Asthma and COPD overlap pathophysiology of ACO

Hikichi, Mari; Hashimoto, Shigeo; Gon, Yasuhiro

doi:10.1016/j.alit.2018.01.001

Cited by 46 publications

(36 citation statements)

References 18 publications

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“…ORs were adjusted (aOR) for sex, age, race, calendar year of selection, and measures of socioeconomic status and healthcare utilization (see Tables 2-4 notes for details). Chronic obstructive pulmonary disease (COPD) is largely caused by smoking, and there is substantial overlap in symptoms for asthma and COPD (51). We classified participants as having COPD if they had at least 1 inpatient, physician, or outpatient claim with a COPD diagnosis code (ICD-9 496) at any point after study entry.…”

Section: Methodsmentioning

confidence: 99%

Allergies and the Subsequent Risk of Cancer among Elderly Adults in the United States

D’Arcy

Rivera

Grothen

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Allergic conditions may prevent some cancers by promoting immune surveillance. We examined associations of allergic rhinitis, asthma, and eczema with cancer risk among elderly Americans. Methods: We used Surveillance Epidemiology and End Results (SEER)-Medicare linked data to perform a case-control study. Cases were individuals with first cancer diagnosed in SEER registries (1992-2013, ages 66-99; N ¼ 1,744,575). Cancer-free controls (N ¼ 100,000) were randomly selected from Medicare and matched on sex, age, and selection year. Allergic conditions were identified using Medicare claims, and logistic regression was used to estimate adjusted ORs (aOR) with significance gauged with a Bonferroni P cutoff (P < 0.00034). Results: Allergic rhinitis, asthma, and eczema were present in 8.40%, 3.45%, and 0.78% of controls, respectively. For allergic rhinitis, strong inverse associations (aORs, 0.66-0.79) were observed for cancers of the hypopharynx, esophagus (squamous cell), cervix, tonsil/oropharynx, and vagina/vulva. More modest but significant inverse associations were noted for cancers of the esophagus (adenocarcinoma), stomach, colon, rectosigmoid/rectum, liver, gallbladder, lung, uterus, bladder, and miscellaneous sites. Associations were stronger in analyses requiring a dispensed medication to confirm the presence of allergic rhinitis. Asthma was associated with reduced risk of liver cancer [aOR 0.82; 95% confidence interval (CI), 0.75-0.91], whereas eczema was associated with elevated risk of T-cell lymphoma (aOR, 4.12; 95% CI, 3.43-4.95). Conclusions: Inverse associations with allergic rhinitis are present for multiple cancers and require etiologic investigation. Impact: Understanding of mechanisms by which allergic conditions reduce cancer risk may advance cancer prevention and treatment.

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Section: Methodsmentioning

confidence: 99%

Allergies and the Subsequent Risk of Cancer among Elderly Adults in the United States

D’Arcy

Rivera

Grothen

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In 2014 the Global Initiative for Asthma (GINA) and GOLD Joint Committee came out with the definition: "Asthma-COPD overlap syndrome" (ACOS) is characterised by persistent airflow limitation with several features usually associated with asthma and several features usually associated with COPD. It is therefore identified by the features that it shares with both asthma and COPD" 40 . Subsequently, the term "syndrome" came to be considered inappropriate in this context.…”

Section: Asthma-copd Overlap Syndrome Versus High Eosinophil Copdmentioning

confidence: 99%

“…Asthma-COPD overlap is therefore identified in clinical practice by the features that it shares with both asthma and COPD. This is not a definition, but a description for clinical use, as ACO includes several different clinical phenotypes and there are likely to be several different underlying mechanisms" 40 .…”

Section: Asthma-copd Overlap Syndrome Versus High Eosinophil Copdmentioning

confidence: 99%

“…The Dutch researcher Dick Orie first proposed this hypothesis in 1961. He hypothesised that "asthma, chronic bronchitis, and pulmonary emphysema (COPD) is a single disease (chronic non-specific disease) that occurs as a result of the same genetic factors (atopic status, promotion of airway hyperreactivity), and only presents different clinical phenotypes due to different environmental factors (allergens, smoking, and infections)" 40 . This hypothesis was later reworked by Fletcher, who introduced the concept of chronic non-specific lung disease (CNLD).…”

Section: Barcelona Respiratory Networkmentioning

confidence: 99%

“…According to this hypothesis, an individual with certain genetic factors presents the clinical phenotype of COPD when exposed to smoking and the clinical phenotype of asthma when exposed to allergens. Thus, if the subject has been exposed to both environmental factors and therefore the two cannot be separated, he will develop a form of overlap of the two diseases (ACO) 40 .…”

Section: Barcelona Respiratory Networkmentioning

confidence: 99%

See 2 more Smart Citations

The Many Faces of Chronic Obstructive Pulmonary Disease: Moving Towards Precision Medicine

Polverino¹

2021

BRN

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When the term chronic obstructive pulmonary disease (COPD) was first used in 1970s, it included two main phenotypes: the "blue bloater" (chronic bronchitis) and "pink puffer" (emphysema). Recently, as our current knowledge on the disease has progressed, the attention has been drawn to very diverse subtypes of chronic airflow obstruction characterised by different causes, age of onset, pathological and clinical manifestations. Over the years, "recommendations" have been generated for the clinicians on how to manage the patients with COPD, such as the Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommendations. Although the GOLD recommendations had the great merit to draw attention onto the COPD severity and its clinical management, they are now less suitable to address the extremely diverse nature of COPD. This review will give an overview of the history of COPD, and the many faces of COPD over the years to date. (BRN Rev. 2019;5(2):90-103)

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Computer‐aided design of muscarinic acetylcholine receptor M3 inhibitors: Promising compounds among trifluoromethyl containing hexahydropyrimidinones/thiones

Nyporko

Tsymbalyuk²,

Voiteshenko³

et al. 2023

Molecular Informatics

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The new high selective mAChRs M3 inhibitors with IC50 in nanomolecular ranges, which can be the prototypes for effective COPD and asthma treatment drugs, were discovered with computational approaches among trifluoromethyl containing hexahydropyrimidinones/thiones. Compounds [6‐(4‐ethoxy‐3‐methoxy‐phenyl)‐4‐hydroxy‐2‐thioxo‐4‐(trifluoromethyl)hexahydropyrimidin‐5‐yl]‐phenyl‐methanone (THPT‐1) and 5‐benzoyl‐6‐(3,4‐dimethoxyphenyl)‐4‐hydroxy‐4‐(trifluoromethyl)hexahydropyrimidin‐2‐one (THPO‐4) have been proved to be a highly effective (with IC50 values of 1.62 ⋅ 10−7 M and 3.09 ⋅ 10−9 M, respectively) at the same concentrations significantly competitive inhibit the signal conduction through mAChR3 in comparison with ipratropium bromide, without significant effect on mAChR2, nicotinic cholinergic and adrenergic receptors.

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Asthma and COPD overlap pathophysiology of ACO

Cited by 46 publications

References 18 publications

Allergies and the Subsequent Risk of Cancer among Elderly Adults in the United States

Allergies and the Subsequent Risk of Cancer among Elderly Adults in the United States

The Many Faces of Chronic Obstructive Pulmonary Disease: Moving Towards Precision Medicine

Computer‐aided design of muscarinic acetylcholine receptor M3 inhibitors: Promising compounds among trifluoromethyl containing hexahydropyrimidinones/thiones

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