Asymptomatic elevation of creatine kinase in patients with hyponatremia

Khow, Kareeann Sok Fun; Lau, Su Yin; Li, Jordan; Yong, Tuck Yean

doi:10.3109/0886022x.2014.900600

Cited by 9 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No causal association has been established between desmopressin acetate‐induced hyponatremia and muscle injury in animal studies 19 . In a clinical study, asymptomatic hyperCKemia was associated with hyponatremia caused by diuretics and polydipsia, which may have been complicated by AKI 20 . Compared to ultra‐athletes with normonatremia, exercise‐associated hyponatremia is prone to develop into exercise‐associated RM 21 .…”

Section: Discussionmentioning

confidence: 99%

“… 19 In a clinical study, asymptomatic hyperCKemia was associated with hyponatremia caused by diuretics and polydipsia, which may have been complicated by AKI. 20 Compared to ultra‐athletes with normonatremia, exercise‐associated hyponatremia is prone to develop into exercise‐associated RM. 21 Severe hyponatremia was observed in patient 4, and we considered that hyponatremia might promote the development of hyperCKemia.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Characteristics and treatments of patients with significantly elevated creatine kinase levels induced by seizures: Case report and literature review

Wang,

Yang,

et al. 2023

Clinical Case Reports

View full text Add to dashboard Cite

Key Clinical MessageMotor signs accompanying seizures have been considered to result in overexertion of muscles and have the ability to cause elevated levels of serum creatine kinase (CK). There were no previous studies on the treatment of seizure‐induced elevated CK. We summarized the characteristics and treatments of six patients with significant elevation of CK after seizure onset. There were four males and two females, the age range was 16–68 years. The CK levels were greater than 5000 U/L in five of the six patients and the highest CK level was 39,300 U/L. All patients exhibited an estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73m2. No patient developed renal failure or required continuous renal replacement therapy. We determined that serial assessment of CK, myoglobin, eGFR, and electrolytes should be performed in patients following seizures. Furthermore, fluid resuscitation, urine alkalization, and diuretic agents should be administrated when CK are significantly elevated after seizure onset. Serial assessment of CK levels after seizures should be performed, especially when the patient experiences electrolyte disorders. Fluid resuscitation, urine alkalization, and diuretic agents also should be administrated to patients when they exhibit a significantly elevated CK or myoglobin after seizures.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Characteristics and treatments of patients with significantly elevated creatine kinase levels induced by seizures: Case report and literature review

Wang,

Yang,

et al. 2023

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

“…Comparably, hyponatremia overcorrection has been known to cause rhabdomyolysis as indicated by elevated CPK and/or renal failure [ 12 ]. This degree of elevation can vary generally from the hundreds to the low thousands.…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis in the Setting of Severe Hyponatremia: A Case Report

Mathew¹,

Chilakala²,

Elfert³

2023

Cureus

View full text Add to dashboard Cite

Electrolyte imbalances are common problems among hospitalized patients, and they can have severe consequences. Although rare, severe hyponatremia or low sodium (Na) levels have been associated with the occurrence of rhabdomyolysis. This is a case of a 45-year-old man who presented with confusion and lethargy and was found to have severe hyponatremia with an elevated creatine phosphokinase (CPK) level of 45,440 IU/L. With the administration of normal saline, the Na levels and CPK improved. He was discharged from the hospital in stable clinical condition. This case demonstrates the need for providers to monitor rhabdomyolysis markers in severe hyponatremia, as there is an observed association between the two and the sequelae can be severe.

show abstract

“…Hypokalemia is reported to cause myocyte destruction and the leakage of troponin, CK-MB, and LDH from the damaged membranes into the circulation. 23 Hypokalemia-induced myopathy and massive CK elevation as the first presentation of Conn’s syndrome may occur due to hypertension. 24 Zhang et al 9 in 2004 reported that the administration of glucose-insulin-K combination attenuated the accumulation of LDH and CK in rabbits subjected to myocardial injuries.…”

Section: Discussionmentioning

confidence: 99%

Effects of Acute Potassium Chloride Administration on Ventricular Dysrhythmias after Myocardial Infarction in a Rat Model of Ischemia/Reperfusion

Madadi¹,

Aghajani²,

Dabbagh³

et al. 2022

JTHC

View full text Add to dashboard Cite

Background: Acute myocardial infarction is an important cause of morbidity. This study aimed to investigate the effects of the administration of potassium chloride (KCl) on reperfusion-induced injuries in a rat model of myocardial ischemia/reperfusion. Methods: Thirty-six male Wistar rats, weighing 200 to 250 g, were randomly assigned to 3 experimental groups: control, K1 (10 µg/kg of KCl), and K2 (20 µg/kg of KCl). Twenty minutes before ischemia, a single dose of 10 and 20 µg/kg of KCl was intraperitoneally administered in the K1 and K2 groups, respectively. The coronary artery was occluded for 30 minutes (ischemia); thereafter, it was opened for 60 minutes (reperfusion) to measure hemodynamic parameters and ventricular arrhythmias. Blood sampling was performed after the reperfusion period to determine the serum levels of lactate dehydrogenase, troponin I, creatine kinase (CK)-MB, malondialdehyde, and pro-oxidant-antioxidant balance. Results: Serological parameters significantly decreased in the potassium groups compared with the control group. In particular, the decline was more pronounced for the serum levels of lactate dehydrogenase (1180.25±69.48 vs 1556.67±77.02 U/L; P=0.011), troponin I (21.98±0.61 vs 28.76±1.65 ng/mL; P=0.020), and pro-oxidant-antioxidant balance (15.51±0.72 vs 20.63±1.42 HK; P=0.041) in the K2 group compared with the K1 group. Moreover, the administration of 20 µg/kg of KCl significantly decreased the incidence of ventricular tachycardias and fibrillations compared with the control group (P=0.002). Additionally, no considerable differences were observed between the control group and the groups with 10 µg/kg and 20 µg/kg of KCl regarding the number of ventricular ectopic beats. Conclusion: The administration of KCl before ischemia could reduce ventricular arrhythmias and reperfusion-induced injuries by reducing oxidative stress.

show abstract

Asymptomatic elevation of creatine kinase in patients with hyponatremia

Cited by 9 publications

References 28 publications

Characteristics and treatments of patients with significantly elevated creatine kinase levels induced by seizures: Case report and literature review

Characteristics and treatments of patients with significantly elevated creatine kinase levels induced by seizures: Case report and literature review

Rhabdomyolysis in the Setting of Severe Hyponatremia: A Case Report

Effects of Acute Potassium Chloride Administration on Ventricular Dysrhythmias after Myocardial Infarction in a Rat Model of Ischemia/Reperfusion

Contact Info

Product

Resources

About