Associations between polymorphisms of long non-coding RNA MEG3 and risk of colorectal cancer in Chinese

Abstract

Maternally expressed gene 3 (MEG3), a long non-coding RNA (lncRNA), is involved in cancer development and metastasis. The objective of the present study was to evaluate whether common single nucleotide polymorphisms (SNPs) in MEG3 could be related with colorectal cancer risk in Chinese. We genotyped six tagSNPs of MEG3 in a colorectal cancer case-control study including 518 cases and 527 control subjects. Multivariate logistic regression analysis was applied to calculate adjusted odds ratios (ORs). We found that MEG3 rs7158663 AA genotype, but not GA genotype, had significant increased colorectal cancer risk, compared with GG genotype (OR = 1.96 and P = 0.006 for AA versus GG, and OR = 1.20 and P = 0.171 for GA versus GG). Further stratified analysis indicated that the increased risk was significantly correlated with individuals with age ≤ 60 and family history of cancer. However, there was no significant association between rs7158663 and colorectal tumor site and stage (P = 0.842 for tumor site, and P = 0.601 for tumor stage). These results demonstrate that genetic variants in MEG3 may contribute to the development and risk of colorectal cancer. Further studies are required to confirm these findings.

Retracted: Knockdown of lncRNA MEG3 inhibits viability, migration, and invasion and promotes apoptosis by sponging miR‐127 in osteosarcoma cell

“…Similarly, Zhang et al demonstrated that increased expression of SPRY4‐IT1 in clear cell renal cell carcinoma led to poor prognosis, and vice versa. Aberrant expression of lncRNA maternally expressed gene 3 (MEG3) in several cancers especially in gastric, colorectal, ovarian, cervical cancers, and OS have been reported recently . However, the precise molecular mechanism(s) behind the altered expression of MEG3 in OS and its function are still unclear.…”

Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis

“…Moreover, the SNPs in MEG3 also participate in the development of different types of cancer. For example, Cao et al discovered that rs7158663 in MEG3 had a strong association with an increased risk of CRC [29]. Studies also demonstrated that rs4081134 in MEG3 was associated with lung cancer susceptibility in a hospital-based case-control study [30].…”

“…Moreover, Zheng et al [21] investigated rs145204276 in two independent stages, so we treated the study as two independent investigations. Four articles considered not only rs7158663 but also rs4081134 in lncRNA MEG3 [29][30][31][32]. Two articles involved rs1902432, rs16901904, rs4871771, and rs710886 in lncRNA PCAT-1 [27,28].…”

“…In contrast, there was no association between lncRNA PCAT-1 rs1902432 and bladder cancer in the two-stage, case-control study conducted by Lin et al [27]. Similarly, the published results on the relation between lncRNA maternally expressed gene 3 (lncRNA MEG3) polymorphisms and cancer risk were also diverse [29][30][31][32]. Therefore, we conducted a meta-analysis in order to summarize all eligible studies and evaluate the overall relation between cancer risk and lncRNA (GAS5, PCAT-1, and MEG3) polymorphisms.…”

Association of long non‐coding RNA MEG3 polymorphisms with oral squamous cell carcinoma risk

“…However, the association between rs11160608 with colorectal cancer risk was not detected in this study. Furthermore, Zhou et al reported no association between rs7158663 and rs4081134 with neuroblastoma risk (Cao et al, ). In our study, this is the first time to invest the relationship between SNPs in MEG3 and OSCC risk in China.…”