Associations between organophosphate esters concentrations and markers of liver function in US adolescents aged 12–19 years: A mixture analysis

Li, Ruiqiang; Zhan, Wenqiang; Ren, Jingyi; Xian, Gao; Huang, Xin; Ma, Yuxia

doi:10.1016/j.envpol.2022.120255

Cited by 17 publications

(4 citation statements)

References 62 publications

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“…A previous study indicated that the joint effects of several OPEs showed a positive relationship with ALP in US adolescents, which was consistent with the present result. However, a negative correlation was observed between the combined effects of multiple OPE exposure and ALT, and no significant association was observed with AST . Overall, these results suggest that exposure to OPEs might lead to liver dysfunction in organisms.…”

Section: Resultsmentioning

confidence: 63%

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Lipid Metabolic Disorders Induced by Organophosphate Esters in Silver Carp from the Middle Reaches of the Yangtze River

Liu,

Zhang,

et al. 2024

Environ. Sci. Technol.

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The Yangtze River fishery resources have declined strongly over the past few decades. One suspected reason for the decline in fishery productivity, including silver carp (Hypophthalmichthys molitrix), has been linked to organophosphate esters (OPEs) contaminant exposure. In this study, the adverse effect of OPEs on lipid metabolism in silver carp captured from the Yangtze River was examined, and our results indicated that muscle concentrations of the OPEs were positively associated with serum cholesterol and total lipid levels. In vivo laboratory results revealed that exposure to environmental concentrations of OPEs significantly increased the concentrations of triglyceride, cholesterol, and total lipid levels. Lipidome analysis further confirmed the lipid metabolism dysfunction induced by OPEs, and glycerophospholipids and sphingolipids were the most affected lipids. Hepatic transcriptomic analysis found that OPEs caused significant alterations in the transcription of genes involved in lipid metabolism. Pathways associated with lipid homeostasis, including the peroxisome proliferator-activated receptor (PPAR) signal pathway, cholesterol metabolism, fatty acid biosynthesis, and steroid biosynthesis, were significantly changed. Furthermore, the affinities of OPEs were different, but the 11 OPEs tested could bind with PPARγ, suggesting that OPEs could disrupt lipid metabolism by interacting with PPARγ. Overall, this study highlighted the harmful effects of OPEs on wild fish and provided mechanistic insights into OPE-induced metabolic disorders.

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Section: Resultsmentioning

confidence: 63%

“…However, a negative correlation was observed between the combined effects of multiple OPE exposure and ALT, and no significant association was observed with AST. 26 Overall, these results suggest that exposure to OPEs might lead to liver dysfunction in organisms.…”

Section: Associations Of σ 11 Ope Concentrations Withmentioning

confidence: 86%

Lipid Metabolic Disorders Induced by Organophosphate Esters in Silver Carp from the Middle Reaches of the Yangtze River

Liu,

Zhang,

et al. 2024

Environ. Sci. Technol.

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“…Covariates included age, sex, race, smoking status, drinking status, physical activity, education level, marital status, family poverty income ratio (PIR), and urinary creatinine, based on previous literature [29,30]. Additionally, independent risk factors identified from univariate linear analysis for BMI, TG, TC, HDL-c, and LDL-c were screened as the poten-tial covariates for the present research.…”

Section: Covariatesmentioning

confidence: 99%

Exposure to OPFRs Is Associated with Obesity and Dysregulated Serum Lipid Profiles: Data from 2017–2018 NHANES

Li,

Zhou

et al. 2024

Metabolites

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Widespread exposure to organophosphorus flame retardants (OPFRs) has been observed in the general population. Emerging studies have revealed OPFRs possess endocrine-disturbing properties. The present study aims to assess the association between urinary metabolites of OPFRs, BMI, and serum lipid profiles. Data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 were obtained, with 1334 adults enrolled in the current study. Urinary concentrations of bis (1-chloro-2-propyl) phosphate (BCIPP), bis(2-chloroethyl) phosphate (BCEP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), dibutyl phosphate (DBUP), and diphenyl phosphate (DPHP) were quantified to assess OPFR exposure. Covariate-adjusted linear and logistic regression models were conducted to explore the associations between log2-transformed concentrations of OPFR metabolites, BMI, obesity, and serum lipid profiles. Stratified analyses were performed to assess the heterogeneity of associations by age, gender, race, etc. Positive associations were found between OPFR exposure and the risk of obesity. The multivariate linear analysis indicated that a one-unit increase in log2-transformed urinary concentrations of BCEP and BDCPP was associated with 0.27 (95% CI: 0.02–0.52, p = 0.0338) and 0.56 (95% CI: 0.25–0.87, p = 0.0004) higher BMI value, respectively. One log2-unit increase in urinary BCEP and BDCPP concentrations was associated with 1.1-fold (95% CI: 1.02–1.18, p = 0.0096) and 1.19-fold (95% CI: 1.09–1.30, p = 0.0001) risk for developing obesity. Furthermore, the non-linear relationship between exposure to OPFRs and obesity was identified. Additionally, multivariable linear regression showed that urinary DPHP concentrations were inversely correlated with serum triglyceride (TG) levels (β = −7.41, 95% CI: −12.13 to −2.68, p = 0.0022). However, no other OPFR metabolites were found to be significantly statistically associated with serum lipid levels after adjusting for potential confounders. In conclusion, environmental exposure to OPFRs might contribute to obesity and dysregulated TG concentrations in adults. Future prospective research is warranted to confirm the causal relationship between metabolites of OPFRs and obesity.

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“…E-mail: Lucyqzhang@njmu.edu.cn. contributor to illness and death [1] . The liver, essential for metabolic balance, is crucial in metabolizing, distributing, and removing external substances.…”

Section: Introductionmentioning

confidence: 99%

Association of exposure to per- and polyfluoroalkyl substances with liver injury in American adults

Yan,

Zhang,

et al. 2024

J Biomed Res

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Epidemiological data is scarce regarding the association between exposure to mixtures of per-and polyfluoroalkyl substances (PFASs) and liver injury in the general populace. The current research used data from the National Health and Nutrition Examination Survey (2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018). The PFAS exposure levels were defined by the serum concentrations of PFASs with > 70% detection in samples, namely perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), perfluorodecanoic acid (PFDeA), and perfluorooctane sulfonic acid (PFOS). Liver injury was assessed from two aspects: first, the degree of liver inflammation was determined based on serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutamyltransferase (GGT), and total bilirubin (TBIL) levels; second, the degree of liver fibrosis was determined based on fibrosis-4 (FIB-4) index. We assessed the associations between individual or total PFAS exposure and these outcomes using multivariable linear regression models and logistic regression models, restricted cubic splines, and weighted quantile sum regression. Among the samples of 7484 American adults, the median concentration of PFOS was the highest, followed by PFOA and PFHxS. Using multivariable linear regression, a positive correlation was observed between all PFASs and liver enzymes such as ALT, AST, and TBIL. Additionally, the weighted quantile sum model indicated an overall positive association between the five PFASs and liver injury indicators. For liver function biomarkers and liver fibrosis, PFNA and PFOS were the most heavily weighting chemicals, respectively. Our findings provide new epidemiological evidence indicating a potential association between PFAS exposure and adverse effects on liver injury biomarkers, highlighting the potentially harmful effects of PFAS exposure on liver health.

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Associations between organophosphate esters concentrations and markers of liver function in US adolescents aged 12–19 years: A mixture analysis

Cited by 17 publications

References 62 publications

Lipid Metabolic Disorders Induced by Organophosphate Esters in Silver Carp from the Middle Reaches of the Yangtze River

Lipid Metabolic Disorders Induced by Organophosphate Esters in Silver Carp from the Middle Reaches of the Yangtze River

Exposure to OPFRs Is Associated with Obesity and Dysregulated Serum Lipid Profiles: Data from 2017–2018 NHANES

Association of exposure to per- and polyfluoroalkyl substances with liver injury in American adults

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