Astrocyte-Neuronal Communication and Its Role in Stroke

Yao, Zi-Meng; Sun, Xiao‐Rong; Huang, Jie; Chen, Lei; Dong, Shuying

doi:10.1007/s11064-023-03966-0

Cited by 6 publications

(1 citation statement)

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“…Moreover, astrocytes participate in maintaining pathways of amino acid metabolism, fatty acid metabolism, ion and water homeostasis, defense against oxidative stress, and anti-inflammation ( Sofroniew, 2020 ). Changes in these astrocytic pathways also influence the activity of neurons and may lead to neurological disorders ( Dzyubenko and Hermann, 2023 ; Patani et al, 2023 ; Yao et al, 2023 ).…”

Section: Astrocyte Morphology and Functionality In The Brainmentioning

confidence: 99%

Astrocyte metabolism and signaling pathways in the CNS

Zhang,

Qi,

Gao

et al. 2023

Front. Neurosci.

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Astrocytes comprise half of the cells in the central nervous system and play a critical role in maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated as the primary cause of neurological diseases, such as depression, Alzheimer’s disease, and epilepsy. Although the metabolic functionalities of astrocytes are well known, their relationship to neurological disorders is poorly understood. The ways in which astrocytes regulate the metabolism of glucose, amino acids, and lipids have all been implicated in neurological diseases. Metabolism in astrocytes has also exhibited a significant influence on neuron functionality and the brain’s neuro-network. In this review, we focused on metabolic processes present in astrocytes, most notably the glucose metabolic pathway, the fatty acid metabolic pathway, and the amino-acid metabolic pathway. For glucose metabolism, we focused on the glycolysis pathway, pentose-phosphate pathway, and oxidative phosphorylation pathway. In fatty acid metabolism, we followed fatty acid oxidation, ketone body metabolism, and sphingolipid metabolism. For amino acid metabolism, we summarized neurotransmitter metabolism and the serine and kynurenine metabolic pathways. This review will provide an overview of functional changes in astrocyte metabolism and provide an overall perspective of current treatment and therapy for neurological disorders.

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