Associations of Four sensitization patterns revealed by Latent Class Analysis with Clinical symptoms: A multi-center study of China

Rhinitis symptom in patients with self‐reported allergic rhinitis is influenced by sensitization pattern: A cross‐sectional study of China

“…In addition, it can be seen that the four classes varied widely in geographical distribution in our study. In line with previous studies, 9,20 significantly higher positive rates of allergies to pollen were seen in patients living in Northwest and North China with a dry and cold arid climate, while the prevalence of HDM sensitization is extremely higher in South, Southwest, and East China, with ambient humidity and higher temperatures.…”

“…To our knowledge, few previous studies have examined the influence of allergen sensitization patterns revealed by LCA on the severity of patients with AR. In a previous study, 9 we defined four latent atopic classes based on performing skin prick tests on multiple allergens, to examine allergy symptoms among various sensitization groups. However, as it is well known that immunoglobulin E (IgE) is directly related to atopic diseases, it was an omission that the study did not include specific IgE (sIgE) testing in the analysis.…”

Patterns of aeroallergen sensitization in asthma patients identified by latent class analysis: A cross‐sectional study in China

“…Similar results were observed in preceding studies conducted in Qatar, 25 Iran 26 and Saudi Arabia, 27 manifesting that HDMs sensitization was more common in early As shown herein, the notable coexistence between AC and asthma was observed in patients sensitized to HDMs from eastern regions (Class 2 and Class 3) or pollens from western cohorts (Class 1 and Class 2) in our study. Consistent with preceding researches, patients allergic to mites 28 and pollens 29 showed a tendency of suffering from AC more frequently, indicating that sensitization to mites or pollens may be a risk factor in atopy diseases. Food allergy was noticed in asthmatic patients sensitized to pollens in eastern regions (Class 1), presenting a relatively high prevalence than in other categories.…”

Clarifying the use of hierarchical clustering in analyzing allergen molecule sensitization profiles

“…In essence, we did not perceive our results as contradicting existing findings. 3 The Ukrainian study, 4 employing Bayesian network (BN) analysis with a substantial number of participants, used graphical models to illustrate probabilistic dependencies between AM sensitizations. However, in contrast to our study, they did not delve into disease-specific profiles.…”