Asymmetric Mach–Zehnder Interferometer Using Biosensors

Abstract

We present a study of Aflatoxin M1 detection by photonic biosensors based on Si3N4 Asymmetric MachZehnder Interferometer (aMZI) functionalized with antibodies fragments (Fabʹ). We measured a best volumetric sensitivity of 10 4 rad/RIU, leading to a Limit of Detection below 5x10 -7 RIU. On sensors functionalized with Fabʹ, we performed specific and non-specific sensing measurements at various toxin concentrations. Reproducibility of the measurements and re-usability of the sensor were also investigated.