Associations between physical inactivity and dementia prevalence: ecological study using global data

Leisure‐time physical activity (LTPA) decreases the risk of dementia, whereas occupational physical activity (OPA) possibly increases the risk. Yet, previous findings are mixed. We therefore aimed to investigate the effect of LTPA and OPA, respectively, on dementia among men and women. In this observational, longitudinal study, we used data from the second wave of a population‐based cohort from the municipality of Copenhagen as baseline. Data were collected in 1981–1983, and 10 343 participants were followed until the end of 2016. LTPA and OPA were self‐reported, and information on dementia diagnoses and redemption of dementia medication was obtained at an individual level from national health registers. We used Poisson regression to analyze the association between LTPA/OPA and dementia and adjusted for self‐reported age, socioeconomic factors, stress, and cardiovascular risk factors (smoking, alcohol, body mass index, and blood pressure). A higher level of LTPA was associated with a lower dementia risk among men, but we found no clear association among women. OPA and dementia were not associated among men, but occupationally active women who reported OPA in terms of walking, lifting, and heavy work had a higher risk of dementia than women with sedentary jobs. This study supported earlier findings of a protective effect of LTPA on dementia among men. Women in physically demanding jobs possibly have a higher risk of dementia, yet this finding warrants further investigation in future studies.

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Cognitive decline is correlated with frailty in community-dwelling older adults

Chen,

Wu,

Lee

et al. 2024

Preprint

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Background Aging impacts both mental and physical health. The relationship between cognitive decline and frailty in aged individuals remains unclear. This study aimed to elucidate the correlation between cognitive and physical decline in elders, identify contributing factors, and explore potential blood biomarkers associated with these conditions. Methods Three groups at average aged of 65 (288 subjects), aged of 71 (196 subjects), and aged of 79 (80 subjects) were selected from the cohort of the Healthy Aging Longitudinal Study in Taiwan (HALST) database. Variables included global cognitive function, assessed by the Mini-Mental State Examination (MMSE), Fried frailty phenotype, and plasma tumor necrosis factor receptor-1 (TNFR1) were included. Statistical analyses utilized multiple regression analysis of variance, accounting for potential confounding variables. Results We found a gradual MMSE decline from average age of 65 to age of 79, which correlated with an increase in total frailty rating scores, especially in the components of exhaustion, slow walking speed, and weak grip strength (p ≦ 0.008). In addition, higher frailty scores were strongly associated with elevated plasma TNFR1 levels, particularly in components such as low physical activity, and weak grip strength (p ≦ 0.008). Conclusion Cognitive decline correlates with increase in frailty during aging process. Plasma TNFR1 emerges as a valuable indicator for identifying frailty in individuals.

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Associations between physical inactivity and dementia prevalence: ecological study using global data

Cited by 3 publications

References 19 publications

Exploring the global impact of obesity and diet on dementia burden: the role of national policies and sex differences

Exploring the global impact of obesity and diet on dementia burden: the role of national policies and sex differences

Effects of Occupational and Leisure‐Time Physical Activity on the Risk of Dementia: Results From the Copenhagen City Heart Study

Cognitive decline is correlated with frailty in community-dwelling older adults

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