Astragalosides attenuate learning and memory impairment in rats following ischemia-reperfusion injury

Abstract

Abstract. Astragalosides (ASTs) have been traditionally used in the treatment of various cardiovascular and cerebrovascular diseases. The aim of the present study was to investigate the neuroprotective effects of AST on learning and memory following focal cerebral ischemia/reperfusion in a rat model. A Morris water maze was used to measure the effect of AST on learning and memory impairments. A histological examination and Hoechst 33258 staining was used to observe the neuronal changes and apoptosis in the hippocampus. The activity of phospho-extracellular signal-regulated kinases

Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion

“…It is well known that cerebral hypoperfusion is a common physiopathological condition contributing to neurodegenerative diseases including VaD ( 29 ). Therefore, a rat model of VaD was successfully induced in the present study by repeated occlusion of the common carotid artery followed by reperfusion, which resulted in memory impairment, which was in accordance with the results of previous studies ( 20 , 21 ). Administration of YXJF significantly alleviated memory impairment in the model rats to a similar extent to that of the treatment with huperzine A and piracetam, the two currently used anti-dementia drugs ( 30 , 31 ), in agreement with the previous study by our group ( 18 ).…”

“…After 1 week of acclimatization, the rats were subjected to the Morris water maze test to ensure their normal memory. Then, a rat model of VaD was induced by repeated occlusion of the common carotid artery followed by reperfusion, as previously described, with certain modifications ( 20 , 21 ). Briefly, the animals were randomly divided into sham-operated and operated groups.…”

Global Gene Expression Profile of the Hippocampus in a Rat Model of Vascular Dementia

“…Increasing evidence (de la Torre 2012; Ihara et al 2014) indicates that cerebral hypoperfusion is the key pathophysiological basis of VD, but how global genes in hippocampus respond to cerebral ischemia-reperfusion keeps fully unclear. In this study, cerebral ischemia-reperfusion in rats was induced by repeated, transient occlusion of bilateral common carotid arteries followed by reperfusion, thus causing rats deficit of memory and cognitive function and histopathological changes in hippocampus, which was similar to the previous reports (Alipanahzadeh et al 2014;Wu et al 2014).…”

“…Rat model with VD was induced by repeated occlusion of common carotid arteries followed by reperfusion as previously described procedure with some modifications (Alipanahzadeh et al 2014;Wu et al 2014). Briefly, the rats were randomly divided into the shamoperated (SHAM) and the operated (OPER) groups.…”

Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage

“…A variety of tests are available for evaluation of neurobehavioral function, such as Long׳s test 33 , 43 , 93 , Morris water maze test 17 , 19 , 110 , 111 , 112 , eight-arm radical maze test 29 , 113 , step down and step through test 40 , 53 , beam-walking test 42 , forced swimming test and tail suspension test 103 . Using these tests, many TCM preparations, Chinese materia medica and active compounds have been shown to alleviate neurological deficits and improve learning and memory after I/R injury.…”