Asthma-related comorbidities

Boulet, Louis‐Philippe; Boulay, Marie‐Ève

doi:10.1586/ers.11.34

Cited by 226 publications

(172 citation statements)

References 196 publications

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“…To obtain less confounded estimates, we adjusted the analyses for several potential predictors of child health that might confound or suppress effects, selected a priori, including socioeconomic status 31 based on the mother' s occupation (see ref 32), parity, 33 maternal age, 34 general maternal health, to account for potential comorbid conditions that are frequently observed in asthma patients, 35,36 smoking, 37 and infant gender, 38,39 with the categories indicated in Table 1. We obtained information on offspring gender and maternal age at delivery from the Danish Medical Birth Registry, 40 and on socioeconomic status, parity, smoking during pregnancy, and general maternal health from the interviews taken at 12 and 30 weeks' gestation and at 6 months postpartum.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…35 Indeed, if conditions such as psychopathologies are present during pregnancy, the offspring is at increased risk of adverse health outcomes. 64 However, comorbidities may well be mediators of the observed associations, meaning that, in this case, comorbidities are only triggered by asthma, and adjusting for mediators bears the risk of underestimation.…”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Asthma During Pregnancy and Clinical Outcomes in Offspring: A National Cohort Study

Tegethoff¹,

Olsen

Schaffner

et al. 2013

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Asthma is a common medical complication during pregnancy that is associated with an increased risk of adverse obstetric outcomes. WHAT THIS STUDY ADDS:This study adds knowledge on potential long-term consequences of maternal asthma during pregnancy for offspring health, demonstrating that maternal asthma during pregnancy is linked to a wide spectrum of offspring diseases during childhood. abstract BACKGROUND AND OBJECTIVE: Maternal asthma is a common pregnancy complication, with adverse short-term effects for the offspring. The objective was to determine whether asthma during pregnancy is a risk factor of offspring diseases. METHODS:We studied pregnant women from the Danish National Birth Cohort (births: 1996Cohort (births: -2002; prospective data) giving birth to live singletons (n = 66 712 mother-child pairs), with 4145 (6.2%) women suffering from asthma during pregnancy. We estimated the associations between asthma during pregnancy and offspring diseases (International Classification of Diseases, 10th Revision diagnoses from national registries), controlling for potential confounders and validating findings by secondary analyses. RESULTS:Offspring median age at end of follow-up was 6.2 (3.6-8.9) years. Asthma was associated with an increased offspring risk of infectious and parasitic diseases (hazard ratio [HR] 1.34; 95% confidence interval [CI] 1.23-1.46), diseases of the nervous system (HR 1.43; CI 1.18-1.73), ear (HR 1.33; CI 1.19-1.48), respiratory system (HR 1.43; CI 1.34-1.52), and skin (HR 1.39; CI 1.20-1.60), and potentially (not confirmed in secondary analyses) of endocrine and metabolic disorders (HR 1.26; CI 1.02-1.55), diseases of the digestive system (HR 1.17; CI 1.04-1.32), and malformations (odds ratio 1.13; CI 1.01-1.26), but not of neoplasms, mental disorders, or diseases of the blood and immune system, circulatory system, musculoskeletal system, and genitourinary system. CONCLUSIONS:To the best of our knowledge, this is the first comprehensive study of the associations between asthma during pregnancy and a wide spectrum of offspring diseases. In line with previous data on selected outcomes, asthma during pregnancy may be a risk factor for numerous offspring diseases, suggesting that careful monitoring of women with asthma during pregnancy and their offspring is important. Dr Tegethoff conceptualized and designed the study, carried out the statistical analyses, interpreted data, drafted the initial manuscript, critically reviewed the manuscript, and obtained funding; Dr Olsen acquired data, interpreted data, critically reviewed the manuscript, and obtained funding; Mr Schaffner carried out the statistical analyses, interpreted data, and critically reviewed the manuscript; Dr Meinlschmidt conceptualized and designed the study, carried out the statistical analyses, interpreted data, critically reviewed the manuscript, and obtained funding; and all authors approved the final manuscript as submitted. Asthma is a frequently occurring medical condition in pregnancy, ...

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Section: Statistical Analysesmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Asthma During Pregnancy and Clinical Outcomes in Offspring: A National Cohort Study

Tegethoff¹,

Olsen

Schaffner

et al. 2013

Pediatrics

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“…Asthma is a chronic inflammatory respiratory disease and is associated with various morbidities 1 and high medical costs. 2 A common misconception is that asthma occurs only in childhood.…”

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confidence: 99%

Effect of Continuity of Care on Emergency Department Visits in Elderly Patients with Asthma in Taiwan

Kao¹,

Wu²

2017

J Am Board Fam Med

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Background: Continuity of care (COC) is positively associated with health care outcomes. However, the effect of COC on the reduction of asthma-related emergency department (ED) visits among older asthmatic patients is not clearly understood.Methods: We conducted a retrospective cohort study using the Taiwan Results: Among a total of 3395 subjects, the overall mean COC was 0.73, and 48.5% of subjects had perfect COC (COCI ‫؍‬ 1). After controlling for covariables, in the group of patients with low COC, the risk of having an asthma-related ED visit was higher compared with those with perfect COC (Adjusted HR, 2.11; 95% CI, 1.37؊3.25).Conclusions

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“…5 For AX, the following comorbidities were chosen: sinusitis, gastroesophageal reflux disease, depression, anxiety, and obesity (ICD-9-CM 473, 530.81, 296.2x, 296.3x, 311, 300, 278). 10,11 These comorbidities (and rhinitis) were some of the most commonly reported comorbidities of AX, especially childhood AX. AR and AX were not counted as comorbidities of each other.…”

Section: Impact Of a Prior Authorization Policy For Montelukast On CLmentioning

confidence: 99%

Impact of a Prior Authorization Policy for Montelukast on Clinical Outcomes for Asthma and Allergic Rhinitis Among Children and Adolescents in a State Medicaid Program

Keast¹,

Thompson²,

Farmer³

et al. 2014

JMCP

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T he use of prior authorizations (PA) by state Medicaid policymakers, as a strategy to help control drug expenditures, has been widely researched over the past 2 decades. However, continuous review of the strategy is necessary, particularly in Medicaid populations, to ensure that best practices are applied and that the most cost-effective use of resources is achieved. The review of PA policies in Medicaid has often focused on costs associated with newly implemented restrictions, but policymakers should also review these policies for the occurrence of unintended clinical consequences. Public policymakers often struggle with increased membership and limited budgets. Restrictions, commonly in the form of prior authorizations, are often placed on more costly pharmaceuticals, especially when lower cost or more effective products are available. Restrictions placed on products for difficult-to-manage disease states must be reviewed in order to ensure that unintended clinical consequences do not occur.

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Asthma-related comorbidities

Cited by 226 publications

References 196 publications

Asthma During Pregnancy and Clinical Outcomes in Offspring: A National Cohort Study

Asthma During Pregnancy and Clinical Outcomes in Offspring: A National Cohort Study

Effect of Continuity of Care on Emergency Department Visits in Elderly Patients with Asthma in Taiwan

Impact of a Prior Authorization Policy for Montelukast on Clinical Outcomes for Asthma and Allergic Rhinitis Among Children and Adolescents in a State Medicaid Program

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