Associations Between the Prognostic Nutritional Index and Morbidity/Mortality During Intestinal Resection in Patients with Ulcerative Colitis

Chohno, Teruhiro; Uchino, Motoi; Sasaki, Hirofumi; Bando, Toshihiro; Takesue, Yoshio; Ikeuchi, Hiroki

doi:10.1007/s00268-017-4411-y

Cited by 14 publications

(15 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CRP is a sensitive indicator reflecting whether the body is infected or not. CRP has been reported to increase significantly when infection occurs after resection (22). A study has also shown that TNF-α is the initial factor of inflammatory response in SAP complicated with PP.…”

Section: Discussionmentioning

confidence: 96%

Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP

et al. 2020

View full text Add to dashboard Cite

The study aimed to investigate the clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis (SAP) and pancreatic pseudocyst (PP), and its effects on serum inflammatory factors. Altogether 94 patients complicated with SAP and PP who were admitted to Weifang People's Hospital (Weifang, China) from September 2015 to December 2018 were included. Based on the different operation methods, 49 patients who underwent traditional laparotomy under laparoscopic surgery were included in group A, and 45 patients who underwent duodenoscopy and laparoscopy under duodenoscope to treat the drainage of nipple and pancreatic pseudocysts were included in group B. The expression levels of related serum indexes and serum stress indexes before and at 48 h after surgery, the postoperative nausea, vomiting and abdominal pain scores, as well as the clinical efficacy, perioperative related indexes, recovery and complications were compared between the two groups. The prognostic factors in both groups were assessed via Logistic univariate and multivariate analyses. C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-β (IL-β), endotoxin and nuclear factor κB (NF-κB) were significantly lower in group B than those in group A (P<0.001). Upregulating cortisol and norepinephrine in group B was lower than that in group A (P<0.001). The total effective rate in group B was higher than that in group A (P<0.05). The perioperative related indexes, recovery, and postoperative complications in group B were better than those in group A (P<0.05). Scores of abdominal pain, nausea and vomiting in group B were markedly lower than those in group A (P<0.001). Multivariate Logistic regression analysis showed that CRP, TNF-α, IL-6, IL-β and surgical methods were independent risk factors for the prognosis of patients with SAP and PP. In conclusion, the combined treatment with duodenoscopy and laparoscopic surgery has little inflammatory and stress reaction, and it is highly safe, worthy to be popularized.

show abstract

Section: Discussionmentioning

confidence: 96%

Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In this study, the negative correlation between hs-CRP and CFR was found in IBD patients in remission. The association of lower PNI levels with mortality/morbidity in UC patients undergoing surgery has been shown in another novel study 27 . In our study, lower PNI levels were found to be associated with decreased CFR in IBD patients in remission.…”

Section: Discussionmentioning

confidence: 78%

The impact of prognostic nutritional index on coronary flow reserve in patients with inflammatory bowel disease

Çalışkan¹,

Tatlısu²,

Kahraman³

et al. 2019

MMJ

View full text Add to dashboard Cite

Objective:The recurring inflammation of mucosal layer of intestines is known as inflammatory bowel disease (IBD), which can be accompanied by nutritional deficiencies. The association between inflammation and coronary artery disease has been established. Coronary flow reserve (CFR), which is an established method to evaluate combined microvascular and epicardial flow of coronary arteries, can be assessed by using transthoracic echocardiography. The aim of this study was to evaluate the association of Prognostic Nutritional Index (PNI) with CFR in IBD patients. Method: This prospective study included 101 patients with IBD. These patients were compared to control group (n=32). PNI was calculated by using serum albumin level and lymphocyte count. CFR was assessed by using Doppler echocardiography. Results: Multivariate regression analysis indicated that the presence of IBD, age (>40 years) and decreased PNI (<53.8) independently predict impairment of CFR. The area under the curve (AUC) was 75.1% (95% CI:0.664-0.838), and PNI levels were significant predictor of low CFR (p<0.001). Conclusion: This study showed that PNI, which is calculated using the serum level of albumin and lymphocyte count, is a strong predictor of decreased CFR in IBD patients in remission. Our findings support previous studies showing the relationship between PNI and coronary artery disease. This immunonutritional index has only two components and is easy to calculate, and inexpensive.Keywords: Coronary flow reserve, inflammatory bowel disease, prognostic nutritional index ÖZ Amaç: Nutrisyonel yetersizliklerin eşlik edebildiği bağırsak mukoza katmanının tekrarlayıcı inflamasyonu, inflamatuvar bağırsak hastalığı (İBH) olarak bilinmektedir. İnflamasyon ve koroner arter hastalığının ilişkisi ortaya konulmuştur. Mikrovasküler ve epikardiyal akımı kombine bir şekilde değerlendirebilen koroner akım rezervi (KAR), transtorasik ekokardiyografi ile değerlendirilebilir. Bu çalışmanın amacı, İBH hastalarında prognostik nutrisyonel indeks (PNI) ile KAR arasındaki ilişkiyi değerlendirmekti. Yöntem: Bu çalışma, prospektif olarak dahil edilen 101 İBH hastasını içermektedir. Bu hastalar kontrol grubu (n=32) ile karşılaştırılmıştır. PNI, serum albümin düzeyi, lenfosit sayısı kullanılarak hesaplanmıştır. KAR, doppler ekokardiyografi ile değerlendirilmiştir. Bulgular: Çok değişkenli regresyon analizi İBH varlığı, yaş (>40) ve azalmış PNI'nın (<53,8) KAR'daki bozulmayı bağımsız bir şekilde predikte ettiğini ortaya çıkarmıştır. Eğri altında kalan alan (AUC) %75'di (95% CI: 0,664-0,838) ve PNI seviyesi düşük KAR için anlamlı bir prediktördü (p<0,001). Sonuç: Bu çalışma göstermiştir ki serum albümin seviyesi, lenfosit sayısı ile hesaplanan PNI, remisyondaki İBH hastalarında azalmış KAR için güçlü bir prediktördür. Çalışmamız PNI ile koroner arter hastalığı ilişkisini gösteren önceki çalışmaları desteklemektedir. Bu immunonutrisyonel indeks sadece iki komponente sahiptir, kolayca hesaplanabilir ve ucuzdur.Anahtar kelimeler: Koroner akım rezervi, inflamatuvar bağırsak h...

show abstract

“…There were no statistically significant differences for mortality in ICU between the low OPNI group (18.6%) and the high OPNI group (13.3%) (P=0.027). The median (IQR) length of stay in ICU was 17 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) days and 11 (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) days for the low OPNI group and the high OPNI group, respectively (P=0.042).…”

Section: Resultsmentioning

confidence: 99%

Associations between systemic inflammation and intestinal permeability with Onodera's prognostic nutritional index in critically ill patients

2021

View full text Add to dashboard Cite

Background: Malnutrition is a potentially costly problem in critically ill patients admitted to the intensive care unit (ICU). The aim of this study is to evaluate the relationships between the Onodera's prognostic nutritional index (OPNI) and intestinal permeability and between OPNI and systemic inflammation in critically ill patients.Methods: This was a cross-sectional study conducted in the general ICU of a university-affiliated hospita l. A total of 162 ICU-hospitalized adult patients admitted between May 2018 and December 2019, was in cluded in the study sample. The OPNI was calculated at admission and categorized as ≤40 or >40. We ass essed plasma endotoxin and zonulin concentrations as markers of intestinal permeability as well as serum interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) as markers of systemic inflammatio n upon admission under stringent conditions. The relationships between these markers and OPNI were ass essed after adjusting for potential confounders through estimation of a binary logistic regression model.Results: Median (interquartile range) hs-CRP, IL-6 zonulin, and endotoxin were significantly greater in t he low OPNI subgroup than in the high OPNI subgroup (all P<0.05). Multivariate analyses showed signifi cant association between serum IL-6 (odds ratio [OR], 0.88; 95% confidence interval [CI], 0.64-0.96), ser um hs-CRP (OR, 0.77; 95% CI, 0.53-0.92), plasma endotoxin (OR, 0.81; 95% CI, 0.72-0.93), and plasm a zonulin (OR, 0.83; 95% CI, 0.75-0.98) levels with OPNI in the overall population. Conclusions:Our results provide evidence that higher plasma endotoxin, zonulin, IL-6, and hs-CRP level s are associated with progressively lower OPNI in mixed ICU populations, particularly in surgical ICU pa tients.

show abstract

Associations Between the Prognostic Nutritional Index and Morbidity/Mortality During Intestinal Resection in Patients with Ulcerative Colitis

Abstract: Lower O-PNI may predict the prognosis in patients with UC. O-PNI may be a useful indicator for decision-making regarding surgical timing and procedure.

Cited by 14 publications

References 34 publications

Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP

Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP

The impact of prognostic nutritional index on coronary flow reserve in patients with inflammatory bowel disease

Associations between systemic inflammation and intestinal permeability with Onodera's prognostic nutritional index in critically ill patients

Contact Info

Product

Resources

About