Asthma-like Features and Clinical Course of Chronic Obstructive Pulmonary Disease. An Analysis from the Hokkaido COPD Cohort Study

Suzuki, Masaru; Makita, Hironi; Konno, Satoshi; Shimizu, Kaoruko; Kimura, Hironobu; Kimura, Hirokazu; Nishimura, Masaharu

doi:10.1164/rccm.201602-0353oc

Cited by 130 publications

(124 citation statements)

References 32 publications

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“…Similar results were found in a study of 137 patients with COPD hospitalized in Italy . Studying the effect of asthma‐like features on the clinical course of COPD in Japan, Suzuki et al also found that blood eosinophils <300 cells/μL was associated with a significantly faster decline in post‐bronchodilator FEV1 . With regard to pulmonary infections, it has been suggested that in COPD, a low eosinophil count correlated with more frequent bacterial infections and a higher bacterial load of Haemophilus influenzae , Moraxella catarrhalis and Streptococcus pneumoniae .…”

Section: Discussionsupporting

confidence: 65%

“…17 Studying the effect of asthma-like features on the clinical course of COPD in Japan, Suzuki et al also found that blood eosinophils <300 cells/lL was associated with a significantly faster decline in post-bronchodilator FEV1. 35 With regard to pulmonary infections, it has been suggested that in COPD, a low eosinophil count correlated with more frequent bacterial infections and a higher bacterial load of Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae. Furthermore, there are several reports that high blood eosinophil count in COPD is associated with better response to corticosteroid therapy.…”

Section: Discussionmentioning

confidence: 99%

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Blood biomarkers as predictors of long‐term mortality in COPD

Mendy

Forno

Niyonsenga

et al. 2018

Clinical Respiratory J

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Blood biomarkers as predictors of long‐term mortality in COPD

Mendy

Forno

Niyonsenga

et al. 2018

Clinical Respiratory J

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“…Previous reports have consistently found that the BMI of Asian patients is lower than that of Western patients. [25][26][27][28] Adverse effects of COPD drugs can occur because of differences in BMI.…”

Section: Body Mass Indexmentioning

confidence: 99%

Management of COPD in Asia: A position statement of the Asian Pacific Society of Respirology

et al. 2019

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Chronic obstructive pulmonary disease (COPD) is a major disease in Asia. However, how to manage specifically Asian COPD patients has not been proposed. Awareness of COPD is very low and underdiagnosis/undertreatment is common in Asian countries. Low utilization of pulmonary function test and inhalers is also a problem. Moreover, high smoking prevalence and air pollution are barriers to managing Asian patients with COPD. The relatively low body mass index of Asian patients with COPD can increase their risk for experiencing adverse effects from COPD drugs. Physicians should consider the unique features of Asian populations with COPD such as the high prevalence rates of bronchiectasis and tuberculosis‐destroyed lungs, biomass smoke exposure and parasitic infection.

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“…The influence of ACOS defining criteria on prognosis was highlighted by Suzuki et al who investigated how asthma-like features influenced the clinical course of patients with COPD after excluding those with physician diagnosed asthma (21). Within this 10-year Japanese multicentre observational study, neither bronchodilator reversibility, blood eosinophilia or atopy were associated with worse clinical outcome.…”

Section: Asthma-copd Overlapmentioning

confidence: 99%