Asterosaponins from the Starfish &lt;i&gt;Astropecten monacanthus&lt;/i&gt; Suppress Growth and Induce Apoptosis in HL-60, PC-3, and SNU-C5 Human Cancer Cell Lines

Thảo, Nguyễn Phương; Luyen, Bui Thi Thuy; Kang, Hee‐Kyoung; Kim, Young Ho; Cuong, Nguyen Xuan; Nam, Nguyễn Hoài; Kiệm, Phan Văn; Minh, Châu Văn

doi:10.1248/bpb.b13-00705

Cited by 26 publications

(17 citation statements)

References 22 publications

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“…Nghiên cứu tiếp theo cho thấy cặn chiết MeOH loài sao biển A. monacanthus và hợp chất 27 kích thích quá trình chết theo chương trình (apoptosis) ở tế bào HL-60 được xác nhận bởi sự gia tăng các thể apoptosis ở các tế bào được xử lý khi nhuộm với thuốc nhuộm Hoechst 33342 và thông qua việc điều tiết giảm con đường ERK 1/2 và C-myc ở tế bào HL-60, PC-3 và SNU-C5. [12]…”

Section: Nhóm Chất Saponinunclassified

Điểm lại các nghiên cứu hóa học và hoạt tính sinh học một số loài sinh vật biển Việt Nam trong giai đoạn 2013‐2017

Cường¹,

Nhiệm²,

Thành³

et al. 2018

Vietnam Journal of Chemistry

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Điểm lại các nghiên cứu hóa học và hoạt tính sinh học một số loài sinh vật biển Việt Nam trong giai đoạn AbstractThis paper reviews the investigations on marine natural products in Vietnam published in period of 2013-2017 from sponges, corals, echinoderms, mollusks, and microorganisms. About 415 compounds were isolated and structure elucidated including 33 saponins (15 new compounds), 143 steroids (30 new compounds), 38 steroid glycosides (20 new compounds), 33 diterpenes (20 new compounds), 53 sesquiterpenes (27 new compounds), 12 cyclopeptides, 7 pyrrole and furan oligoglycosides (6 new compounds), 10 biscembranoids (2 new compounds), 15 triterpenes (14 new compounds), and 71 other compounds (8 new compounds). Many compounds have unique structures and exhibited potential biological effects including cytotoxic, anti-inflammatory, and anti-microbial activities.

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Section: Nhóm Chất Saponinunclassified

Điểm lại các nghiên cứu hóa học và hoạt tính sinh học một số loài sinh vật biển Việt Nam trong giai đoạn 2013‐2017

Cường¹,

Nhiệm²,

Thành³

et al. 2018

Vietnam Journal of Chemistry

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Section: Introductionmentioning

confidence: 99%

“…Saponins have also been commonly employed in some other sector in medical practice because of their potential health benefits. In addition, many plant saponins have been isolated and they exhibit broad spectrum of biological uses, such as anti-cancer, anti-inflammatory, ion channel blocking, immune stimulating, antifungal, and anti-thrombotic property (Lee et al, 2014;Thao et al, 2014).The starfish A. amurensis, called the northern Pacific starfish, is a predator of the marine benthic system that is listed in the top 100 invasive species globally (Lowe et al, 2000). The species was identified as a serious pest species because of its ability to consume a wide range of food sources including mussels, scallops, and clams (Global invasive species database, 2016).…”

mentioning

confidence: 99%

Molecular identification, micronutrient content, antifungal and hemolytic activity of starfish Asterias amurensis collected from Kobe coast, Japan

Sharmin¹,

Ishizaki²,

Nagashima³

2017

Afr. J. Biotechnol.

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The starfish Asterias amurensis is one of the common species in Japanese coastal area. The species is considered an extremely rich source of biological active compounds, including saponin. Saponins are secondary metabolites and exhibit a wide spectrum of biological activities. The species of starfish caught in Kobe, Hyogo prefecture, Japan, was analyzed for species identification and micronutrient content. The starfish extract was evaluated for different biological properties and its fractions obtained using thin layer chromatography (TLC). Nucleotide sequence analysis of the 16S rRNA gene fragment of mitochondrial DNA indicated that partial sequences of PCR products of the species was identical with that of A. amurensis. The micronutrient contents results showed that nitrogen (N) content of the starfish was 1.50% of dry weight and the copper content was 2.10 µg/g. The crude extract of A. amurensis exhibited predominant growth inhibitory activity against six human fungal pathogens and also showed hemolytic activity against 2% sheep erythrocyte. The present findings suggest the possible pharmacological applications of A. amurensis that can be used as food ingredients and antifungal component.Key words: Asterias amurensis, crude extract, biological property, saponin, antifungal component. INTRODUCTIONNowadays, invasion of exotic species has become a major concern in the marine environment since the number of human-mediated introduction has increased (Ruiz et al., 2000). Many studies researching marine invertebrates to determine the therapeutic potential of their bioactive materials have been showing very promising results (Lee et al., 2014 (Ishii et al., 2006;Suh et al., 2011). Saponins are a group of natural plant glycosides, characterized by their strong foam-forming properties in aqueous solution that occur in a wide range of plant species (Osbourn, 1996). The presence of saponin has been reported in more than 100 families of plants out of which at least 150 kinds of natural saponins have been found to possess significant anti-cancer properties (Man et al., 2010). Saponins have also been commonly employed in some other sector in medical practice because of their potential health benefits. In addition, many plant saponins have been isolated and they exhibit broad spectrum of biological uses, such as anti-cancer, anti-inflammatory, ion channel blocking, immune stimulating, antifungal, and anti-thrombotic property (Lee et al., 2014;Thao et al., 2014).The starfish A. amurensis, called the northern Pacific starfish, is a predator of the marine benthic system that is listed in the top 100 invasive species globally (Lowe et al., 2000). The species was identified as a serious pest species because of its ability to consume a wide range of food sources including mussels, scallops, and clams (Global invasive species database, 2016). The wastes of them results in serious environmental pollution. Furthermore the large outbreak of starfish causes significant loss of the marine ecosystem and fishing gears (Kim, 1969). There i...

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“…Steroidal glycosides are the main metabolites of starfish and possess most toxicity (D'Auria et al, 1993). In particular, steroidal glycosides and related compounds are predominant metabolites in starfish and have a broad variety of biological activities such as cytotoxic, hemolytic, ichthyotoxic, repellent, antineoplastic, antimicrobial, antifungal, antiviral and antiinflammatory (Lee et al, 2014;Thao et al, 2014;Nina et al, 2003). Starfish has identified as a serious pest species because of its ability to consume a wide range of food sources including mussels, scallops, and clams (Global invasive species database, 2016).…”

Section: Introductionmentioning

confidence: 99%

Species identification and the biological properties of several Japanese starfish

Sharmin

Ishizaki

Nagashima

2017

Asian J. Med. Biol. Res

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Marine organisms are a rich source of natural products with potential secondary metabolites that have great pharmacological activity. Starfish are known as by-catch products in the worldwide fishing industry and most of starfish have been got rid of by fire destruction without any utilization. On the other hand, starfish are considered as extremely rich sources of biological active compounds in terms of having pharmacological activity. In the present study, molecular identification of starfish species, micronutrient content and hemolytic activity from Luidia quinaria, Astropecten scoparius, and Patiria pectinifera were examined. Nucleotide sequence analysis of the 16S rRNA gene fragment of mitochondrial DNA indicated that partial sequences of PCR products of the species was identical with that of L. quinaria, A. scoparius, and P. pectinifera. From the results of micronutrient contents, there were no great differences on the micronutrient among species. However, Cd, Cu, and as contents had species-specificity. The crude extract of three starfish showed hemolytic activity against 2% rabbit erythrocytes with 50% hemolytic concentration of 10-1000 µg/mL. The findings of the present study provided some basic information about identification of starfish species, potentialities of starfish which could be utilized in food and pharmaceutical industry.

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Asterosaponins from the Starfish <i>Astropecten monacanthus</i> Suppress Growth and Induce Apoptosis in HL-60, PC-3, and SNU-C5 Human Cancer Cell Lines

Cited by 26 publications

References 22 publications

Điểm lại các nghiên cứu hóa học và hoạt tính sinh học một số loài sinh vật biển Việt Nam trong giai đoạn 2013‐2017

Điểm lại các nghiên cứu hóa học và hoạt tính sinh học một số loài sinh vật biển Việt Nam trong giai đoạn 2013‐2017

Molecular identification, micronutrient content, antifungal and hemolytic activity of starfish Asterias amurensis collected from Kobe coast, Japan

Species identification and the biological properties of several Japanese starfish

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