Associative relations between hypofunction of the thyroid gland of various origins and iron deficiency anemia

Гончарова, О.А.

doi:10.18370/2309-4117.2020.51.60-62

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Disruption of the gastrointestinal tract in patients with AIT was caused by the influence of thyroid hormones. With a decrease in thyroid hormones in hypothyroidism, the level of mucinous edema of the gastrointestinal tract mucosa, the secretion of gastric juice decreases, peristalsis and food passage slow down, the muscle tone of the stomach and the lower esophageal sphincter decreases, which causes the occurrence of GERD [4,9].…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Ultrasound Parallels in Diagnosis of Gastroesophageal Reflux Disease and Autoimmune Thyroiditis

Yarantseva¹,

Oparin²

2020

EUREKA: Health Sciences

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The aim of the work: to study the relationship of ultrasound parameters of the thyroid gland with the clinical course, the level of thyroid hormones and indicators of the motor-secretory function of the gastrointestinal tract in patients with gastroesophageal reflux disease (GERD) and autoimmune thyroiditis (AIT). Materials and methods. The study involved three groups of patients. The first group consisted of 22 patients with isolated GERD. The second group included 20 patients suffering from GERD in combination with AIT in the hypothyroid stage. And the third group included 20 patients suffering from isolated AIT in the hypothyroid stage. The control group consisted of 15 apparently healthy individuals of the same age and sex. All patients underwent a comprehensive examination, which included the necessary set of clinical, laboratory and instrumental research methods in accordance with the local treatment protocols such as collection of complaints and anamnesis, patient examination, physical examination, clinical and biochemical analyzes, ECG, EGD, intragastric pH-metry. The patients underwent ultrasound examination of the motor-evacuation function of the esophagus and stomach with water load and an ultrasound examination of thyroid gland. The functional activity of thyroid gland was assessed by determining the level of thyroid hormones (TSH, T4 free, T3) by ELISA and the presence of antibodies to. Results. The study involved three groups of patients: patients with isolated gastroesophageal reflux disease, patients with a combined course of GERD and AIT in the hypothyroid stage and patients with isolated AIT in the hypothyroid stage. The most pronounced complaints, a higher level of thyroid-stimulating hormone and the most pronounced ultrasound changes are noted in patients with combined pathology. Ultrasound examination of the lower third of esophagus and stomach in patients of all three groups showed the presence of regurgitation, expansion of the lumen of the lower third of esophagus and an increase in the diameter of esophageal opening of diaphragm in varying degrees, in contrast to patients in the control group. Thus according to the results of thyroid sonography and ultrasound examination of the motor function of the lower third of esophagus and stomach, the most pronounced changes were found in the second group of patients who had a combined course of GERD and AIT. Conclusions. 1. A clear correlation was established between the clinical course, an increase in the level of thyroid hormones and ultrasound picture of thyroid gland and indicators of the motor-secretory function of the gastrointestinal tract in patients with GERD and AIT; It was shown that disorders in the activity of thyroid hormones affect the formation of motor-secretory disorders in patients with GERD with concomitant AIT which mutually aggravates the course of this comorbid pathology; Ultrasound diagnostics can be used as an evaluative method in this category of patients.

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Section: Discussionmentioning

confidence: 99%

“…One of these diseases is autoimmune thyroiditis (AIT). AIT is one of the most common thyroid diseases [4]. Both of these diseases have several common pathogenetic mechanisms, the main of which are thyroid hormones, which regulate the processes of motility and secretion of the gastrointestinal tract [5,6].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Ultrasound Parallels in Diagnosis of Gastroesophageal Reflux Disease and Autoimmune Thyroiditis

Yarantseva¹,

Oparin²

2020

EUREKA: Health Sciences

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Current concepts about influence of thyroid gland hormones on the development and course of gastro-esophageal reflux disease

Oparin,

Yarantseva

et al. 2023

Shidnoevr. z. vnutr. simejnoi med.

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The problem of gastroesophageal reflux disease (GERD) remains one of the most relevant in modern gastroenterology. In recent decades, there has been a tendency to increase in the incidence of GERD especially among young people. Symptoms of GERD occur in almost half of the adult population. The main symptom of GERD — intermittent heartburn, which significantly reduces the quality of life, noted in up to 40% of residents of industrialized countries. However, the real prevalence of GERD in the population has not been studied enough due to the low rate of medical treatment seeking, frequent asymptomatic course as well as the course of the disease under masks, the so-called «esophageal» manifestations. At the same time, the number of patients with GERD with combined pathology is growing. One such disease is autoimmune thyroiditis (AIT). AIT — is one of the most common diseases of the thyroid gland. Autoimmune inflammatory process in the thyroid gland leads to the constant production of autoantibodies to thyroperoxidase or thyroglobulin and further leads to permanent destruction of the thyroid gland with the subsequent development of hypothyroidism. Early diagnosis of AIT allows to timely treatment and maintains thyroid function. Both of these diseases have several common pathogenetic mechanisms, the main of which are thyroid hormones that regulate motility and secretion of the gastrointestinal tract. The comorbid course of these pathologies aggravates and modifies the clinical picture each other. For today, the role of thyroid hormones in the mechanism of formation of motor-secretory disorders in patients with GERD with concomitant AIT, their impact on the peculiarities of the formation of psychosomatic status, as well as gender features of GERD and AIT remains unexplored.

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Vitamin D deficiency increases the risk of bacterial vaginosis during pregnancy: Evidence from a meta-analysis based on observational studies

Zhang

et al. 2022

Front. Nutr.

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BackgroundBacterial vaginosis (BV) is the most common microbiological syndrome in women of childbearing age, causing numerous adverse health issues in pregnant women. Several observational studies have discussed the association between vitamin D deficiency and the risk of BV during pregnancy, but the results were inconclusive. Therefore, this meta-analysis aimed to explore the association between vitamin D deficiency and BV risk in pregnant women.Materials and methodsWe searched four databases, including PubMed, Embase, Cochrane Library, and Web of Science, from their inception to July 2022. Pooled odds ratios (OR) with corresponding 95% confidence intervals (CI) were estimated using random effects models. Additionally, we conducted subgroup analyses to identify the potential sources of between-study heterogeneity. Sensitivity analysis was performed using the method of exclusion, one study at a time. Publication bias was examined using Egger’s test and funnel plot.ResultsA total of 14 studies from 13 articles including 4,793 participants were eligible for this meta-analysis. The outcome showed that vitamin D deficiency may increase the risk of BV during pregnancy by 54% (OR, 1.54; 95% CI, 1.25–1.91; P < 0.001). In subgroup analyses, positive associations were also found in studies that were: conducted in black women (OR, 1.56; 95% CI, 0.98–2.48; P = 0.060), focused on the first trimester of pregnancy (OR, 2.22; 95% CI, 1.35–3.64; P = 0.002), of high quality (OR, 3.05; 95% CI, 1.26–7.41; P = 0.014), and adjusted for confounders (OR, 1.28; 95% CI, 1.06–1.55; P = 0.012). Sensitivity analysis reported that BV risk during pregnancy resulting from vitamin D deficiency increased by 157% (OR, 2.57; 95% CI, 1.50–4.42; P = 0.001) when removing the first two high-weight studies. Publication bias was observed using Egger’s test (t = 3.43, P = 0.005) and a visual funnel plot.ConclusionThis meta-analysis showed that vitamin D deficiency is positively associated with the risk of BV during pregnancy. Further high-quality prospective cohort studies are needed to determine whether vitamin D intake reduces the prevalence of BV in pregnant women.

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Associative relations between hypofunction of the thyroid gland of various origins and iron deficiency anemia

Cited by 3 publications

References 18 publications

Clinical and Ultrasound Parallels in Diagnosis of Gastroesophageal Reflux Disease and Autoimmune Thyroiditis

Clinical and Ultrasound Parallels in Diagnosis of Gastroesophageal Reflux Disease and Autoimmune Thyroiditis

Current concepts about influence of thyroid gland hormones on the development and course of gastro-esophageal reflux disease

Vitamin D deficiency increases the risk of bacterial vaginosis during pregnancy: Evidence from a meta-analysis based on observational studies

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