Associations between sensitisation to allergens and allergic diseases: a hospital-based case–control study in China

Zhang, Wei; Xie, Biao; Liu, Meina; Wang, Yupeng

doi:10.1136/bmjopen-2021-050047

Cited by 2 publications

(2 citation statements)

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“…Overall, A + AR is associated with polysensitization in Europe, [73][74][75][76][77][78][79][80] New Zealand, 81 Brazil, 82 and China. 83,84 Patients monosensitized to cat or dog showed IgE patterns dominated by Fel d 1 (>90%) or Can f 5 (67%). [85][86][87] By…”

Section: Rhinitis and Asthma Phenotypes In Adolescents And Adultsmentioning

confidence: 99%

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Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

Bousquet

Melén

Haahtela

et al. 2023

Allergy

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Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper-and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper-and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.

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Section: Rhinitis and Asthma Phenotypes In Adolescents And Adultsmentioning

confidence: 99%

“…These findings were reproduced in BAMSE (Barn/Children, Allergy/Asthma, Milieu, Stockholm). Overall, A + AR is associated with polysensitization in Europe, 73–80 New Zealand, 81 Brazil, 82 and China 83,84 …”

Section: Canonical Epidemiology Confirming Mhealth Datamentioning

confidence: 99%

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

Bousquet

Melén

Haahtela

et al. 2023

Allergy

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Exposure to air pollution concentrations of various intensities in early life and allergic sensitisation later in childhood

Ziou

Cao

Wheeler

et al. 2023

Preprint

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BACKGROUND Evidence on the relationship between air pollution and allergic sensitisation in childhood is inconsistent, and this relationship has not been investigated in the context of smoke events that are predicted to increase with climate change. Thus, we aimed to evaluate associations between exposure in two early life periods to severe levels of particulate matter with an aerodynamic diameter < 2.5µm (PM2.5) from a mine fire, background PM2.5, and allergic sensitisation later in childhood. METHODS We measured specific immunoglobulin E (IgE) levels for seven common aeroallergens as well as total IgE levels in a cohort of children who had been exposed to the Hazelwood coal mine fire, either in utero or during their first two years of life, in a regional area of Australia where ambient levels of PM2.5 are generally low. We estimated personal exposure to fire-specific emissions of PM2.5 based on a high-resolution meteorological and pollutant dispersion model and detailed reported movements of pregnant mothers and young children during the fire. We also estimated the usual background exposure to PM2.5 at the residential address at birth using a national satellite-based land-use regression model. Associations between both sources of PM2.5 and sensitisation to dust, cat, fungi, and grass seven years after the fire were estimated with logistic regression, while associations with total IgE levels were estimated with linear regression. RESULTS No association was found between the levels of exposure at either developmental stage to fire-related PM2.5 and allergic sensitisation seven years after the event. However, levels of background exposure were positively associated with sensitisation to dust (OR = 1.89, 95%CI = 1.11,3.20 per 1 µg/m3). CONCLUSIONS Chronic but low exposure to PM2.5 in early life could be more strongly associated with allergic sensitisation in childhood than time-limited high exposure levels, such as the ones experienced during landscape fires.

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Associations between sensitisation to allergens and allergic diseases: a hospital-based case–control study in China

Cited by 2 publications

References 50 publications

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

Exposure to air pollution concentrations of various intensities in early life and allergic sensitisation later in childhood

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