Associations Between the Lead Level in Maternal Blood and Umbilical Cord Blood and Congenital Heart Diseases in Offspring

Huang, Lei; Mao, Baohong; Jia-yue, LI; Nan, Nan; He, Ling; Qiu, Jie; Yi, Bin; Liu, Qing

doi:10.1007/s12011-022-03338-9

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…It has been found that serum magnesium concentration in patients with chronic kidney disease is lower than that of controls and is negatively correlated with the development of chronic kidney disease. This is consistent with the ndings of Yusuke Sakaguchi et al (Kim and Park, 2014;Li and Zhou, 2011) Dietary supplementation with selenium and coenzyme Q10 was found to signi cantly improve renal function in the intervention group (Alehagen et al, 2020), and have a positive effect on the pathogenic process of CKD (Nan et al, 2023;Xie et al, 2022) which is consistent with the results of this study. However, there are still controversial studies on the association between Se and CKD, while some studies have concluded contrary to previous ones that selenium supplementation is not bene cial and may even cause damage in CKD patients (Fu et al, 2022;Rayman et al, 2018).…”

Section: Discussionsupporting

confidence: 93%

Association between exposure to a mixture of metals and chronic kidney disease: Comparison of statistical models

Wu,

Hou,

Qin

et al. 2023

Preprint

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Previous studies have identified several genetic and environmental risk factors for chronic kidney disease (CKD), but little is known about the relationship between blood metals and CKD risk. Herein, we examined associations between serum levels of metals and the risk of CKD among 100 medical examiners and 443 patients with CKD participating in the medical center of the First Hospital Affiliated to China Medical University. Therefore, we aimed to conduct some statistical approaches, machine learning, logistics regression, Bayesian Kernel Machine Regression (BKMR) and serial mediation model, to explore the prediction and effect of metals exposure on CKD. In this cross-sectional study, the concentrations serum of metals mixtures was measured using inductively coupled plasma mass spectrometry (ICP-MS). The result suggested that exposure to K, Na and Ca lead to CKD increasing and Se and Mo lead to CKD decreasing. A significant negative effect of metal mixtures on CKD when metal mixtures concentrations were all from 30th to 45th percentile compared to the median, whereas the opposite was true for the 55th to 60th percentiles. A change in blood K concentration from the 25th to the 75th percentile is associated with a significant increase in CKD disease of 5.15(1.77,8.53), 13.62(8.91,18.33) and 31.81(14.03,49.58) when other metals are fixed at the 25th, 50th and 75th percentiles, respectively. Finally, our findings suggested that metal cumulative exposures and particularly double-exposure of K and Se might impact CKD. Machine learning could verify the external validation of the metal factors.

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Section: Discussionsupporting

confidence: 93%

Association between exposure to a mixture of metals and chronic kidney disease: Comparison of statistical models

Wu,

Hou,

Qin

et al. 2023

Preprint

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“…The cases were grouped into isolated defects (43 cases), multiple defects (46 cases), and syndrome defects (eight cases). More detailed information on the study population selection can be found in our previous studies ( Huang et al, 2022 ; Mao et al, 2017 ; Sun et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

“…These samples were then stored frozen at −80 °C in our hospital’s central laboratory until analysis. The detail in detection process of concentrations of 27 Al and 56 Fe by inductively coupled plasma mass spectrometry (ICP-MS; Themo Scientific, Bremen, Germany) were published in our previous studies ( Huang et al, 2022 ; Sun et al, 2022 ). Quality control was ensured using Elements Whole Blood L-1 (No: 210113, purchased from Beijing Fubo Biotechnology Co., Ltd).…”

Section: Methodsmentioning

confidence: 99%

Association between aluminum and iron exposure in maternal blood and umbilical cord blood and congenital heart defects in children

Li,

Zhang,

Mao

et al. 2024

PeerJ

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Background Congenital heart disease (CHDs) is the major cause of mortality from birth defects, affecting up to 1% of live births worldwide. However, the relationship between aluminum (Al) and iron (Fe) levels and the risk of CHDs has yielded inconsistent results. Methods We conducted a pair-matched case–control study that included 97 CHDs and 194 non-CHDs to investigate the association and interaction between Al/Fe exposure and the risk of CHDs in a birth cohort study in Lanzhou, China. Results Higher concentrations of cord blood Al were associated with a greater risk of total CHDs (aOR = 2.826, 95% CI [1.009–7.266]) and isolated CHDs (aOR = 10.713, 95% CI [1.017–112.851]) compared to the lowest Al level. Both in maternal blood and cord blood, a significant dose-effect was observed between Al level and total CHDs (Ptrend < 0.05), but a similar pattern was not observed for Fe. High Al in addition to high Fe appeared to elicit a stronger association with CHDs than both lowest tertile of Al and Fe level in umbilical cord blood, particularly for multiple CHDs, septal defects and patent ductus arteriosus. Conclusions Our study suggests that exposure to Al during pregnancy (≥2,408 μg/L) is significantly associated with an increased risk of CHDs in offspring, especially septal defects, and that high levels of Al and Fe are strongly correlated with fetal heart development. Further research is needed to understand the underlying mechanisms.

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“…Due to hormonal changes, deposits of lead that have been accumulating in the mother’s bones and teeth for years as a result of a polluted environment are released into her circulation during pregnancy. [ 6 7 ] Exposure to lead during a person’s prenatal and postnatal development can substantially disrupt their neurocognitive system, resulting in the onset of attention deficit hyperactivity disorder (ADHD). Lead is a neurotoxic metal.…”

Section: Introductionmentioning

confidence: 99%

Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital

Sahu,

Yogeshbhai,

Oza

et al. 2024

Journal of Family Medicine and Primary Care

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Background and Aim: With the growth of the world’s economy and industrialization, lead (Pb) contamination in the environment has become a major issue on a global scale. Lead is typically linked to unfavorable pregnancy outcomes such as stillbirth, low birth weight preterm, and spontaneous abortion. In this study, we evaluated the blood lead levels of pregnant women and their birth outcomes attending an Indian tertiary care teaching hospital, those who were not exposed to any lead-associated industry or shops. Methods: A descriptive study was undertaken to evaluate blood lead estimation in pregnant women and umbilical blood lead levels in a community hospital. Blood samples from 104 mothers during the 1st trimester, 90 mothers during 3rd trimester, and from the umbilical cord were collected. Self-administered questionnaires were used to collect information on demographics, medical history, and concerns linked to pregnancy. Following acid digestion, the levels of lead in whole blood were determined by an atomic absorption spectrometer. The DNA damage in high blood lead-concentrated pregnant women was evaluated by comet assay methods. Results: Among 194 blood samples of pregnant women, 31 (15.98%) samples revealed ≥5 μg/dL blood lead levels. High lead concentration (≥5 µg/dL) in 1st trimester pregnant women, end of 3rd trimester and cord blood were detected 20.19%, 11.11% and 1.11% respectively. The mean blood lead levels in 1st trimester, 3rd trimester, and cord blood were 3.88 ± 3.19, 2.66 ± 1.82, and 1.53 ± 1.06 mg/dL, respectively. The blood lead concentrations were significantly higher in the 1st trimester of pregnancy than in the 3rd trimester of pregnancy (P < 0.0017). A positive correlation between maternal and infant blood lead levels was revealed (P < 0.0001). When the comet assay was used to assess the genotoxic consequences of elevated blood lead levels during pregnancy, higher amounts of DNA damage were found in the samples (P < 0.01). Conclusion: In this descriptive study, there was a significant amount of lead transferred from mother to baby through the placenta. All mothers were not exposed to lead-associated industry and most were housewives. This article may be viewed as an eye-opener for understanding the blood lead concentration during pregnancy to avoid abnormal birth outcomes. To minimize exposure to environmental lead, all possible measures should be undertaken.

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Associations Between the Lead Level in Maternal Blood and Umbilical Cord Blood and Congenital Heart Diseases in Offspring

Cited by 8 publications

References 37 publications

Association between exposure to a mixture of metals and chronic kidney disease: Comparison of statistical models

Association between exposure to a mixture of metals and chronic kidney disease: Comparison of statistical models

Association between aluminum and iron exposure in maternal blood and umbilical cord blood and congenital heart defects in children

Blood lead levels in pregnant women and their newborn infants at an Indian teaching hospital

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