Associations Between Plasma C-reactive Protein Levels and the Severities of Coronary and Aortic Atherosclerosis

Momiyama, Yukihiko; Ohmori, Reiko; Fayad, Zahi A.; Kihara, Teruyoshi; Tanaka, Norihiro; Kato, Ryuichi; Taniguchi, Hiroaki; Nagata, Masayoshi; Nakamura, Haruo; Ohsuzu, Fumitaka

doi:10.5551/jat.2931

Cited by 28 publications

(22 citation statements)

References 36 publications

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“…Acute reactant hsCRP, an important marker of inflammation, appears to stimulate endothelial dysfunction and promote inflammation in the vessel wall, thus contributing to the initiation and progression of atherogenesis 13,14) and an increased risk of cardiovascular events 15,16) . Several prospective epidemiologic and randomized controlled studies of statin therapy have shown that the hsCRP level is either an independent predictor of future cardiovascular risk 7,[17][18][19] or provides additive value, together with other traditional risk factors, for predicting cardiovascular events 20,21) .…”

Section: Discussionmentioning

confidence: 99%

Correlations Between the Level of High-Sensitivity C-Reactive Protein and Cardiovascular Risk Factors in Korean Adults with Cardiovascular Disease or Diabetes Mellitus: The CALLISTO Study

Seo

Baek

Jeon

et al. 2013

JAT

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Aim:We assessed the relationship between the level of high-sensitivity C-reactive protein (hsCRP) and cardiovascular risk factors in Korean adults. Methods: We reviewed 1,561 patients with cardiovascular disease or diabetes mellitus with hsCRP levels measured within the past year. Four cardiovascular risk groups were determined: low (＜10%, 0-1 risk), moderate (＜10%, ＞2 risk), high (10-20%) and very high (＞20%) risk, according to the number of risk factors and the Framingham/NCEP ATP Ⅲ risk score. The correlations between the hsCRP level and cardiovascular risk factors (age, smoking, hypertension, lipid profiles and familial history of premature coronary heart disease) were investigated. Results: The mean and median hsCRP (mg/L) levels were 1.32±9.69 and 0.29 (range: 0.01-7.48), respectively. Men had a higher median level of hsCRP than women (p＜0.001). The levels of hs CRP significantly increased from the low to the very high risk group (0.15, 0.23, 0.27 and 0.47, respectively) and were significantly correlated with age, the level of glycosylated hemoglobin, body mass index (BMI), the level of high-density lipoprotein cholesterol (HDL-C), the low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, the LDL-C/total cholesterol (TC) ratio, the HDL-C/TC ratio, the HDL-C/triglyceride (TG) ratio and the TC/TG ratio. Neither smoking, the LDL-C level nor the TG level affected the hsCRP level. In a multivariate regression analysis, age, the HDL-C level, the LDL-C/TC ratio and BMI were found to be independently correlated with the hsCRP level. Conclusions: There is a significant relationship between the degree of cardiovascular risk and the hsCRP level in Korean adults with cardiovascular disease or diabetes mellitus. Assessing the hsCRP levels may thus provide additive value in predicting cardiovascular risks.J Atheroscler Thromb, 2013; 20:616-622.

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Section: Discussionmentioning

confidence: 99%

Correlations Between the Level of High-Sensitivity C-Reactive Protein and Cardiovascular Risk Factors in Korean Adults with Cardiovascular Disease or Diabetes Mellitus: The CALLISTO Study

Seo

Baek

Jeon

et al. 2013

JAT

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“…The CRP concentration was higher in patients with this angiographic degree of stenosis, showing that CRP concentration was correlated with degree of disease severity in patients with CHD. Momiyama et al, (21) Piranfar, (22) Masood et al, (23) and Lai et al, (24) arrived at similar conclusions, namely that CRP is an index of CHD severity and may reflect plaque activity in patients with CHD, and is therefore important for clinical diagnosis and evaluation CHD risk. (21)(22)(23)(24) Another study by Ciccone et al (25) found that thickening of the carotid intima media was correlated with CRP, thus indicating that inflammatory markers affect the progressivity of atherosclerosis in subjects with obstructive sleep apnea.…”

Section: Discussionmentioning

confidence: 76%

“…(21) Determination of blood viscosity was by means of an Ostwald viscometer, in which the blood sample in the Ostwald tube descends by gravitation. The time of descent was recorded with a stopwatch.…”

Section: Laboratory Analysismentioning

confidence: 99%

Blood viscosity increases the degree of coronary stenosis in coronary heart disease

Indrianto

Samsuria

Kurniawan

2016

UnivMed

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BACKGROUNDEndothelial dysfunction and associated increased blood viscosity (BV) play an important role in the formation of atherosclerosis during inflammatory processes. C-reactive protein (CRP) is a biomarker of inflammation with an active role in endothelial dysfunction and development of atherosclerosis that is marked by degree of coronary stenosis (CS). The purpose of this study was to determine the relationship of BV and CRP with varying degrees of CS among coronary heart disease (CHD) patients. METHODSThis cross-sectional study involved 24 subjects taken consecutively among patients with CHD who underwent angiography. Blood viscosity levels were determined using an Ostwald viscometer, with reference limits of 1.5 to 1.72 (cP). C-reactive protein was determined by turbidimetric immunoassay, with a normal reference value of <3 mg/L. Degree of CS was examined with angiography, where 0% = no stenosis; <50% = nonsignificant stenosis; > 50% = significant stenosis. Data was analyzed using non-parametric Spearman correlation test. RESULTSThere were 17 male and 7 female subjects, with mean age of 55.96 ± 7.29 years. The angiography results were: non-significant stenosis in 2 subjects (8.3%), significant stenosis in 22 subjects (91.7%) and none with normal stenosis. Statistical analysis of the relationship of BV with degree of CS found a moderate significant positive relationship (r=0.549; p=0.005). A poor significant positive relationship was found between CRP and degree of CS (r=0.481; p=0.017). CONCLUSIONBlood viscosity increased the degree of CS in CHD patients. Therapy should target both BV-associated risk and angiographically evident stenosis. Keywords

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“…Известно, что СРБ является одним из основных маркеров хронического вос-паления и непосредственно участвует в про-грессировании атеросклероза КА [18]. В одном из исследований выявлено, что висцеральная жировая ткань (ВЖТ) стимулирует синтез СРБ [19].…”

Section: таблицаunclassified

Predictors of Coronary Atherosclerosis at Men With the Metabolic Syndrome

Рудакова¹,

Веселовская²,

Чумакова³

et al. 2017

Kompleks. probl. serdečno-sosud. zabol.

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Цель. Изучить совокупность факторов риска (ФР), наиболее значимо связанных с риском коронарного атеросклероза у мужчин с метаболическим синдромом (МС).Материалы и методы. В исследование было включено 82 мужчины с МС по критериям ВНОК, 2009 г., в воз-расте 39-73 лет (56,42±7,3 лет). Группу 1 (n=40) составили пациенты с МС и ИБС -стенокардией напряжения II-III ф кл. и коронарным атеросклерозом по данным коронароангиографии; группу 2 (n=42) -пациенты с МС, не имеющие ИБС -стенокардии напряжения и признаков коронарного атеросклероза. В группах сравнения был проведен анализ основных и дополнительных метаболических ФР и с помощью метода логистической регрессии поиск наиболее неблагоприятной совокупности ФР, связанных с коронарным атеросклерозом у пациентов с МС. Результаты. У пациентов группы 1 (n=40) были определены более высокие показатели инсулина (р<0,001), индекса HOMA-IR (р<0,001), Апо В (р<0,05), ЛПа (р<0,05), ИЛ-6 (р<0,05), ФНО-α (р<0,05), вчСРБ (р<0,05) и более низкие показатели Апо А1 (р<0,05), апелина (р<0,001), чем в группе 2 (n=42). Наиболее неблагоприятной совокупностью ФР, связанных с коронарным атеросклерозом у пациентов с МС, стали по-казатели, характеризующие нейрогуморальную активность висцеральной жировой ткани (ВЖТ) (апелин), показатель липидного спектра крови (АпоВ), показатель углеводного обмена (инсулин), показатели провос-палительной активности плазмы (ИЛ-6, вчСРБ) и показатель абдоминального ожирения (ОТ).Заключение. Полученная совокупность предикторов позволяет выбрать более перспективные и рацио-нальные схемы медикаментозной и немедикаментозной профилактики сердечно-сосудистых осложнений у пациентов с МС. Полученные данные являются также ценным материалом для проведения дальнейших научных исследований с изучением роли нейрогуморальной и провоспалительной активности ВЖТ в риске развития ИБС у пациентов с МС.Ключевые слова: метаболический синдром, коронарный атеросклероз, факторы риска. The purpose. Тo study set of the risk factors (RF) which are most significantly connected with risk of coronary atherosclerosis at men with the metabolic syndrome (MS). PREDICTORS OF CORONARY ATHEROSCLEROSIS AT MEN WITH THE METABOLIC SYNDROMEMaterial and methods. The research included 82 men from MS by criteria of ВНОК, 2009, at the age of 39 -73 years (56,42±7,3 years). Group 1 (n=40), patients with MS and a coronary heart disease: angina of pectoralis of II-III f.cl. and a coronary atherosclerosis according to a coronaroangiography, group 2 (n=42), patients about the MS which don't have a coronary heart disease: angina of pectoralis and symptoms of coronary atherosclerosis. In groups of comparison the analysis of the main and additional metabolic RF and by means of a method of logistic regression search of the most adverse set of RF bound to a coronary atherosclerosis at patients with MS was carried out.Results. At patients of group 1 (n=40) higher rates of insulin (р<0,001), HOMA-IR index (р<0,001), Apo B (р<0,05), LPa (р<0,05), IL-6 (р<0,05), ФНО-α (р<0,05), CRP (р<0,05) and lower indicators of ApoA1 (р<0,...

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Associations Between Plasma C-reactive Protein Levels and the Severities of Coronary and Aortic Atherosclerosis

Cited by 28 publications

References 36 publications

Correlations Between the Level of High-Sensitivity C-Reactive Protein and Cardiovascular Risk Factors in Korean Adults with Cardiovascular Disease or Diabetes Mellitus: The CALLISTO Study

Correlations Between the Level of High-Sensitivity C-Reactive Protein and Cardiovascular Risk Factors in Korean Adults with Cardiovascular Disease or Diabetes Mellitus: The CALLISTO Study

Blood viscosity increases the degree of coronary stenosis in coronary heart disease

Predictors of Coronary Atherosclerosis at Men With the Metabolic Syndrome

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