Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis

Abstract

This meta-analysis confirms that the TNFAIP3 polymorphisms are associated with RA susceptibility in different ethnic groups, namely, in Europeans for rs6920220 and in Asians for rs10499194.

TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis

“…Previously, Lee et al also performed a meta-analysis to investigate TNFAIP3 gene rs10499194 polymorphism with RA susceptibility [25]. They indicated that rs10499194 polymorphism was not associated with RA susceptibility [25].…”

“…They indicated that rs10499194 polymorphism was not associated with RA susceptibility [25]. Stratification analyses of ethnicity in their meta-analysis [25] suggested that rs10499194 polymorphism was weakly associated with an increased risk of RA among Asian populations, while no association was observed among Caucasian populations.…”

“…They indicated that rs10499194 polymorphism was not associated with RA susceptibility [25]. Stratification analyses of ethnicity in their meta-analysis [25] suggested that rs10499194 polymorphism was weakly associated with an increased risk of RA among Asian populations, while no association was observed among Caucasian populations. However, our meta-analysis found that rs10499194 polymorphism was significantly associated with a decreased risk of RA among Caucasian populations, but not among Asian populations, indicating that diversity inheritance of different ethnicities.…”

“…The clinical heterogeneity, different ethnicities and small sample sizes may explain it. We think previous meta-analysis [25] conducted by Lee et al had several limitations. First, Lee et al did not include two studies [7, 16] which actually conformed to the inclusion criteria.…”

Contribution OF Non-HLA Genes to Juvenile Idiopathic Arthritis Susceptibility

“…3). Оба полиморф-ных маркера (rs6920220 и rs10499194), расположенные в гене TNFAIP3 и показавшие связь с ЮИА, также показа-ли сильно выраженную ассоциацию с РА [39]. Кроме того, найдены различные варианты гена TNFAIP3, вовлеченные в патогенез системной красной волчанки, псориаза, целиа-кии, что свидетельствует о предрасполагающей роли этого гена в патогенезе многих аутоиммунных болезней.…”