Asymmetric synthesis of pyrrolo[1,2-a]indoles via bifunctional tertiary amine catalyzed [3 + 2] annulation of 2-nitrovinylindoles with azlactones

Abstract

The chiral pyrrolo[1,2-a]indole represents a privileged stuctural motif in many natual products and pharmaceutical agents. Herein we developed an efficient [3+2] annulation of 2-nitrovinylindoles with azlactones via the cascade Michael...