Asymptomatic Sensorineural Hearing Loss in Patients With Systemic Lupus Erythematosus

Roverano, Susana; Cassano, Gustavo; Paira, Sergio; Chiavarini, Jorge; Graf, César; Rico, Luisa; Heredia, Cristina Díaz de

doi:10.1097/01.rhu.0000242777.71604.69

Cited by 60 publications

(67 citation statements)

References 37 publications

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“…Ioannis Kastanioudakis, Nausica Ziavra et al in their clinical study concluded that 1/4th of SLE patients in their study had SNHL in mid and high frequencies and this was a lower percentage when compared to other authors. (28) Roverano S, Cassano G, et al in a clinical study to evaluate SNHL in SLE patients found that 70% of the patients had HL and 66% had sensory neural loss at higher frequency bilateral and symmetrical. No correlation was found between SLE activity and hearing loss.…”

Section: Methodsmentioning

confidence: 98%

Audiological Evaluation in Auto - Immune Skin Diseases : A Clinical Study of 124 Patients

A¹,

M²,

S³

et al. 2015

jemds

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Section: Methodsmentioning

confidence: 98%

Audiological Evaluation in Auto - Immune Skin Diseases : A Clinical Study of 124 Patients

A¹,

M²,

S³

et al. 2015

jemds

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“…When the oculomotor, trochlear and abducent nerves are involved, myasthenia gravis should be ruled out. Different mechanisms have been proposed such as vasculitis secondary to SLE, microinfarction of the capillaries or arterioles in the temporal bone, and thrombosis in the otologic region 56 . Autoimmune sensory neural hearing loss in SLE is associated with a poor prognosis.…”

Section: Cranial Neuropathiesmentioning

confidence: 99%

Neuropsychiatric Lupus in clinical practice

Alessi

Dutra

Neto

et al. 2016

Arq. Neuro-Psiquiatr.

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs, characterized by the production of autoantibodies and the development of tissue injury. The etiology of SLE is partially known, involving multiple genetic and environmental factors. As many as 50% of patients with SLE have neurological involvement during the course of their disease. Neurological manifestations are associated with impaired quality of life, and high morbidity and mortality rates. Nineteen neuropsychiatric syndromes have been identified associated with SLE, and can be divided into central and peripheral manifestations. This article reviews major neuropsychiatric manifestations in patients with SLE and discusses their clinical features, radiological findings and treatment options.

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“…Hal ini dibuktikan oleh Roverano dkk. 6 di Santa Fe, Argentina yang melakukan penelitian pada 30 wanita LES yang pada saat itu tidak mengeluh gangguan dengar atau riwayat penyakit telinga pada keluarga, ternyata pada pemeriksaan audiometri 20 pasien menunjukkan gangguan dengar sensorineural pada frekuensi tinggi, bilateral, dan simetris.…”

Section: Pendahuluanunclassified

Pengaruh Prednison terhadap Perbaikan Pendengaran Penderita Lupus Eritematosus

Wijana¹,

Mutiara²,

Agustian³

2016

mkb

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AbstrakLupus eritematosus sistemik (LES) merupakan penyakit kronik mengenai multisistem, merupakan gangguan autoimun yang ditandai oleh produksi autoantibodi dan deposisi kompleks imun di jaringan. Manifestasi klinis dapat meliputi berbagai organ termasuk telinga. Pada telinga dapat menimbulkan gangguan dengar, tinitus, dan vertigo. Gangguan dengar terjadi bilateral pada frekuensi tinggi. Prednison merupakan kortikosteroid oral yang memiliki efek glukokortikoid yang bersifat anti-inflamasi dan imunosupresif. Penelitian ini bertujuan mengetahui pengaruh prednison terhadap perbaikan pendengaran penderita LES. Penelitian dilakukan periode Maret-Mei 2013 di Poliklinik Gangguan Dengar dan Bicara, Telinga Hidung Tenggorok Bedah Kepala dan Leher Rumah Sakit Dr. Hasan Sadikin Bandung menggunakan metode quasi-experimental dengan rancangan one group pretestposttest design dan hasilnya dihitung secara statistik menggunakan uji Rank Spearman. Pada 28 subjek pasien LES dilakukan anamnesis, pemeriksaan fisis, laboratorium, audiometri nada murni, timpanometri, dan distortion production otoacoustic emissions. Subjek diberi prednison 1 mg/kgBB/hari (dosis maksimal 60 mg/hari) selama 4 minggu, kemudian dilakukan evaluasi ulang. Sebelum terapi, 26 subjek mengalami gangguan dengar sedang pada frekuensi tinggi, simetris. Sesudah terapi, 24 subjek ambang dengar menjadi normal dan 4 subjek tetap mengalami gangguan dengar (Rs=0,734; p<0,01 Prednisone Effect to on Hearing Status of Systemic Lupus Erythematosus Patients AbstractSystemic lupus erythematosus (SLE) is a chronic, multi-system, autoimmune disorder characterized by the production of autoantibodies and immune complexes deposition in tissue. Clinical manifestations may include skin, mucosa, joints, blood, heart, lungs, kidneys, central nervous system (CNS), immune system, and ears. SLE Iin the ears can caused sensorineural hearing loss, tinnitus, and vertigo. This hearing disorder is commonly bilateral and has high frequencies. Prednisone is an oral corticosteroid with glucocorticoid and mineralocorticoid effects. Glucocorticoids have anti-inflammatory and immunosuppressive effects. The aim of this study was to evaluate the effect of prednisone in improving the degree of hearing loss in patients with SLE. This study was conducted in from March-May 2013, at tThe Hearing and Speech Disorder Clinic of Ear Nose Throat-Head and Neck Surgery, Dr. Hasan Sadikin Hospital Bandung, using quasi-experimental method with pre-post design in which the results were statistically calculated using Rank Spearman test. This study involved 28 subjects who had been diagnosed for SLE. Anamnesis, physical examination, and laboratory test were performed, followed by pure tone audiometry, tympanometry, and distortion product optoacoustic emissions (DPOAE). Subjects were given prednisone 1 mg/kgBW/day with a maximum dose of 6o mg/day. Re-evaluation was performed after 4 weeksof treatment. Before treatment, 26 subjects had mild hearing loss and 2 subjects had symmetric moderate hearing loss at high freque...

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Asymptomatic Sensorineural Hearing Loss in Patients With Systemic Lupus Erythematosus

Abstract: If it can be established how often this ASNHL progresses to a clinical problem, it can be important that, as part of initial studies, patients with SLE undergo audiometric tests.

Cited by 60 publications

References 37 publications

Audiological Evaluation in Auto - Immune Skin Diseases : A Clinical Study of 124 Patients

Audiological Evaluation in Auto - Immune Skin Diseases : A Clinical Study of 124 Patients

Neuropsychiatric Lupus in clinical practice

Pengaruh Prednison terhadap Perbaikan Pendengaran Penderita Lupus Eritematosus

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