Associations between serum bilirubin levels and essential trace elements status in an adult population

Peng, You‐Fan; Wei, Ye‐Sheng

doi:10.18632/oncotarget.18351

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…In addition to the increased utilization of UA and tBILI as radical scavengers, other factors related to serum iron could also influence their levels. Serum iron was found to be independently correlated with bilirubin, and inflammation has been proposed as the basis for this relationship (28). This could be relevant to the low tBILI observed in diabetic subjects with low serum iron levels in our study, considering that T2DM is an inflammatory state (7).…”

Section: Discussionsupporting

confidence: 63%

Serum redox markers in uncomplicated type 2 diabetes mellitus accompanied with abnormal iron levels

Angelovski,

Spirovska,

Nikodinovski

et al. 2023

Cent Eur J Public Health

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Objectives: This study aimed at evaluating the serum redox status in type 2 diabetes mellitus (T2DM) accompanied with an imbalance in iron concentrations.Methods: Diabetic patients were grouped according to serum iron levels [normal (DNFe), low (DLFe), and high (DHFe)], and their clinical and redox parameters [total sulfhydryl groups (tSH), uric acid (UA), and total bilirubin (tBILI) as non-enzymatic antioxidants, and malondialdehyde (MDA) and advanced oxidation products of proteins (AOPP) as markers of oxidative stress] were determined.Results: Glucose and HbA1c levels in the T2DM patients did not differ in function of serum iron. T2DM was associated with reduced tSH levels. In the diabetic patients, tSH, UA, and tBILI negatively correlated with MDA, as well as HbA1c with UA. Accordingly, AOPP and MDA were higher in the diabetic groups compared to the controls. The reduced antioxidant capacity was particularly pronounced in the DLFe group, which was further characterized by lower levels of UA and tBILI compared to the other groups. Subsequently, the level of MDA in the DLFe group was higher compared to the DNFe and DHFe groups. The positive correlation between serum iron levels and the antioxidants UA and tBILI, in conjunction with the negative correlation between serum iron levels and the markers of oxidative stress in the diabetic patients, corroborated the indication that comparatively higher level of oxidative stress is present when T2DM coexists with decreased iron levels.Conclusions: T2DM-associated redox imbalance is characterized by a decrease in serum total sulfhydryl groups and low serum iron-associated reduction in uric acid and total bilirubin levels, accompanied by increased oxidative stress markers. The relatively noninvasive and simple determination of these parameters may be of considerable interest in monitoring the pathophysiological processes in T2DM patients, and may provide useful insights into the effects of potential therapeutic or nutritional interventions.

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Section: Discussionsupporting

confidence: 63%

Serum redox markers in uncomplicated type 2 diabetes mellitus accompanied with abnormal iron levels

Angelovski,

Spirovska,

Nikodinovski

et al. 2023

Cent Eur J Public Health

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“…Choi et al (2018) [80] summarized the evidence supporting the association between zinc deficiency and CVD development, underscoring the potential diagnostic and prognostic implications of zinc homeostasis-associated molecules in CVD. Peng & Wei (2017) [81] found that low serum zinc concentrations and high serum copper concentrations were linked to inflammatory factors in patients with CVD.…”

Section: Importance Of Zinc (Zn)mentioning

confidence: 99%

How Do Minerals, Vitamins, and Intestinal Microbiota Affect the Development and Progression of Heart Disease in Adult and Pediatric Patients?

et al. 2023

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Cardiovascular diseases (CVDs) are the leading cause of death worldwide, far ahead of cancer. Epidemiological data emphasize the participation of many risk factors that increase the incidence of CVDs, including genetic factors, age, and sex, but also lifestyle, mainly nutritional irregularities and, connected with them, overweight and obesity, as well as metabolic diseases. Despite the importance of cardiovascular problems in the whole society, the principles of prevention of CVDs are not widely disseminated, especially among the youngest. As a result, nutritional neglect, growing from childhood and adolescence, translates into the occurrence of numerous disease entities, including CVDs, in adult life. This review aimed to draw attention to the role of selected minerals and vitamins in health and the development and progression of CVDs in adults and children. Particular attention was paid to the effects of deficiency and toxicity of the analyzed compounds in the context of the cardiovascular system and to the role of intestinal microorganisms, which by interacting with nutrients, may contribute to the development of cardiovascular disorders. We hope this article will draw the attention of society and the medical community to emphasize promoting healthy eating and proper eating habits in children and adults, translating into increased awareness and a reduced risk of CVD.

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“…Both animal-derived bilirubin, such as that from cow bezoar, and plant-derived bilirubin analogs, like phycocyanin, have been shown to exert beneficial effects on human health [ 13 – 15 ]. Moreover, taking iron and zinc supplements or adjusting dietary strategies can gently increase bilirubin concentration [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Positive association between serum bilirubin within the physiological range and serum testosterone levels

Ling,

Liu,

Yao

et al. 2024

BMC Endocr Disord

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Backgrounds Research has demonstrated that elevated serum total bilirubin (STB) levels have a beneficial impact on various diseases, particularly metabolic syndrome. This study aims to investigate the association between STB levels and serum testosterone (STT) in order to determine if bilirubin plays a protective role in relation to testosterone deficiency (TD) risk. Methods In this study, a total of 6,526 eligible male participants aged 20 years or older were analyzed, all of whom took part in the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2016. To investigate the relationship between STB and STT levels, we employed weighted multivariate regression models along with restricted cubic splines (RCS). Additionally, a subgroup analysis was conducted to explore the heterogeneity of this relationship across different subpopulations. Results Among the participants, 1,832 individuals (28.07%) were identified as having testosterone deficiency (TD), defined as an STT level below 300 ng/dL. A significant positive correlation between STB and STT levels was observed in both crude and adjusted models (all P < 0.0001). The association between STB and STT levels was found to be statistically significant up to a threshold of 17.1 µmol/L, after which it became statistically insignificant(P for non-linearity = 0.0035). Weighted logistic regression analysis indicated that a 1 µmol/L increase in STB was associated with a 4% decrease in the likelihood of TD (odds ratio = 0.96, P < 0.0001). Subgroup analysis showed that the inverse relationship was limited to individuals aged 60 and over, non-smokers/drinkers, and obese individuals. Conclusion STB within the physiological range(17.1 µmol/L) was positively associated with STT in adult males. The potential protective role of bilirubin regarding testosterone levels merits further exploration.

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Associations between serum bilirubin levels and essential trace elements status in an adult population

Cited by 5 publications

References 35 publications

Serum redox markers in uncomplicated type 2 diabetes mellitus accompanied with abnormal iron levels

Serum redox markers in uncomplicated type 2 diabetes mellitus accompanied with abnormal iron levels

How Do Minerals, Vitamins, and Intestinal Microbiota Affect the Development and Progression of Heart Disease in Adult and Pediatric Patients?

Positive association between serum bilirubin within the physiological range and serum testosterone levels

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