Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice

Tian, Qing-E; Huan-de, LI; Yan, Miao; Cai, Hualin; Tan, Qin-You; Zhang, Wenyuan

doi:10.3748/wjg.v18.i47.7079

Cited by 80 publications

(49 citation statements)

References 28 publications

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“…In addition, it was reported that long-term treatment of genistein could induce the related protein expression of first-pass metabolism in mice [14,15] and the activities of phase II metabolic enzymes in mice could be mediated by oligosaccharides [13,16,17]. Moreover, some non-digestible carbohydrates, such as hyaluronan oligosaccharides and astragalus polysaccharides, were shown to inhibit P-gp, MRP1, and MRP2 expression, thereby contributing to an increase in intracellular concentration of food ingredients or drugs [18,19]. Accordingly, we suppose that stachyose promoting absorption of genistein may be closely related to inhibition of first-pass metabolism of genistein in the small intestine.…”

Section: Introductionmentioning

confidence: 99%

Non-digestible stachyose promotes bioavailability of genistein through inhibiting intestinal degradation and first-pass metabolism of genistein in mice

Lin

et al. 2017

Food & Nutrition Research

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This study was designed to explore the molecular mechanism of stachyose in enhancing the gastrointestinal stability and absorption of soybean genistein in mice. Male Kunming mice in each group (n = 8) were administered by intragastric gavage with saline, stachyose (250 mg/kg·bw), genistein (100 mg/kg·bw), and stachyose (50, 250, and 500 mg/kg·bw) together with genistein (100 mg/kg·bw) for 4 consecutive weeks, respectively, and then their urine, feces, blood, gut, and liver were collected. UPLC-qTOF/MS analysis showed that levels of genistein and its metabolites (dihydrogenistein, genistein 7-sulfate sodium salt, genistein 4’-β-D-glucuronide, and genistein 7-β-D-glucuronide) in serum and urine were increased with an increase in stachyose dosages in mice. Furthermore, the feces level of genistein aglycone was also elevated by co-treatment of stachyose with genistein. However, the feces concentration of dihydrogenistein, a characteristic metabolite of genistein by gut microorganism, was decreased by stachyose administration in a dose-dependent manner. Additionally, the simultaneous administration with stachyose and genistein in mice could decrease intestinal SULT, UGT, P-gp, and MRP1 expression, relative to the treatment with individual stachyose or genistein. These results demonstrate that stachyose-mediated inhibition against the intestinal degradation of genistein and expression of phase II enzymes and efflux transporters can largely contribute to the elevated bioavailability of soybean genistein.

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Section: Introductionmentioning

confidence: 99%

Non-digestible stachyose promotes bioavailability of genistein through inhibiting intestinal degradation and first-pass metabolism of genistein in mice

Lin

et al. 2017

Food & Nutrition Research

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“…To seek effective herbs or herbal components to reverse drug resistance has become one of research focuses in liver cancer study. Astragalus polysaccharides have been reported to be potent to enhance antitumor effects of adriamycin in H22 hepatocarcinoma by upregulating IL1α, IL2, IL6, and TNFα, downregulating IL10 and multidrug resistance protein 1 (MDR1) [199] . Astragaloside Ⅱ, another component from HuangQi (Astragalus membranaceus), is effective to increase 5Fu cytotoxicity toward 5Fu resistant Bel7402/Fu cells accompanied by down regulation of Pgp (Pglycoprotein), phosphorylation of ERK1/2, p38 and JNK [200] .…”

Section: Reversal Of Drug Resistancementioning

confidence: 99%

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Wang

2015

WJH

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and other TCM syndromes (Zheng). Modern treatments such as surgery, transarterial chemoembolization (TACE) and high intensity focus ultrasound treatment would influence the manifestation of TCM syndromes. Herbs with traditional efficacy of tonifying Qi, blood and Yin, soothing liver-Qi stagnation, clearing heat and detoxifying and dissolving stasis, have been demonstrated to be potent to prevent hepatocarcinogenesis. TCM has been widely used in all aspects of integrative therapy in hepatocarcinoma, including surgical resection, liver transplantation, TACE, local ablative therapies and even as monotherapy for middle-advanced stage hepatocarcinoma. Clinical practices have confirmed that TCM is effective to alleviate clinical symptoms, improve quality of life and immune function, prevent recurrence and metastasis, delay tumor progression, and prolong survival time in hepatocarcinoma patients. The effective mechanism of TCM against hepatocarcinoma is related to inducing apoptosis, autophagy, anoikis and cell senescence, arresting cell cycle, regulating immune function, inhibiting metastasis and angiogenesis, reversing drug resistance and enhancing effects of chemotherapy. Along with the progress of research in this field, TCM will contribute more to the prevention and treatment of hepatocarcinoma. AbstractTraditional Chinese medicine (TCM) has played a positive role in the management of hepatocarcinoma. Hepatocarcinoma patients may present Qi-stagnation, damp-heat, blood stasis, Qi-deficiency, Yin-deficiency REVIEWSubmit a

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“…Among these, Astragalus polysaccharides (APS) has been most extensively studied, which is demonstrated to have substantial pharmacological applications, including anti-cancer, anti-inflammatory, immunomodulatory and antioxidant effects. APS plays its affiliated anticancer role by strengthening immune function (Liu et al, 2010;Zhao et al, 2011), counteracting the negative effects of chemotherapeutic drugs and enhancing the sensitivity of chemotherapeutics (Tian et al, 2012).…”

Section: Protective Effect Of Astragalus Polysaccharides On Liver Injmentioning

confidence: 99%

Protective Effect of Astragalus polysaccharides on Liver Injury Induced by Several Different Chemotherapeutics in Mice

Liu

Gao²,

Li³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice

Abstract: APS exerts a synergistic anti-tumor effect with ADM in H22 tumor-bearing mice. This may be related to its ability to enhance the expression of IL-1α, IL-2, IL-6, and TNF-α, decrease IL-10, and down-regulate MDR1 mRNA and P-GP expression levels.

Cited by 80 publications

References 28 publications

Non-digestible stachyose promotes bioavailability of genistein through inhibiting intestinal degradation and first-pass metabolism of genistein in mice

Non-digestible stachyose promotes bioavailability of genistein through inhibiting intestinal degradation and first-pass metabolism of genistein in mice

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Protective Effect of Astragalus polysaccharides on Liver Injury Induced by Several Different Chemotherapeutics in Mice

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