Associations between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity

Hengartner, Tobias; Adams, Mark; Pfister, Riccardo; Snyers, Diane; McDougall, Jane; Held-Egli, Katrin; Spring, Lea; Rogdo, Bjarte; Riedel, Thomas; Mieth, Romaine Arlettaz

doi:10.1159/000512020

Cited by 25 publications

(30 citation statements)

References 25 publications

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“…The number of subjects with ROP are equally divided within the birth weight category with 11 subjects weighing < 1500 g and 11 subjects weighing ≥ 1500 g. Most of the patients with ROP were on oxygen therapy for ≥ 7 days, similar to the findings of a study conducted in Jakarta (18), but opposing to a report by Hakeem et al (19) Out of 22 patients with ROP, only 5 received RBC transfusion. This result is in line with a study by Rao et al (20) and opposite of a report by Hengartner et al (21) Almost all of the patients with ROP were born by caesarean section and only one patient was born spontaneously. This result is in accordance with a research by Dewi et al (22) Most of the case group subjects were born single, similar to the findings of previous studies (13,23) and in contrast with a study by Akkawi et al (24) Preterm birth is defined as a live birth before the gestational age reaches a full 37 weeks.…”

Section: Discussionsupporting

confidence: 90%

“…Infants who received RBC transfusion have 1.09 times (95% CI 0.343-3.480) higher odds for the occurrence of ROP compared to those who never received red blood cell transfusion. Badriah et al (18) and Hengartner et al (21) who previously conducted a study in Indonesia and Switzerland respectively reported similar findings where RBC transfusion is not related to the development of ROP (p=0.327, p=0.179). In contrast, two previous studies reported significant relation between red blood cell transfusion and retinopathy of prematurity.…”

Section: Discussionmentioning

confidence: 60%

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Risk Factors of Retinopathy of Prematurity in Tertiary Hospital

Raniasari¹,

Prastyani²,

Etika³

et al. 2021

IJRP

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Introduction: Retinopathy of prematurity is a potentially blinding disease of the eye due to abnormal retinal vascularization. Gestational age, preterm birth, oxygen therapy, and RBC transfusion are some of the factors associated with ROP. Purpose: This study aims to determine the relation between gestational age, birth weight, duration of oxygen therapy, and RBC transfusion with ROP. Methods: This research is a case-control study using medical records data from Dr. Soetomo General Hospital in the period of January -June 2019. Data is analyzed using logistic regression analysis in SPSS v. 25. Results: The case group consists of 22 patients with ROP while the control group consists of 66 patients without ROP. Gestational age (p=0.030; OR=3.10, 95% CI 1.113-8.606) and duration of oxygen therapy (p=0.012; OR=3.75, 95% CI 1.342-10.481) shows a statistically significant relation with ROP. There is no relation between birth weight (p=0.098; OR= 2.30, 95% CI 0.857-6.171) and RBC transfusion (p=0.881; OR=1.09; 95% CI 0.343-3.480) with ROP. Conclusions: There is a relation between gestational age and duration of oxygen therapy with ROP. Meanwhile, birth weight and RBC transfusion have no relation with ROP.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 60%

Risk Factors of Retinopathy of Prematurity in Tertiary Hospital

Raniasari¹,

Prastyani²,

Etika³

et al. 2021

IJRP

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“…The primary outcome was a composite of death, BPD, NEC, or ROP. This composite outcome was selected on the basis of the importance of these outcomes to the risk of long-term neurodevelopmental impairment, 22 , 23 the role of oxidant stress and/or inflammation in the pathogenesis of these diseases, 24 and prior studies 10 , 25 , 26 , 27 reporting potential associations between RBC transfusion and an increased risk of components of the composite outcome. In addition, a similar composite outcome was used in a prior trial comparing neonatal transfusion thresholds.…”

Section: Methodsmentioning

confidence: 99%

Association of Blood Donor Sex and Age With Outcomes in Very Low-Birth-Weight Infants Receiving Blood Transfusion

et al. 2021

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IMPORTANCE There are conflicting data on the association between blood donor characteristics and outcomes among patients receiving transfusions.OBJECTIVE To evaluate the association of blood donor sex and age with mortality or serious morbidity in very low-birth-weight (VLBW) infants receiving blood transfusions. DESIGN, SETTING, AND PARTICIPANTSThis is a cohort study using data collected from 3 hospitals in Atlanta, Georgia. VLBW infants (Յ1500 g) who received red blood cell (RBC) transfusion from exclusively male or female donors were enrolled from January 2010 to February 2014. Infants received follow-up until 90 days, hospital discharge, transfer to a non-study-affiliated hospital, or death. Data analysis was performed from July 2019 to December 2020.EXPOSURES Donor sex and mean donor age. MAIN OUTCOMES AND MEASURESThe primary outcome was a composite outcome of death, necrotizing enterocolitis (Bell stage II or higher), retinopathy of prematurity (stage III or higher), or moderate-to-severe bronchopulmonary dysplasia. Modified Poisson regression, with consideration of covariate interactions, was used to estimate the association between donor sex and age with the primary outcome, with adjustment for the total number of transfusions and birth weight. RESULTSIn total, 181 infants were evaluated, with a mean (SD) birth weight of 919 (253) g and mean (SD) gestational age of 27.0 (2.2) weeks; 56 infants (31%) received RBC transfusion from exclusively female donors. The mean (SD) donor age was 46.6 (13.7) years. The primary outcome incidence was 21% (12 of 56 infants) among infants receiving RBCs from exclusively female donors, compared with 45% (56 of 125 infants) among those receiving RBCs from exclusively male donors. Significant interactions were detected between female donor and donor age (P for interaction = .005) and between female donor and number of transfusions (P for interaction < .001). For the typical infant, who received a median (interquartile range) of 2 (1-3) transfusions, RBC transfusion from exclusively female donors, compared with male donors, was associated with a lower risk of the primary outcome (relative risk, 0.29; 95% CI, 0.16-0.54). The protective association between RBC transfusions from female donors, compared with male donors, and the primary outcome increased as the donor age increased, but decreased as the number of transfusions increased. CONCLUSIONS AND RELEVANCEThese findings suggest that RBC transfusion from female donors, particularly older female donors, is associated with a lower risk of death or serious morbidity in VLBW infants receiving transfusion. Larger studies confirming these findings and examining potential mechanisms are warranted.

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“…During the development of ROP, the expression of hypoxia-related factors increases abnormally. 21 , 22 Studies with OIR mice have indicated that during retinal angiogenesis, hypoxia causes cells to undergo oxidative stress, leading to cell apoptosis, which affects inflammation and leads to pathological changes in the retinal blood vessels. 23 – 26 The lncRNA TUG1 is widely expressed in normal mammalian tissues.…”

Section: Discussionmentioning

confidence: 99%

The Long-Noncoding RNA TUG1 Regulates Oxygen-Induced Retinal Neovascularization in Mice via MiR-299

Wang

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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Purpose The oxygen-induced retinal neovascularization mouse model closely approximates pathological changes associated with human retinal neovascularization-associated diseases, including retinopathies. We used this model and human retinal endothelial cells (HRECs) under hypoxia to explore the relationship between taurine upregulated gene-1 (TUG1), vascular endothelial growth factor (VEGF), and miR-299-3p on retinopathy of prematurity (ROP). Methods An oxygen-induced retinopathy (OIR) mouse model was established; the mice were divided into a normal control group, OIR group, TUG1 control group (lentivirus control), and TUG1-knockdown group. The apoptosis of retinal cells was evaluated using a TUNEL assay. Angiogenic, apoptotic, and inflammatory factors were detected by Western blot, immunohistochemistry, and immunofluorescence analyses. HRECs were cultured under hypoxia and assessed for VEGF expression, apoptosis, tubule formation, and migration ability. The relationship between TUG1, VEGF, and miR-299-3p was detected via a dual luciferase reporter gene assay. Results Intravitreal injection of TUG1 lentivirus reduced the inflammatory response in the mouse retinal tissue and markedly reduced pathological changes in the retina. Overexpression of miR-299 in HRECs reduced the apoptosis rate, tube formation, and migration ability of hypoxia-treated cells, thereby inhibiting the formation of new blood vessels. The dual luciferase reporter gene assay suggested that miR-299 has binding sites for TUG1 and VEGF. Conclusions TUG1 reduces the expression of VEGFA by competitively adsorbing miR-299-3p and facilitates the regulation of retinal neovascularization, suggesting that it may serve as a new therapeutic target for retinal neovascular diseases.

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Associations between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity

Cited by 25 publications

References 25 publications

Risk Factors of Retinopathy of Prematurity in Tertiary Hospital

Risk Factors of Retinopathy of Prematurity in Tertiary Hospital

Association of Blood Donor Sex and Age With Outcomes in Very Low-Birth-Weight Infants Receiving Blood Transfusion

The Long-Noncoding RNA TUG1 Regulates Oxygen-Induced Retinal Neovascularization in Mice via MiR-299

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