2021
DOI: 10.1186/s12940-021-00778-z
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Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco

Abstract: Background Environmental chemical exposures can affect telomere length, which in turn has been associated with adverse health outcomes including cancer. Firefighters are occupationally exposed to many hazardous chemicals and have higher rates of certain cancers. As a potential biomarker of effect, we assessed associations between chemical exposures and telomere length in women firefighters and office workers from San Francisco, CA. Methods We measu… Show more

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Cited by 21 publications
(9 citation statements)
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“…( Eick et al, 2020 ). We focused our analysis on those PFAS with ≥ 70% detection in the combined cohort ( Clarity et al, 2021 ; Trowbridge et al, 2020 ), which included PFOA, PFOS, PFNA, PFHxS, PFDeA, PFUdA, and Me-PFOSA-AcOH. MDL values are provided in Table S1 .…”
Section: Methodsmentioning
confidence: 99%
“…( Eick et al, 2020 ). We focused our analysis on those PFAS with ≥ 70% detection in the combined cohort ( Clarity et al, 2021 ; Trowbridge et al, 2020 ), which included PFOA, PFOS, PFNA, PFHxS, PFDeA, PFUdA, and Me-PFOSA-AcOH. MDL values are provided in Table S1 .…”
Section: Methodsmentioning
confidence: 99%
“…Through the Women Firefighters Biomonitoring Collaborative, Trowbridge and colleagues [17] measured serum concentrations of PFAS in women firefighters compared to office workers and found firefighters had higher mean concentrations of PFAS. Clarity and colleagues [18] measured serum concentrations of PFAS and found significant associations between perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS; both kinds of PFAS) and telomere length. Telomere length is associated with fertility (longer telomeres indicating fertility).…”
Section: Resultsmentioning
confidence: 99%
“…There is a critical need to further study the relationship between firefighter exposure and women's health; it is apparent that the reproductive health of women firefighters in relation to their occupational exposures need to be examined. Furthermore, it is clear that women firefighters are understudied; in our review of the literature, only 12 studies focused on women firefighters and cancer 9–20 …”
Section: Discussionmentioning
confidence: 99%
“…In addition, an increased incidence of melanoma was identified in Australian women volunteer firefighters 13 . There is a dearth of literature focusing on cancer among women firefighters, including projects focusing on overall well-being, exposures, and cancer mortality rates 9–20 …”
Section: Manuscript Textmentioning
confidence: 99%