Asthma definitions, relative validity and impact on known risk factors in young Brazilians

Vianna, Elcio Oliveira; Garcia, Clécia Aparecida; Bettiol, Heloísa; Barbieri, Marco Antônio; Rona, Roberto J.

doi:10.1111/j.1398-9995.2007.01467.x

Cited by 14 publications

(22 citation statements)

References 19 publications

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“…An advantage of the present study was the identification of BHR by bronchial challenge test with mannitol, an indirect stimulation agent . The diagnosis of asthma based on positive BHR and symptoms has been seen as a gold standard definition of asthma . For instance, we found 42 asthmatic subjects.…”

Section: Discussionmentioning

confidence: 91%

Allergic sensitization to laboratory animals is more associated with asthma, rhinitis, and skin symptoms than sensitization to common allergens

Simoneti

Ferraz

Menezes

et al. 2017

Clin Experimental Allergy

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Section: Discussionmentioning

confidence: 91%

Allergic sensitization to laboratory animals is more associated with asthma, rhinitis, and skin symptoms than sensitization to common allergens

Simoneti

Ferraz

Menezes

et al. 2017

Clin Experimental Allergy

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“…Therefore, we selected 20% as a possible prevalence of asthma in laboratory animal workers (18). In previous studies by our group, we described a prevalence of asthma in the general population of approximately 10% (19). …”

Section: Methodsmentioning

confidence: 91%

Laboratory animals and respiratory allergies: The prevalence of allergies among laboratory animal workers and the need for prophylaxis

Ferraz¹,

Arruda²,

Bagatin³

et al. 2013

Clinics

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OBJECTIVE:Subjects exposed to laboratory animals are at a heightened risk of developing respiratory and allergic diseases. These diseases can be prevented by simple measures such as the use of personal protective equipment. We report here the primary findings of the Laboratory Animals and Respiratory Allergies Study regarding the prevalence of allergic diseases among laboratory animal workers, the routine use of preventive measures in laboratories and animal facilities, and the need for prevention programs.METHODS:Animal handlers and non-animal handlers from 2 Brazilian universities (University of São Paulo and State University of Campinas) answered specific questionnaires to assess work conditions and symptoms. These subjects also underwent spirometry, a bronchial challenge test with mannitol, and skin prick tests for 11 common allergens and 5 occupational allergens (rat, mouse, guinea pig, hamster, and rabbit).RESULTS:Four hundred fifty-five animal handlers (32±10 years old [mean±SD], 209 men) and 387 non-animal handlers (33±11 years old, 121 men) were evaluated. Sensitization to occupational allergens was higher among animal handlers (16%) than non-animal handlers (3%, p<0.01). Accessibility to personal protective equipment was measured at 85% (median, considering 73 workplaces of the animal handler group). Nineteen percent of the animal handlers indicated that they wear a respirator at all times while handling animals or working in the animal room, and only 25% of the animal handlers had received an orientation about animal-induced allergies, asthma, or rhinitis.CONCLUSION:In conclusion, our data indicate that preventive programs are necessary. We suggest providing individual advice to workers associated with institutional programs to promote a safer work environment.

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“…As reações cutâneas a cada alérgeno testado foram registradas depois de 15 min como a média entre o diâmetro máximo da pápula e o diâmetro perpendicular ao máximo. Foram considerados atópicos os indivíduos com reação papular ≥ 3 mm para um ou mais dos oito alérgenos testados 19 . Os testes e medições foram realizados no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, e adotaram-se procedimentos rigorosos de segurança em todas as etapas do estudo 20 .…”

Section: Figura 1 -Base De Amostragem Da Coorte De Nascimento De 1978unclassified

Atopy risk factors at birth and in adulthood

Ferraz¹,

Garcia²,

Bettiol³

et al. 2011

J Pediatr (Rio J)

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Objective: To study the association between atopy and variables such as weight, length, and socioeconomic level at birth and in young adulthood.Methods: A total of 2,063 subjects were investigated in a prospective birth cohort study of individuals born in Ribeirão Preto, Brazil, in 1978Brazil, in /1979, and examined at the age of 23-25 years. Skin prick tests (SPT) for eight common allergens in Brazil were performed. Subjects with a wheal reaction ≥ 3 mm to one or more of the eight allergens tested were considered to be atopic. We used the log-binomial model (generalized linear model) in order to assess the association between atopy and birth or adult variables. Results:The prevalence of positive SPT was 47.6%. Male gender was associated with an increased risk of atopy (relative risk [RR] = 1.18; 95% confidence interval [95%CI] 1.07-1.30). Low level of schooling was a protective factor against atopy, with a RR = 0.74; 95%CI 0.62-0.89. Living with a smoker in childhood was also associated with lower risk of atopy (RR = 0.87; 95%CI 0.79-0.96). Birth weight, length and order, maternal age, and intrauterine growth restriction were not associated with positive SPT. Conclusions:This study showed that male gender was associated with an increased risk of atopy. Low socioeconomic status, assessed by low level of schooling, was a protective factor against atopy. These data agree with the hygiene hypothesis.J Pediatr (Rio J). 2011;87(4):336-342: Allergens, allergy, risk factors, skin test. ResumoObjetivo: Estudar a associação entre atopia e variáveis como peso, comprimento e nível socioeconômico no nascimento e na idade adulta jovem. Métodos:Foram investigados 2.063 indivíduos em um estudo prospectivo de coorte de nascimento com indivíduos nascidos em Ribeirão Preto (SP), em 1978/1979, e examinados aos 23-25 anos de idade. Realizaram-se testes cutâneos de puntura (TCP) para oito alérgenos comuns no Brasil. Foram considerados atópicos os indivíduos que apresentaram reação papular ≥ 3 mm para um ou mais dos oito alérgenos testados. A fim de avaliar a associação entre atopia e variáveis no nascimento e na idade adulta, utilizamos o modelo log-binomial (modelo linear generalizado).Resultados: A prevalência de TCP positivo foi de 47,6%. O gênero masculino esteve associado a aumento do risco de atopia [risco relativo (RR) = 1,18; intervalo de confiança de 95% (IC95%) 1,07-1,30]. O baixo nível de escolaridade foi um fator de proteção contra atopia, com um RR = 0,74; IC95% 0,62-0,89. A convivência com um fumante na infân-cia também esteve associada a um menor risco de atopia (RR = 0,87; IC95% 0,79-0,96). Peso e comprimento ao nascer, ordem de nascimento, idade materna e restrição de crescimento intrauterino não estiveram associados a TPC positivo. Conclusões:Este estudo demonstrou que o gênero masculino esteve associado a um aumento do risco de atopia. O baixo nível socioeconômico, estabelecido pelo baixo nível de escolaridade, foi um fator de proteção contra a atopia. Esses dados estão de acordo com a teoria da higiene...

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Asthma definitions, relative validity and impact on known risk factors in young Brazilians

Abstract: Our study provided little support for a greater validity of this asthma score over other asthma definitions, and only marginal advantage for identifying risk factors.

Cited by 14 publications

References 19 publications

Allergic sensitization to laboratory animals is more associated with asthma, rhinitis, and skin symptoms than sensitization to common allergens

Allergic sensitization to laboratory animals is more associated with asthma, rhinitis, and skin symptoms than sensitization to common allergens

Laboratory animals and respiratory allergies: The prevalence of allergies among laboratory animal workers and the need for prophylaxis

Atopy risk factors at birth and in adulthood

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