Asthma, COPD and comorbidities in elderly people

Bożek, Andrzej; Rogala, Barbara; Bednarski, Piotr

doi:10.3109/02770903.2016.1170139

Cited by 26 publications

(13 citation statements)

References 17 publications

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“…In the adult populations of Europe, North America and Australia, the incidence of COPD ranges from 4 to 10% [17], and is predicted to continue rising in European countries until at least the year 2030 [18]. Few studies have examined the incidence of COPD in Poland, and the available data varies considerably, mainly due to the age of the studied populations; however, the most recent nationwide study found 20% of patients aged 60 years or older in the selected health care centers to be affected by COPD [19].…”

Section: Introductionmentioning

confidence: 99%

Standard expected years of life lost (SEYLL) due to chronic obstructive pulmonary disease (COPD) in Poland from 1999 to 2014

Dziankowska-Zaborszczyk

Bryła

Ciabiada-Bryła

et al. 2019

PLoS ONE

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PurposeThe aim of the study is to analyze the standard expected years of life lost (SEYLL) due to chronic obstructive pulmonary disease (COPD) in Poland from 1999 to 2014 by sex and place of residence.MethodsThe number of deaths due to chronic obstructive pulmonary disease (J40 –J44 and J47 according to ICD-10) over the period 1999 to 2014 was analyzed based on data obtained from the Central Statistical Office in Poland. Standard expected years of life lost due to chronic obstructive pulmonary disease were calculated by sex and place of residence according to the living population (SEYLLp) and the number of deaths caused by the disease (SEYLLd). Changes in the calculated measures were evaluated using joinpoint models. The annual percentage change (APC) and the average annual percentage change (AAPC) were also calculated.ResultsThe study revealed that COPD contributed to 1.8% of the total number of deaths which occurred between 1999 and 2014. The greatest decrease in the analyzed measures was observed among males from rural areas (p<0.05) (SEYLL: AAPC = -1.6; 95%CI: -3.0;-0.2; SEYLLp: AAPC = -2.0; 95%CI: -3.4;-0.6; SEYLLd: AAPC = -1.1; 95%CI: -1.2;-0.9). A statistically significant increase in the SEYLL and SEYLLp indices was observed among female city dwellers (SEYLL: AAPC = 2.4; 95%CI:0.7;4.0 and SEYLLp: AAPC = 2.4; 95%CI: 0.8;4.1).ConclusionsAll studied measures were higher in the male group than in the female group, regardless of the place of residence. A male who died of COPD in Poland in 2014 potentially lost 14.9 years of life, whereas a female lost 14.2 years.

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Section: Introductionmentioning

confidence: 99%

Standard expected years of life lost (SEYLL) due to chronic obstructive pulmonary disease (COPD) in Poland from 1999 to 2014

Dziankowska-Zaborszczyk

Bryła

Ciabiada-Bryła

et al. 2019

PLoS ONE

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“…A worsening prognosis, multiple comorbidities, and readmission contribute to depression in patients with chronic diseases such as chronic obstructive pulmonary disease (COPD) [ 2 , 3 ]. In addition, asthma is associated with depression in elderly people [ 4 ]. Therefore, recent studies have extensively investigated the relationship of depression with asthma and COPD.…”

Section: Introductionmentioning

confidence: 99%

The relationship of depression in asthma–chronic obstructive pulmonary disease overlap syndrome

Yeh¹,

Lin²,

Hsu³

et al. 2017

PLoS ONE

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PurposeTo clarify the relationship between asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS) and depression.MethodsWe identified 10,911 patients who received an ACOS diagnosis and concurrent treatment between January 2000 and December 2009. Subjects without ACOS were included in the non-ACOS cohort (n = 10,911). Cox proportional hazard regression analysis was performed to compare the risk of depression between the ACOS and non-ACOS cohorts.ResultsThe risk of depression was higher in the ACOS cohort than in the non-ACOS cohort (adjusted hazard ratios (aHRs) = 1.67, 95% confidence interval [CI] = 1.48–1.88). In the ACOS cohort, the aHRs for depression were [2.44 (95% CI = 1.45–4.11); 2.36 (95% CI = 1.58–3.52)] in patients [aged 20–39 years; without comorbidity]. In the ACOS cohort, the aHRs for depression were 1.70 (95% CI = 1.51–1.93) and 1.84 (95% CI = 1.55–2.19) in patients without inhaled corticosteroids (ICSs) and oral steroids (OSs) use, respectively. Moreover, the aHRs for the risk of depression were 1.16 (95% CI = 0.95–1.41) and 1.12 (95% CI = 0.96–1.29) in patients with ICSs and OSs use, respectively.ConclusionThe risk of depression is higher in ACOS patients, even in those without comorbidities or in young adults. The events of the depression were not significant difference in patients receiving the ICSs/OSs between the ACOS and the non-ACOS cohorts.

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“…The hypoxemia status causes the systemic inflammation, associated [ 9 ] with Interferon gamma (IFNγ), the tumor necrosis factor-alpha (TNF-α) [ 10 ], and oxidative stress [ 11 ] leading to direct neuronal damage, as well as depletion of neurotransmitters because of the dysfunction of oxygen-dependent enzymes in chronic obstructive pulmonary disease (COPD) [ 12 ]. ACOS [ 13 ] is the concurrent occurrence of asthma [ 9 ] and COPD [ 14 ]. The high frequency of ACOS [ 15 ] with exacerbation aggravate systemic inflammation [ 12 ] and hypoxemia [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…The high frequency of ACOS [ 15 ] with exacerbation aggravate systemic inflammation [ 12 ] and hypoxemia [ 16 ]. Therefore, the patients with ACOS may be associated with the neurodegenerative diseases [ 9 , 16 , 17 ], especially these patients of asthma or COPD with exacerbation [ 18 ] and deterioration of hypoxemia [ 17 – 19 ]. This speculation didn’t examined in detail up to today in English literature.…”

Section: Introductionmentioning

confidence: 99%

Effect of the asthma-chronic obstructive pulmonary disease syndrome on the stroke, Parkinson's disease, and dementia: a national cohort study

et al. 2017

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BackgroundTo evaluate the association of asthma–chronic obstructive pulmonary disease syndrome (ACOS) with neurodegenerative diseases (stroke, Parkinson's disease and dementia) and the role of the steroids in the neurodegenerative diseases among the ACOS cohort.Materials and MethodsComparison of the ACOS cohort (N = 10,260) with the non-ACOS cohort (n = 20,513) based on the patients aged ≧40 years in the National Health Insurance Research Database from January 1, 2000 to December 31, 2010. These patients follow up to diagnosis of neurodegenerative diseases or the December 31, 2011; using multivariable Cox proportional hazards models.ResultsAfter adjustment for potential confounders, the [adjusted hazard ratio (aHR), 95% confidence interval (CI)] in the ACOS cohort were [1.39, 1.28–1.50] [1.56, 1.34–1.81] and [1.43, 1.29–1.59] for stroke, Parkinson's disease, dementia; respectively. The [aHR, 95% CI] for ACOS cohort with (inhaler corticosteroids ≧0.13 gram/ oral steroids ≧0.08gram) were with less risk (all aHR<1, p values <0.05) for these 3 neurodegenerative diseases except Parkinson's disease with inhaler corticosteroids >0.43 gram. The risk of stroke and dementia were the lower in patients with < 250 μg/d of a fluticasone equivalent inhaler corticosteroids (aHR = 0.53, 95% CI = 0.35–0.79; aHR = 0.53, 95% CI = 0.31–0.90, respectively).ConclusionsThe ACOS cohort had a higher risk of the neurodegenerative diseases. The lower dose of the inhaler corticosteroids with cumulative dose ≧0.13 gram have the less risk of stroke and dementia.

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Asthma, COPD and comorbidities in elderly people

Abstract: Asthma coexisted frequently with arterial hypertension and depression in elderly patients. Patients with COPD have a more exaggerated profile of coexisting diseases, specifically cardiovascular problems.

Cited by 26 publications

References 17 publications

Standard expected years of life lost (SEYLL) due to chronic obstructive pulmonary disease (COPD) in Poland from 1999 to 2014

Standard expected years of life lost (SEYLL) due to chronic obstructive pulmonary disease (COPD) in Poland from 1999 to 2014

The relationship of depression in asthma–chronic obstructive pulmonary disease overlap syndrome

Effect of the asthma-chronic obstructive pulmonary disease syndrome on the stroke, Parkinson's disease, and dementia: a national cohort study

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