Asymptomatic malaria parasitemia does not induce additional oxidative stress in pregnant women of South East Nigeria

Nwagha, UI; Okeke, TC; Nwagha, Theresa Ukamaka; Ejezie, FE; Ogbodo, Sylvester Ogbonna; Dim, Cyril Chukwudi; Anyaehie, Ugochukwu Bond

doi:10.1016/s1995-7645(11)60076-x

Cited by 11 publications

(14 citation statements)

References 22 publications

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“…Intestinal epithelial cells are important sensors of microbial infection. Intestinally derived transformed cell lines produce a variety of pro-inflammatory mediators in response to intracellular infection with bacteria including interleukins 1 and 8 cyclooxygenase-2 and inducible nitric oxide synthase [16][17][18][19][20][21] . Several of these mediators cause activation of neutrophils and macrophages, providing a mechanism by which intestinal epithelial cells import these cells to the site of pathogen invasion.…”

Section: Disscussionmentioning

confidence: 99%

“…As a result, lipid peroxidation causes changes in membrane permeability and selectivity and ultimately leads to alterations in cell volume homeostasis and cellular metabolism. Moreover, hydroperoxides and aldehydes are directly toxic to cells and organelles, have neutrophil chemotactic properties and may regulate cytokine production [16][17][18][19][20][21][22] .…”

Section: Disscussionmentioning

confidence: 99%

“…Although NO is a highly lipid-soluble molecule with a considerably long high life, capable of diffusing through several cells from its site of synthesis, there is still much debate as to whether NO production is actually harmful to inflamed tissue or not. It is also unclear whether the NO producing enzyme nitric oxide synthase, is expressed by inflammatory cells [16][17][18][19][20][21] . We have found that NO an index of nitrosative stress, is significantly increased in patients with acute intestinal amebiasis comparing with the control subjects (P<0.001).…”

Section: Disscussionmentioning

confidence: 99%

See 2 more Smart Citations

Increased serum nitric oxide and malondialdehyde levels in patients with acute intestinal amebiasis

Namiduru¹,

Tarakçıoğlu²,

Namıduru³

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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Section: Disscussionmentioning

confidence: 99%

Section: Disscussionmentioning

confidence: 99%

Section: Disscussionmentioning

confidence: 99%

See 1 more Smart Citation

Increased serum nitric oxide and malondialdehyde levels in patients with acute intestinal amebiasis

Namiduru¹,

Tarakçıoğlu²,

Namıduru³

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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show abstract

“…A number of studies have reported asymptomatic malaria in Nigeria (Achidi et al, 1995; Anorlu et al, 2001; Jeremiah and Uko, 2007; Kotila et al, 2007; Nwagha et al, 2011; Nwagha et al, 2009; Nwaneri et al, 2013; Ojurongbe et al, 2011). However, these studies are mostly descriptive and extensive analytical studies are lacking.…”

Section: Introductionmentioning

confidence: 99%

High prevalence of Plasmodium malariae and Plasmodium ovale in co-infections with Plasmodium falciparum in asymptomatic malaria parasite carriers in Southwest Nigeria

Abdulraheem

Ernest

Ugwuanyi

et al. 2021

Preprint

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Asymptomatic malaria parasite carriers do not seek anti-malarial treatment and may constitute a silent infectious reservoir. In order to assess the level of asymptomatic and symptomatic carriage amongst adolescents in a highly endemic area, and to identify the risk factors associated with such carriage, we conducted a cross sectional survey of 1032 adolescents (ages 10-19) from eight schools located in Ibadan, Southwest Nigeria in 2016. Blood films and blood spot filter paper samples were prepared for microscopy and DNA analysis. The prevalence of asymptomatic malaria was determined using microscopy, rapid diagnostic tests and PCR for 658 randomly selected samples. Of these, we found that 80% of asymptomatic schoolchildren were positive for malaria parasites by PCR, compared to 47% and 9% determined by RDT and microscopy, respectively. Malaria parasite species typing was performed using PCR targeting the mitochondrial CoxIII gene, and revealed high rates of carriage of Plasmodium malariae (53%) and Plasmodium ovale (24%). Most asymptomatic infections were co-infections of two or more species (62%), with P. falciparum + P. malariae the most common (35%), followed by P. falciparum + P. malariae + P. ovale (21%) and P. falciparum + P. ovale (6%). Single infections of P. falciparum, P. malariae and P. ovale accounted for 24%, 10% and 4% of all asymptomatic infections respectively. To compare the species composition of asymptomatic and symptomatic infections, further sample collection was carried out in 2017 at one of the previously sampled schools, and at a nearby hospital. Whilst the species composition of the asymptomatic infections was similar to that observed in 2016, the symptomatic infections were markedly different, with single infections of P. falciparum observed in 91% of patients, P. falciparum + P. malariae in 5% and P. falciparum + P. ovale in 4%.

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“…[5] The resultant effect is the generation of enormous free radicals and initiation of oxidative stress which have been implicated in uncountable perinatal and maternal illnesses. [6][7][8] Antioxidants include organic molecules (minerals and vitamins), enzymes, and dietary chemicals (phytochemicals) used in preventing the effects of oxidative stress. Defence against oxidative stress is largely dependent upon an orchestrated synergism between some of these endogenous and exogenous antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Parity may determine levels of some antioxidant minerals in pregnancy: An experience from rural South-Eastern Nigeria

Ogbodo¹,

Okaka²,

Nwagha³

2014

J Basic Clin Reprod Sci

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Background: Maternal micronutrient and antioxidant status is critical to fetal growth and survival. Poor socioeconomic conditions in the rural areas portend undernutrition with inevitable micronutrients deficiencies. Presently, there are conflicting reports on the serum levels of some mineral antioxidants during pregnancy. Aim: To determine the serum concentrations of some antioxidant minerals-copper and manganese, in rural pregnant women of different parities. Subjects and Methods: This is a cross-sectional study, involving 195 rural pregnant women, in different trimesters and parities. They were recruited from antenatal clinics of some rural health centres in southeastern Nigeria. The controls were 50 age-matched, nonpregnant, nulliparous, and apparently healthy women, who were not menstruating at the time of sample collection. Results: The results showed that copper was nonsignificantly lower (P = 0.14), while manganese was significantly higher (P < 0.001) in pregnant women than nonpregnant women. Over gestation, there was no significant changes (P = 0.081; F = 2.268; r 2 = 0.028) in copper concentrations as pregnancy progressed while manganese increased significantly (P < 0.001; F = 18.370; r 2 = 0.195), and remained relatively so, throughout gestation. However, both antioxidants increased progressively and significantly as parity increased (P < 0.001). Conclusion: Parity influences the levels of these antioxidant minerals in pregnancy and therefore should play significant role in the determination of the actual dose of supplements, if need be, of these antioxidants during pregnancy. Indeed assessment and supplementation of copper and manganese during pregnancy should be individualized to avoid deleterious fetomaternal consequences.

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Asymptomatic malaria parasitemia does not induce additional oxidative stress in pregnant women of South East Nigeria

Abstract: Asymptomatic malaria parasitemia does not induce additional oxidative stress on pregnant women in Nigeria. The enormity of acute and complicated attack should be further investigated.

Cited by 11 publications

References 22 publications

Increased serum nitric oxide and malondialdehyde levels in patients with acute intestinal amebiasis

Increased serum nitric oxide and malondialdehyde levels in patients with acute intestinal amebiasis

High prevalence of Plasmodium malariae and Plasmodium ovale in co-infections with Plasmodium falciparum in asymptomatic malaria parasite carriers in Southwest Nigeria

Parity may determine levels of some antioxidant minerals in pregnancy: An experience from rural South-Eastern Nigeria

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