Astrocaryum aculeatum fruit improves inflammation and redox balance in phytohemagglutinin-stimulated macrophages

Cabral, Fernanda Licker; Bernardes, Viviane M.; Passos, Daniela F.; Oliveira, Juliana Sorraila de; Doleski, Pedro H.; Silveira, Karine; Horvarth, Mauren C.; Bremm, João M.; Barbisan, Fernanda; Azzolin, Verônica Farina; Teixeira, Cibele Ferreira; Andrade, Cínthia Melazzo de; Cruz, Ivana Beatrice Mânica da; Ribeiro, Euler Esteves

doi:10.1016/j.jep.2019.112274

Cited by 24 publications

(18 citation statements)

References 32 publications

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“…2e) quando comparados com o controle sem tratamento. Ainda, Cabral et al (2020), demostraram que extrato de tucumã inibiu a proliferação de macrófagos, aumentou as defesas antioxidantes e reduziu os níveis de estresse oxidativo, além disso, modulou genes relacionados a resposta inflamatória.…”

Section: Resultsunclassified

Efeito in vitro do extrato de Tucumã (astrocaryum aculeatum) em células mononucleares de sangue periférico

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Section: Resultsunclassified

Efeito in vitro do extrato de Tucumã (astrocaryum aculeatum) em células mononucleares de sangue periférico

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“…Polyphenols from oolong and black tea demonstrated various health benefits including anticancer, antioxidant, anti-cardiovascular, antimicrobial, anti-hyperglycemic, and anti-obesity activities [145]. Polyphenol extracts rich in β-carotene and rutin showed to have not only antioxidant but also anti-inflammatory effect [146]. Polyphenol extracts also demonstrated antimicrobial activity [144,147].…”

Section: Polyphenols As Extracted Biocompoundsmentioning

confidence: 99%

Green and Sustainable Valorization of Bioactive Phenolic Compounds from Pinus By-Products

et al. 2020

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In Europe, pine forests are one of the most extended forests formations, making pine residues and by-products an important source of compounds with high industrial interest as well as for bioenergy production. Moreover, the valorization of lumber industry residues is desirable from a circular economy perspective. Different extraction methods and solvents have been used, resulting in extracts with different constituents and consequently with different bioactivities. Recently, emerging and green technologies as ultrasounds, microwaves, supercritical fluids, pressurized liquids, and electric fields have appeared as promising tools for bioactive compounds extraction in alignment with the Green Chemistry principles. Pine extracts have attracted the researchers’ attention because of the positive bioproperties, such as anti-inflammatory, antimicrobial, anti-neurodegenerative, antitumoral, cardioprotective, etc., and potential industrial applications as functional foods, food additives as preservatives, nutraceuticals, pharmaceuticals, and cosmetics. Phenolic compounds are responsible for many of these bioactivities. However, there is not much information in the literature about the individual phenolic compounds of extracts from the pine species. The present review is about the reutilization of residues and by-products from the pine species, using ecofriendly technologies to obtain added-value bioactive compounds for industrial applications.

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“…Tucumã extract, in this study, was effective in reducing these oxidative damage markers. The antioxidant and anti-inflammatory potentials of Tucumã extract were previously demonstrated in vitro (Cabral et al, 2020) and in vivo . In hyperglycemic rats, Tucumã reduced lipid peroxidation, as well as protein carbonylation .…”

Section: Discussionmentioning

confidence: 91%

“…It suggests that oxidative stress may be contributing to cellular and functional damage. Bioactive compounds such as carotenoids and flavonoids have anti-inflammatory and antioxidant properties (Cabral et al, 2020;de Souza Filho et al, 2013). Their abundant presence in the Tucumã fruits may have prevented the detrimental effects of hyperlipidemia on the memory of the animals.…”

Section: Discussionmentioning

confidence: 99%

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Tucumã ( Astrocaryum aculeatum ) prevents memory loss and oxidative imbalance in the brain of rats with hyperlipidemia

et al. 2021

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Hyperlipidemia generates deposition of lipids, inflammation, and oxidative damage in cells and tissues, including those of the brain. Tucumã (Astrocaryum aculeatum) fruits contain bioactive compounds with antioxidant and anti-inflammatory effects. We evaluated the action of Tucumã extract on memory and brain cortex redox balance in hyperlipidemic rats. For 30 days, Wistar rats received Tucumã extract (250 mg/kg). Then, hyperlipidemia was induced by intraperitoneal administration of Poloxamer-407. Twenty-four hours later, the object recognition index was measured. The animals were euthanized for sample collection 36 hr postinduction.Hyperlipidemic animals showed memory loss and an imbalance between reactive species and intrinsic antioxidants. We found that Tucumã prevented memory loss and protein and lipid oxidative damage and prompted a better antioxidant response in the cerebral cortex of rats with hyperlipidemia. These findings suggest a neuroprotective effect and nutraceutical potential of Tucumã. Practical applicationsIn the present work, we demonstrated that induced hyperlipidemia in rats caused memory loss and redox unbalance, both factors prevented by the administration of Tucumã (Astrocaryum aculeatum) extract. Two aims were fulfilled with these results.The first was to show that hyperlipidemia affected brain function through oxidative damage and concerned basic research. The second was to offer a therapy that prevented this harm and could be applied in the clinic. Tucumã has ethnopharmacological importance through the consumption of fruits or the administration of extracts and oils by a population that was shown to enjoy improved health and longevity.Here, we show evidence that Tucumã contributes to the maintenance of brain health by preventing memory loss and oxidative damage, a nutraceutical supplement that may aid the prevention of vascular, inflammatory, and brain diseases.

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Astrocaryum aculeatum fruit improves inflammation and redox balance in phytohemagglutinin-stimulated macrophages

Cited by 24 publications

References 32 publications

Efeito in vitro do extrato de Tucumã (astrocaryum aculeatum) em células mononucleares de sangue periférico

Efeito in vitro do extrato de Tucumã (astrocaryum aculeatum) em células mononucleares de sangue periférico

Green and Sustainable Valorization of Bioactive Phenolic Compounds from Pinus By-Products

Tucumã ( Astrocaryum aculeatum ) prevents memory loss and oxidative imbalance in the brain of rats with hyperlipidemia

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