At least seven days delayed stenting using minimalist immediate mechanical intervention (MIMI) in ST-segment elevation myocardial infarction: the SUPER-MIMI study

Mester, Petru; Bouvaist, Hélène; Delarche, Nicolas; Bouisset, Frédéric; Abdellaoui, Mohamed; Petiteau, Pierre-Yves; Dubreuil, Olivier; Boueri, Ziad; Chettibi, Mohamed; Madiot, H.; Belle, Loïc

doi:10.4244/eij-d-16-00667

Cited by 10 publications

(13 citation statements)

References 18 publications

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“…The study design of the SUPER-MIMI study has previously been described (8). Briefly, SUPER-MIMI was a prospective, observational trial conducted between January 2014 and April 2015 in 14 French centres.…”

Section: Super-mimi Study Designmentioning

confidence: 99%

“…Although this strategy does not improve outcomes in non-selected patients with ST-segment elevation myocardial infarction (STEMI), it may be effective in specific subgroups (6). It also allows for a better assessment of the underlying culprit lesion, particularly in case of high thrombus burden (7,8).…”

Section: Introductionmentioning

confidence: 99%

“…The SUPER-MIMI strategy-which consists of restoring TIMI 3 flow with thin tools and postponing a second angiogram for ≥7 days-has been proven to be safe (8,9) and is commonly used in culprit lesions with a high thrombus burden. With a longer delay between the two procedures, this strategy allows for a better thrombus dissolution over time on antiplatelet therapy and may provide a safer condition in which to implant the stent.…”

Section: Introductionmentioning

confidence: 99%

“…With a longer delay between the two procedures, this strategy allows for a better thrombus dissolution over time on antiplatelet therapy and may provide a safer condition in which to implant the stent. In the SUPER-MIMI study (8), 1.3% of patients had reinfarction of the infarct-related artery between the first and the second procedures, both of whom were not treated with glycoprotein IIb/IIIa inhibitors. In the SUPER-MIMI study, 36.8% of STEMI patients were managed without stent implantation or balloon angioplasty (8).…”

Section: Introductionmentioning

confidence: 99%

“…In the SUPER-MIMI study (8), 1.3% of patients had reinfarction of the infarct-related artery between the first and the second procedures, both of whom were not treated with glycoprotein IIb/IIIa inhibitors. In the SUPER-MIMI study, 36.8% of STEMI patients were managed without stent implantation or balloon angioplasty (8). These patients had complete thrombus dissolution without any significant residual stenosis (<50%) after the second angiogram.…”

Section: Introductionmentioning

confidence: 99%

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Safety of conservative management for non-stenotic culprit lesions in STEMI patients treated with a two-step reperfusion strategy: a SUPER-MIMI sub-study

Bonnet

Marlière

Mathieu

et al. 2022

Cardiovasc Diagn Ther

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Background: In the observational SUPER-MIMI study, a minimalist immediate mechanical intervention (MIMI) technique-which involves restoring blood flow in the acute phase and postponing stenting-was shown to be safe and effective among patients with a high thrombotic burden after ST-segment elevation myocardial infarction (STEMI). We aim to assess whether a non-stenting strategy after a SUPER-MIMI strategy was safe at 4-year follow-up in patients enrolled in the SUPER-MIMI study who were not stented.Methods: This prospective cohort study assessed the long-term outcomes of a subgroup of patients included in the SUPER-MIMI study.Results: Among the 155 patients enrolled in the SUPER-MIMI study, 57 patients (36.8%) benefited from a conservative management (without stenting or balloon angioplasty) and were included in the current substudy. The mean duration of follow-up was 4.1±1.0 years. Four patients (7.0%) presented definite culprit lesion re-thrombosis, all of which occurred in the right coronary artery. The re-thrombosis rate appeared to be higher among patients with larger vessels: 2.9%, 8.3%, and 28.6% in arteries with diameters of 3-<4, 4-<5, and ≥5 mm, respectively. The overall rate of target lesion revascularization was 10.5%. There was one cardiac death and three rehospitalizations for heart failure. Overall, 82.5% of patients remained event free at a mean of 4.1±1.0 years. Conclusions:Conservative management of non-stenotic culprit lesions after a SUPER-MIMI strategy was associated with a high rate of re-thrombosis, particularly in patients with large coronary arteries.

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Section: Super-mimi Study Designmentioning

confidence: 99%