Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19

Ahmadi, Alireza; Ayazi‐Nasrabadi, Roya

doi:10.18502/ijm.v13i4.6965

Cited by 13 publications

(15 citation statements)

References 55 publications

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“…can be regulated and suppressed by the supplementation of AST. So it can be a promising therapeutic dietary supplement along with primary antiviral medications for the patients suffering from severe pneumonitis, acute lung injury (ALI), Acute Respiratory Distress Syndrome (ARDS), other lungs related infections and also in recovered patients of COVID-19 as a post-treatment care [ 258 – 260 ].…”

Section: Pharmaceutical Potential Of Astaxanthin In Chronic Diseasesmentioning

confidence: 99%

Pharmaceutical and nutraceutical potential of natural bioactive pigment: astaxanthin

Patil

Kasabe

Dandge

2022

Nat. Prod. Bioprospect.

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Astaxanthin (3,3′-dihydroxy-β,β-carotene-4,4′-dione) is an orange-red, lipophilic keto-carotenoid pigment. It is majorly found in marine ecosystems particularly in aquatic animals such as salmon, shrimp, trout, krill, crayfish, and so on. It is also synthesized in microalgae Heamatococcus pluvialis, Chlorococcum, Chlorella zofingiensis, red yeast Phaffia rhodozyma and bacterium Paracoccus carotinifaciens. Some aquatic and terrestrial creatures regarded as a primary and secondary sources of the astaxanthin producing and accumulating it through their metabolic pathways. Astaxanthin is the powerful antioxidant, nutritional supplement as well as promising therapeutic compound, observed to have activities against different ravaging diseases and disorders. Researchers have reported remarkable bioactivities of astaxanthin against major non-communicable chronic diseases such as cardiovascular diseases, cancer, diabetes, neurodegenerative, and immune disorders. The current review discusses some structural aspects of astaxanthin. It further elaborates its multiple potencies such as antioxidant, anti-inflammatory, anti-proliferative, anti-cancer, anti-obese, anti-diabetic, anti-ageing, anti-TB, anti-viral, anti-COVID 19, neuro-protective, nephro-protective, and fertility-enhancing properties. These potencies make it a more precious entity in the preventions as well as treatments of prevalent systematic diseases and/or disorders. Also, the review is acknowledging and documenting its powerful bioactivities in relation with the pharmaceutical as well as nutraceutical applicability. Graphical Abstract

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Section: Pharmaceutical Potential Of Astaxanthin In Chronic Diseasesmentioning

confidence: 99%

Pharmaceutical and nutraceutical potential of natural bioactive pigment: astaxanthin

Patil

Kasabe

Dandge

2022

Nat. Prod. Bioprospect.

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“…The exact mechanism of action against these microorganisms is not known [ 121 ]. Due to known regulatory properties of AX for the expression of pro-inflammatory factors as well as antiviral effects, it has been explored as potential adjuvant therapy for COVID-19 disease [ 122 , 123 , 124 ].…”

Section: Miscellaneous Natural Productsmentioning

confidence: 99%

Introduction to Traditional Medicine and Their Role in Prevention and Treatment of Emerging and Re-Emerging Diseases

et al. 2022

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Infectious diseases have been a threat to human health globally. The relentless efforts and research have enabled us to overcome most of the diseases through the use of antiviral and antibiotic agents discovered and employed. Unfortunately, the microorganisms have the capability to adapt and mutate over time and antibiotic and antiviral resistance ensues. There are many challenges in treating infections such as failure of the microorganisms to respond to the therapeutic agents, which has led to more chronic infections, complications, and preventable loss of life. Thus, a multidisciplinary approach and collaboration is warranted to create more potent, effective, and versatile therapies to prevent and eradicate the old and newly emerging diseases. In the recent past, natural medicine has proven its effectiveness against various illnesses. Most of the pharmaceutical agents currently used can trace their origin to the natural products in one way, shape, or form. The full potential of natural products is yet to be realized, as numerous natural resources have not been explored and analyzed. This merits continuous support in research and analysis of ancient treatment systems to explore their full potential and employ them as an alternative or principal therapy.

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“…One such inhibitor, amantadine, a licensed anti-influenza drug, was shown to significantly inhibit CTSL activity after SARS-CoV-2 pseudovirus infection by suppressing transcription of the CTSL-encoding gene to prevent SARS-CoV-2 infection both in vitro and in vivo [ 74 , 75 , 76 ]. Another CTSL inhibitor, teicoplanin, is a glycopeptide antibiotic that appears to inhibit SARS-CoV-2 infection by inhibiting CTSL activity [ 77 ], while astaxanthin, a potential immunomodulatory antioxidant agent, was shown to suppress CTSL activity in both Syrian hamster embryo cells and muscle cells [ 5 , 78 , 79 ]. Meanwhile, numerous other potential CTSL inhibitors were discovered within the FDA-approved drug inventory database that may effectively block SARS-CoV-2 infection, as summarized in earlier reviews [ 73 , 80 ].…”

Section: Targeting Lysosome-based Replication Of Sars-cov-2 As a Pote...mentioning

confidence: 99%

Potential Antiviral Strategy Exploiting Dependence of SARS-CoV-2 Replication on Lysosome-Based Pathway

Lan

Wang³

et al. 2022

IJMS

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The recent novel coronavirus (SARS-CoV-2) disease (COVID-19) outbreak created a severe public health burden worldwide. Unfortunately, the SARS-CoV-2 variant is still spreading at an unprecedented speed in many countries and regions. There is still a lack of effective treatment for moderate and severe COVID-19 patients, due to a lack of understanding of the SARS-CoV-2 life cycle. Lysosomes, which act as “garbage disposals” for nearly all types of eukaryotic cells, were shown in numerous studies to support SARS-CoV-2 replication. Lysosome-associated pathways are required for virus entry and exit during replication. In this review, we summarize experimental evidence demonstrating a correlation between lysosomal function and SARS-CoV-2 replication, and the development of lysosomal perturbation drugs as anti-SARS-CoV-2 agents.

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Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19

Cited by 13 publications

References 55 publications

Pharmaceutical and nutraceutical potential of natural bioactive pigment: astaxanthin

Pharmaceutical and nutraceutical potential of natural bioactive pigment: astaxanthin

Introduction to Traditional Medicine and Their Role in Prevention and Treatment of Emerging and Re-Emerging Diseases

Potential Antiviral Strategy Exploiting Dependence of SARS-CoV-2 Replication on Lysosome-Based Pathway

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