Asthma severity and impact on perinatal outcomes: an updated systematic review and meta‐analysis

Xu, Zhiwei; Doust, Jenny; Wilson, Louise F.; Dobson, Annette; Dharmage, Shyamali C.; Mishra, Gita D.

doi:10.1111/1471-0528.16968

Cited by 15 publications

(9 citation statements)

References 48 publications

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“…25 In the first trimester, corticosteroids may increase the risk of fetal orofacial cleft, 26 and when administered in the third trimester, associations with low birth weight and reduced head circumference of the baby have been noted. 27,28 On the other hand, the benefits of corticosteroids are considered more important than the rare side effects found in other diseases, for example, severe asthma, 29 or when fetal lung maturation must be accelerated in preterm deliveries. 30 No effect of corticosteroid treatment on the remission of Bell's palsy in pregnant women was seen.…”

Section: Discussionmentioning

confidence: 99%

Bell's Palsy in Pregnancy and Postpartum: A Retrospective Case‐Control Study of 182 Patients

Lansing

Wendel

Hultcrantz

et al. 2023

Otolaryngol.--head neck surg.

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Objective To assess the incidence of Bell's palsy in pregnant and postpartum women. Additionally, to compare facial outcomes in terms of Sunnybrook score following Bell's palsy with regard to corticosteroid treatment and other confounding factors. Study Design Retrospective case‐control study. Setting University Hospital, Stockholm, Sweden. Methods All women with Bell's palsy in pregnancy or postpartum (6 weeks after birth) with a computerized medical chart in the Stockholm Region 2005 to 2015 were included. The total number of births in the region during this period was retrieved from the Swedish Medical Birth Register. Nonpregnant age‐matched women with Bell's palsy served as controls. Characteristics, medication, and Sunnybrook scores were collected. Risk factors for incomplete recovery (Sunnybrook score <96) at 3 months were calculated by logistic regression. Results In total, 182 pregnant and postpartum women with Bell's palsy were identified. The estimated incidence among pregnant and postpartum women was 60.5/100,000 person‐years. The mean Sunnybrook score at 3 months was 74 among pregnant and postpartum women and 83 for controls (p = .002). At 12 months, Sunnybrook score was 81 and 89, respectively (p = .017). Only one‐third of the pregnant women received corticosteroid treatment. Conclusion The incidence of Bell's palsy in pregnancy and postpartum was 60.5 per 100,000 women and year in the Stockholm Region. Sunnybrook score was poorer in pregnant women compared with postpartum and nonpregnant women throughout. Corticosteroid treatment had little effect on any patients, however, only one‐third of the pregnant women received this treatment.

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Section: Discussionmentioning

confidence: 99%

Bell's Palsy in Pregnancy and Postpartum: A Retrospective Case‐Control Study of 182 Patients

Lansing

Wendel

Hultcrantz

et al. 2023

Otolaryngol.--head neck surg.

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“…Recent research suggests that degree of asthma severity is associated with poorer outcomes for the offspring. A meta-analysis by Xu and colleagues found that pregnant women with an asthma exacerbation had an increased risk of delivering low birth weight (LBW) babies and small-for-gestational age (SGA) babies, compared with pregnant women with asthma but without an exacerbation [pooled adjusted odds ratio (OR): 1.15, 95% CI 1.02–1.29 for LBW; number of studies with adjusted OR: 3; I 2 = 0%] (pooled adjusted OR: 1.13, 95% CI 1.04–1.23 for SGA; number of studies with adjusted OR: 4; I 2 = 0%) and compared with pregnant women without asthma [23 ▪▪ ].…”

Section: Management Of Severe Asthma In Pregnancymentioning

confidence: 99%

Asthma in pregnancy: a review of recent literature

Colas,

Namazy

2024

Current Opinion in Pulmonary Medicine

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Purpose of review Asthma remains the most common respiratory disease in pregnancy. Identifying risk factors for asthma exacerbations during pregnancy is critical, as uncontrolled asthma can have detrimental effects for both mother and baby. In this review, we discuss recent literature exploring risk factors, fetal and maternal effects, and treatment options for asthma during pregnancy. Recent findings Recent literature suggests that optimizing asthma during pregnancy improves outcomes for both mother and baby, as well as later in childhood. Current research affirms that the benefit of asthma medication use outweighs any potential risks related to the medications themselves. Limited information is available regarding the use of newer therapies such as biologics during pregnancy. Summary Identifying risk factors for asthma exacerbations during pregnancy is critical to prevent adverse outcomes for both mother and baby. Recent evidence continues to affirm the safety of asthma medication use; more studies are needed regarding the use of new therapies during pregnancy.

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“…Asthma during pregnancy is a significant public health issue because it is one of the most potentially serious medical problems to complicate pregnancy. Studies have shown that having asthma during pregnancy puts both mother and baby at risk for complications 1 .…”

Section: Introductionmentioning

confidence: 99%