Asthma caused by bromelin inhalation

Galleguillos, F; Rodríguez, Julia Calzas

doi:10.1111/j.1365-2222.1978.tb00443.x

Cited by 38 publications

(15 citation statements)

References 2 publications

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“…In the cases of bromelain sensitization due to exposure at work, Galleguillos and Rodriguez mentioned that none of the patients described wore any safety protection and that dust inhalation was massive [10]. The working environment of the cases described by Gailhofer et al was not elucidated more closely, but in the workers investigated, frequent and intensive contact with bromelain dust has been reported [7].…”

Section: Discussionmentioning

confidence: 97%

“…In most of the concerned patients, total IgE-levels were normal indicating an absence of atopic disease [7]. In diagnostic testing, symptoms occurred after exposure to inhalable particles [10], after prick-testing [7] and even after eating a pineapple [11].…”

Section: Allergy To Bromelainmentioning

confidence: 99%

“…The observed symptoms following bromelain exposure ranged from rhinitis and ocular itching to severe asthmatic episodes requiring immediate medical treatment [7,10,11]. In some subjects, however, pineapple ingestion could trigger gastric distensions and nausea [11].…”

Section: Allergy To Bromelainmentioning

confidence: 99%

“…The reported working environments where these incidents occurred were located in pharmacologic and diagnostic laboratories. All described cases had victims that had frequently been exposed to bromelain-containing dust [7,10,11]. However, not all to bromelain exposed workers developed allergic symptoms [7].…”

Section: Allergy To Bromelainmentioning

confidence: 99%

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Low exposure levels of respirable particles during the preparation of NexoBrid® bromelain powder

et al. 2015

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Background: Burns are common injuries that are usually covered with a layer of necrotic tissue called the eschar. Early removal of the eschar is the current standard of care, however, debridement using tangential excision is usually traumatic and may increase wound surface. In recent years a bromelain-based debriding agent called NexoBrid® that can remove the eschar selectively and thus causes less additional trauma was developed. Bromelain is a pineapple-stem derived mix of proteases. In its raw form bromelain is a yellowish powder. Cases are known where frequent inhalation of bromelain dust led to respiratory sensitization and subsequently to severe allergic reactions. In order to activate bromelain for debridement it has to be mixed with a hydrating gel. We aimed to assess the risk of sensitization by measuring the particle concentration in the air during the mixing process in order to determine the safety of the product for patients as well as practitioners. Methods: The mixing process was repeated five times in a row. Samples of the particle concentration in the workers breathing area were taken with an air particle counting device during continuous performance. The worker wore a lab coat and gloves but no face mask. Results: Particle concentrations ranged from 0.010 mg/m 3 to 0.012 mg/m 3 (mean 0.010 mg/m

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Section: Discussionmentioning

confidence: 97%

Section: Allergy To Bromelainmentioning

confidence: 99%

Section: Allergy To Bromelainmentioning

confidence: 99%

Section: Allergy To Bromelainmentioning

confidence: 99%

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Low exposure levels of respirable particles during the preparation of NexoBrid® bromelain powder

et al. 2015

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“…Proteolytic enzymes of plant origin, such as bromelain (pineapples) and papain (papaya), present in the form of dust, have been shown to cause allergic diseases after inhalation (Galleguillos and Rodriguez, 1978;Baur, 1979;Baur and Fruhmann, 1979a;Keenan et al, 1979;Gailhofer et al, 1988). Bromelain is extracted from fruit and leaves of plants while papain is a sulphydryl protease extracted from the latex of papaya fruit (Carica papaya).…”

Section: Enzymic Aeroallergens Of Plant Originmentioning

confidence: 98%

Aeroallergens of plant origin: Molecular basis and aerobiological significance

1995

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This review presents an update on the sources and molecular basis of aeroallergens of plants, derived from pollen, seeds, leaf and stem detritus and their protein molecules. These aeroallergens are a natural component of the atmosphere, either because of their natural function or human activity. Pollen is a source of allergens within the 10-200 #m size range, and while most allergenic pollen types account for only 20-30~ of total annual pollen catch, during their flowering season, they are usually the dominant type. Tree pollen commences the season in winter, with birch pollen counts in Scandinavia being the highest daily pollen counts yet reported and a major allergen, a 14-kDa protein, which is similar to pathogenesis-related proteins. Grass pollen follows in spring, and is unique as its two immunodominant allergens, a 35-kDa glycoprotein and 28-32-kDa protein, are in different cellular sites: the cytosol and surface of pollen grains; and in intracellular starch granules. The allergens at the pollen surface are not inhalable and can interact only with the eyes, nasal and oral cavities. Starch granules are released to the atmospheric aerosol when grains rupture in rainwater. These are a major source of allergen-containing micronic particles, which are important because they are inhalable. At the same time, allergen molecules are present in the aerosol, and these can bind to soot particles, and so be respired deep into the airways. The major Japanese cedar pollen allergen has been detected both within the pollen and in orbicules; particles less than 1 tLm that line the anther cavity and can be released into the air when dehiscence occurs. Ragweed is the major cause of late summer hayfever in eastern North America, where its pollen accounts for up to 41% of the annual pollen catch. It is a major source of aeroallergens in both respirable and non-respirable size ranges. As a result of human activity, dusts derived from seeds and cereal grains during transport, storage and milling provide a source of micronic particles, containing potent allergens that can trigger allergic disease.

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Bromelain [MAK Value Documentation in German language, 2006]

2012

The MAK‐Collection for Occupational Health and Safety

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Asthma caused by bromelin inhalation

Cited by 38 publications

References 2 publications

Low exposure levels of respirable particles during the preparation of NexoBrid® bromelain powder

Low exposure levels of respirable particles during the preparation of NexoBrid® bromelain powder

Aeroallergens of plant origin: Molecular basis and aerobiological significance

Bromelain [MAK Value Documentation in German language, 2006]

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