Asthma control, severity, and quality of life: Quantifying the effect of uncontrolled disease

Factors associated with uncontrolled asthma in Porto Alegre, Brazil

“…There was no significant association between the level of asthma control and the number of comorbidities, and a possible explanation for this finding was that these patients were under adequate treatment so that this common marker did not influence the asthma control status. Chen et al (22) analyzed asthma control, severity and quality of life in 987 asthmatic adults and identified one or more comorbidities in 21% of patients with a mean age of 52.8 years. Similar to our findings, there was no association between the level of asthma control and the number of comorbidities.…”

EuroQol (EQ-5D-5L) Validity in Assessing the Quality of Life in Adults With Asthma: Cross-Sectional Study (Preprint)

“…First, embedding this study in an observational cohort in routine care allowed us to select several appropriate known groups for evaluating the EQ-5D-5L's construct validity in asthma patients. The relationship between comorbid chronic conditions and health is well established, and the associations of severity [2,31] and symptoms control [49] with HRQoL have been extensively studied in this population. Furthermore, the ACQ, validated in 50 languages, is one of the most widely accepted instruments for measuring symptom control [50].…”

“…Nevertheless, the high correlation consistently reported between asthma-specific HRQoL and asthma control measures [2,3] suggested some limitations in assessing HRQoL. Along this line, a recent study proposed adding HRQoL generic domains of life important to people with asthma [4].…”

Flaws in GINA Guidelines and the Solutions Thereof

“…Several studies have already demonstrated that the level of asthma control is closely linked to the use of healthcare resources, the level of lifestyle impairment, and QoL: the better is the control, the less is impairment, the lower is the use of healthcare resources and the higher is the QoL [1][2][3][4][5][6].…”