ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane

Oligonucleotide microarray analysis of differential transporter regulation in the regenerating rat liver

“…In the perfused liver an approximately two‐fold increase of alanine uptake and a three‐fold increase of glycine uptake were determined 12 h after PH compared with control livers (Table 4). This is in line with previous data demonstrating increased hepatic influx of amino acids such as alanine and glycine during liver regeneration (36, 37). Inhibition of alanine influx decreased hepatocyte proliferation (38).…”

Molecular aspects of medicine: from experimental to clinical hepatology

“…Cell swelling induced by cellular uptake of ions and amino acids is important for completion of the cell cycle (Paris and Pouyssegur, 1986;Panet and Atlan, 2000;Amsler et al, 1985;Panet et al, 1986Panet et al, , 1994Berman et al, 1995;Bussolati et al, 1996;Bildin et al, 2000;Kim et al, 2001a,b,c;Shen et al, 2001a,b) and is accordingly involved in liver regeneration (Freeman et al, 1999(Freeman et al, , 2002. In addition, immunological performances of macrophages and the cellular susceptibility to chemical and thermal damage critically depend on the cellular hydration state and the availability of compatible organic osmolytes such as betaine, taurine and myoinositol (Shapiro and Dinarello, 1995;Wettstein and H€ aussinger, 1997;Saha et al, 1992;Zhang et al, 1995aZhang et al, ,b, 1996aWarskulat et al, 1997a;Denkert et al, 1998;Kurz et al, 1998;Wettstein et al, 1998;Schliess et al, 1999;Lordnejad et al, 2001;Reinehr et al, 2002a,b;Pingle et al, 2003, for reviews see Schliess and H€ aussinger, 2002;H€ aussinger et al, 1997a,b;Lang et al, 2000b).…”

Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues

“…ATA2 is ubiquitously expressed in every tissue (8), and ATA3 is expressed almost exclusively in the liver (9). Among these genes, ATA2 activity is induced in regenerating livers (10,11). In carcinomas, the estrogen-dependent activation of system A is observed in breast cancers (12).…”