a lower time limit and until April 2020. In order to perform the meta-analysis, the heterogeneity of articles was examined using the I 2 test, and subsequently a random effects model was applied. Data analysis was performed using the Comprehensive Meta-Analysis software (version 2).Result: Six studies involving a total of 1,689 cases and 2,171 controls were included in this meta-analysis. The results of our study suggest that the aggregate odds ratio of hs-cTnT level in patients with OSA is 1.25 (95% confidence interval: 0.97-1.61). Conclusion:Our findings indicate that patients with OSA have 25% higher rate of hs-cTnT levels than people without OSA.