Asymptomatic colonization of Staphylococcus aureus with intermediate resistance to vancomycin harboring vanB resistance gene

Daghistani, Hala Al Al Ibrahim; Shquirat, Walid D.; Al-kharabsha, Muna; Al-latif, Saleh M Abd

doi:10.22159/ajpcr.2017.v10i5.17285

Cited by 4 publications

(3 citation statements)

References 35 publications

(42 reference statements)

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“…Besides, a recent study has shown that VISA growth rate is lower and that the cells harbor a thicker cell wall than those fully susceptible. 9 , 11 . Heterogeneous VISA (hVISA) show MICs in the susceptible range (≤ 2 μg/mL), but they contain a sub-population that expresses a resistant phenotype 12 , 13 .…”

Section: Introductionmentioning

confidence: 99%

Global prevalence and distribution of vancomycin resistant, vancomycin intermediate and heterogeneously vancomycin intermediate Staphylococcus aureus clinical isolates: a systematic review and meta-analysis

Shariati

Dadashi

Moghadam

et al. 2020

Sci Rep

197

126

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Vancomycin-resistant Staphylococcus aureus (VRSA), Vancomycin-intermediate S. aureus (VISA) and heterogeneous VISA (hVISA) are subject to vancomycin treatment failure. The aim of the present study was to determine their precise prevalence and investigate prevalence variability depending on different years and locations. Several international databases including Medline (PubMed), Embase and Web of Sciences were searched (data from 1997 to 2019) to identify studies that addressed the prevalence of VRSA, VISA and hVISA among human clinical isolates around the world. Subgroup analyses and meta-regression were conducted to indicate potential source of variation. Publication bias was assessed using Egger’s test. Statistical analyses were conducted using STATA software (version 14.0). Data analysis showed that VRSA, VISA and hVISA isolates were reported in 23, 50 and 82 studies, with an overall prevalence of 1.5% among 5855 S. aureus isolates, 1.7% among 22,277 strains and 4.6% among 47,721 strains, respectively. The overall prevalence of VRSA, VISA, and hVISA before 2010 was 1.2%, 1.2%, and 4%, respectively, while their prevalence after this year has reached 2.4%, 4.3%, and 5.3%. The results of this study showed that the frequency of VRSA, VISA and hVISA after 2010 represent a 2.0, 3.6 and 1.3-fold increase over prior years. In a subgroup analysis of different strain origins, the highest frequency of VRSA (3.6%) and hVISA (5.2%) was encountered in the USA while VISA (2.1%) was more prevalent in Asia. Meta-regression analysis showed significant increasing of VISA prevalence in recent years ( p value ≤ 0.05). Based on the results of case reports (which were not included in the calculations mentioned above), the numbers of VRSA, VISA and hVISA isolates were 12, 24 and 14, respectively, among different continents. Since the prevalence of VRSA, VISA and hVISA has been increasing in recent years (especially in the Asian and American continents), rigorous monitoring of vancomycin treatment, it’s the therapeutic response and the definition of appropriate control guidelines depending on geographical regions is highly recommended and essential to prevent the further spread of vancomycin-resistant S. aureus .

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Section: Introductionmentioning

confidence: 99%

Global prevalence and distribution of vancomycin resistant, vancomycin intermediate and heterogeneously vancomycin intermediate Staphylococcus aureus clinical isolates: a systematic review and meta-analysis

Shariati

Dadashi

Moghadam

et al. 2020

Sci Rep

197

126

View full text Add to dashboard Cite

show abstract

“…The results of the current study were an approach to the researcher's findings [13]; in Diyala in Iraq in a study including 100 isolation from E. coli bacteria to detect their susceptibility to antibiotic resistance, the results show that 22% of isolates were of multiple resistance while the resistance to ampicillin was 100%; the researcher is likely to cause resistance to the use of antibiotics for long-term treatment [14]. The reason for tetracycline resistance in E. coli bacteria is the presence of flow pump efflux pumps of major facilitator super family (MFS) flow pumps that expel anti-tetracycline to the outside and do not expel minocycline, the protein that is encoded by the tetB gene only for it.…”

Section: Discussionmentioning

confidence: 99%

Detection and Analysis of Resistance Genes in Escherichia coli Bacteria Isolated from Children in Baghdad

Zeadan

Saleem

Abbas

2022

Advanced Gut & Microbiome Research

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Urinary tract infections are common diseases and Escherichia coli is the most common cause of this disease, especially in infants and children. The 200 samples were collected for the period from July to December 2020 from the Central Children’s Hospital in Baghdad from infants and children and cultured on MacConkey and blood agar for primary isolation of E. coli bacteria. The VITEK 2 system was used for biochemical tests and final identification. Antibiotic susceptibility for 16 antibiotics was determined using the VITEK 2 system, as well as the ability for biofilm formation using the tissue culture plate method, while DNA was isolated for molecular antibiotic resistance genes tetA, tetB, CITM, sul1, sul2, and sul3 using the standard polymerase chain reaction. Results showed that 40/62 isolates (64%) belonged to E. coli bacteria (32 females and 8 males), and isolates were of varying resistance to antibiotics, with the highest resistance to ampicillin and sulfamethoxazole and the lowest resistance to tigecycline and most MDR. The percentage of biofilm formation ability was 62.5%. The ratio of resistance genes CITM, tetA, tetB, sul1, and sul2 for E. coli bacteria was 5%, 45%, 12.5%, 35%, and 40%, respectively, while the sul3 gene did not appear in isolation from any clinical local isolation. So, E. coli isolates isolated from children showed a high extent of antibiotic resistance as the genetic sequencing of resistance genes showed that there were many mutations with a type of transmission or silence or transition. In conclusion, E. coli isolated from children was highly resistant to antibiotics and had the ability to form biofilms as well as the presence of a resistance gene that could be transmitted among bacteria and spread antibiotic resistance.

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“…Previous studies [ 7 , 19 ] proposed that brain infusion or oral administration of propionic acid (PPA) to rat pups could induce many of the biochemical characteristics observed in individuals with autism. Moreover, histopathological changes, such as neuronal loss, hyaline bodies, and astrogliosis, together with several behavioral traits such as hyperactivity, impaired social interaction, reduced exploratory activity, and increased repetitive behaviors, have been recorded [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Novavit in ameliorating the neurotoxicity of propionic acid

Bukhari

Alfawaz

Al-Dbass

et al. 2020

Translational Neuroscience

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AbstractOxidative stress, abnormal fatty acid metabolism, and impaired gut microbiota play a serious role in the pathology of autism. The use of dietary supplements to improve the core symptoms of autism is a common therapeutic strategy. The present study analyzed the effects of oral supplementation with Novavit, a multi-ingredient supplement, on ameliorating oxidative stress and impaired lipid metabolism in a propionic acid (PPA)-induced rodent model of autism. Male western albino rats were divided into three groups. The first group is the control, the second group was given an oral neurotoxic dose of PPA (250 mg/kg body weight/day) for 3 days and then received buffered saline until the end of the experiment. The third group received Novavit (70 mg/kg body weight/day for 30 days after the 3-day PPA treatment). Markers of oxidative stress and impaired fatty acid metabolism were measured in brain homogenates obtained from each group. Novavit modulation of the gut microbiota was also evaluated. While PPA induced significant increases in lipid peroxides and 5-lipoxygenase, together with significantly decreased glutathione, and cyclooxygenase 2, oral supplementation with Novavit ameliorated PPA-induced oxidative stress and impaired fatty acid metabolism. Our results showed that the presence of multivitamins, coenzyme Q10, minerals, and colostrum, the major components of Novavit, protects against PPA-induced neurotoxicity.

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Asymptomatic colonization of Staphylococcus aureus with intermediate resistance to vancomycin harboring vanB resistance gene

Cited by 4 publications

References 35 publications

Global prevalence and distribution of vancomycin resistant, vancomycin intermediate and heterogeneously vancomycin intermediate Staphylococcus aureus clinical isolates: a systematic review and meta-analysis

Global prevalence and distribution of vancomycin resistant, vancomycin intermediate and heterogeneously vancomycin intermediate Staphylococcus aureus clinical isolates: a systematic review and meta-analysis

Detection and Analysis of Resistance Genes in Escherichia coli Bacteria Isolated from Children in Baghdad

Efficacy of Novavit in ameliorating the neurotoxicity of propionic acid

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