Asymptomatic Bacteriuria Bacterial Profile and Antibiotic Susceptibility Pattern Among Pregnant Women Attending Antenatal Care (Anc) Clinic of Assosa General Hospital, Benishangul Gumuz Region, Western Ethiopia

Abstract

Background: ASB is a common problem in pregnant women and about 40% of women with untreated asymptomatic bacteriuria during pregnancy develop pyelonephritis, which might lead to low birth weight, preterm, premature rupture of membranes and preterm labour. Therefore, this study aimed to assess the prevalence of asymptomatic bacteriuria, antimicrobial susceptibility pattern of the isolates among pregnant women attending antenatal care clinic of Assosa General Hospital, western Ethiopia.Methods: A facility-based cross sectional study was conducted from January to February 2019. Well-mixed and uncentrifuged urine specimens obtained from the pregnant women was directly inoculated on cystine lactose electrolyte deficient agar (CLED) (Oxoid, Ltd, England) media by streak plate method. Bacterial isolates were identified as per the standard bacteriological procedure using colony characteristics, gram-staining, and series of biochemical tests. Antimicrobial susceptibility test was carried out by Kirby- Bauer disk diffusion technique on Muller-Hinton agar medium and the diameter of zone of inhibition was interpreted according toClinical Laboratory Standard Institute (CLSI) guidelinesResult: The overall prevalence of ASB among pregnant women in this study was 14.85%.E. coli was the most predominant isolate (50 %,) followed by K. pneumoniae (16.7%,), S. aureus (14.3%), coagulase negative staphylococci (CONS) (11.9%), and group B streptococci (GBS) (7.1%).Gram-negative bacteria were highly resistant for tetracycline (96.4%), ampicillin .Gram-positive bacteria were 100% sensitive for ceftazidime. Conclusion: Significant bacteriuria was observed in asymptomatic pregnant women. Therefore, routine laboratory diagnosis of ASB in pregnant women and providing appropriate treatment should be needed to reduce its complications.

Prevalence and antimicrobial susceptibility pattern of urinary tract infection among pregnant women attending Hargeisa Group Hospital, Hargeisa, Somaliland

“…In this study, S. aureus which constituted for 45% of the Gram positive bacteria showed 66.7–88.9% were sensitive to erythromycin, cefoxitin, ceftriaxone, nitrofurantoin, ciprofloxacin and gentamicin, this agree with study done in Hawassa, Ethiopia, Benishangul Gumuz Region, Western Ethiopia and Nairobi, Kenya 42 , 50 , 55 . In contrast to research done in Addis Ababa, Ethiopia, which erythromycin was highly resistant 60% 47 .…”

“…This could be due to the infrequent use of the drug in the study area. Comparable result was reported in Gonder Ethiopia 53 , in Lagos, Nigeria, and Benishangul Gumuz Region, Western Ethiopia 55 . Coagulase negative staphylococci, which were the predominant isolates from Gram-positives 55% and was found 63% to 81% sensitive to erythromycin, cefoxitin, ceftriaxone, nitrofurantoin gentamicin and ciprofloxacin.…”

Prevalence and Antimicrobial Susceptibility Pattern of Urinary Tract Infection among Pregnant Women Attending Hargeisa Group Hospital, Hargeisa, Somaliland

“…In this study, S. aureus which constituted for 45% of the gram positive bacteria showed 66.7%-88.9% were sensitive to erythromycin, cefoxitin, ceftriaxone, nitrofurantoin, cipro oxacin and gentamicin, this agree with study done in Hawassa, Ethiopia, Benishangul Gumuz Region, Western Ethiopia and Nairobi, Kenya 41,49,54 . In contrast to research done in Addis Ababa, Ethiopia, which erythromycin was highly resistant 60% 46 .…”