ASXL3 gene mutations inhibit cell proliferation and promote cell apoptosis in mouse cardiomyocytes by upregulating lncRNA NONMMUT063967.2

Liu, Zequn; Jiang, Yuhang; Fu, Fang; Li, Ru; Han, Jin Hee; Yang, Xin; Deng, Qi; Li, Lu‐Shan; Lei, Tingying; Li, Dong-Zhi; Liao, Can

doi:10.1016/j.bbrep.2023.101505

Biochemistry and Biophysics Reports

2023

DOI: 10.1016/j.bbrep.2023.101505

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ASXL3 gene mutations inhibit cell proliferation and promote cell apoptosis in mouse cardiomyocytes by upregulating lncRNA NONMMUT063967.2

Zequn Liu

Yuhang Jiang

Fang Fu

et al.

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2024

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Cardiomyocyte proliferation and regeneration in congenital heart disease

Liang,

He,

Wang

2024

Pediatric Discovery

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Despite advances in prenatal screening and a notable decrease in mortality rates, congenital heart disease (CHD) remains the most prevalent congenital disorder in newborns globally. Current therapeutic surgical approaches face challenges due to the significant rise in complications and disabilities. Emerging cardiac regenerative therapies offer promising adjuncts for CHD treatment. One novel avenue involves investigating methods to stimulate cardiomyocyte proliferation. However, the mechanism of altered cardiomyocyte proliferation in CHD is not fully understood, and there are few feasible approaches to stimulate cardiomyocyte cell cycling for optimal healing in CHD patients. In this review, we explore recent progress in understanding genetic and epigenetic mechanisms underlying defective cardiomyocyte proliferation in CHD from development through birth. Targeting cell cycle pathways shows promise for enhancing cardiomyocyte cytokinesis, division, and regeneration to repair heart defects. Advancements in human disease modeling techniques, clustered regularly interspaced short palindromic repeats ‐based genome and epigenome editing, and next‐generation sequencing technologies will expedite the exploration of abnormal machinery governing cardiomyocyte differentiation, proliferation, and maturation across diverse genetic backgrounds of CHD. Ongoing studies on screening drugs that regulate cell cycling are poised to translate this nascent technology of enhancing cardiomyocyte proliferation into a new therapeutic paradigm for CHD surgical interventions.

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Cardiomyocyte proliferation and regeneration in congenital heart disease

Liang,

He,

Wang

2024

Pediatric Discovery

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ASXL3 gene mutations inhibit cell proliferation and promote cell apoptosis in mouse cardiomyocytes by upregulating lncRNA NONMMUT063967.2

Cited by 1 publication

References 28 publications

Cardiomyocyte proliferation and regeneration in congenital heart disease

Cardiomyocyte proliferation and regeneration in congenital heart disease

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